Neural correlates of retrieval of declarative memories modulated by the reconsolidation process

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dc.contributor.advisorRodríguez B., Eugenio
dc.contributor.authorCampos Arteaga, Germán Adolfo
dc.contributor.otherPontificia Universidad Católica de Chile. Escuela de Medicina
dc.date.accessioned2019-06-21T16:21:37Z
dc.date.available2019-06-21T16:21:37Z
dc.date.issued2019
dc.descriptionTesis (Ph.D. in Neuroscience)--Pontificia Universidad Católica de Chile, 2019
dc.description.abstractConsolidated memories can return to a labile state if they are reactivated by unpredictable reminders. To persist, active memories must be re-stabilized through a process known as reconsolidation. Although there is consistent behavioral evidence about this process in humans, the retrieval process of reconsolidated memories remains poorly understood. In this context, one fundamental question is whether the same or different neurophysiological mechanisms are involved in retrieval of consolidated and reconsolidated memories. Because it has been demonstrated that the exposure to the reconsolidation process may restructure and strengthen memories, we hypothesized distinct neurophysiological patterns reflecting enhanced recollective processes during retrieval of reconsolidated memories. Moreover, we hypothesized that the administration of an amnesic agent during reconsolidation, such as a new learning, can reverse these neurophysiological changes. To test it, consolidated and reconsolidated declarative memories (and memories whose reconsolidation process was interfered) (i.e., picture-word pairs) were evaluated in humans in an old/new associative recall task while the brain activity and the pupillary response were recorded using electroencephalography and eyetracking. Our results showed that retrieval of reconsolidated memories elicits specific patterns of brain activation, characterized by an earlier peak latency of the parietal ERP old/new effect compared to memories that were consolidated or whose reconsolidation process was disrupted by a new learning. Moreover, our results demonstrated that only retrieval of reconsolidated memories is associated to a late reversed mid-frontal effect. Complementarily, reactivated memories showed an earlier peak latency of the pupil old/new effect compared to nonreactivated memories. Based on these results, we argue that partially distinct brain mechanisms – presumably associated to enhanced recollective processes - support retrieval of reconsolidated declarative memories.
dc.format.extent102 páginas
dc.identifier.doi10.7764/tesisUC/MED/23002
dc.identifier.urihttps://doi.org/10.7764/tesisUC/MED/23002
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/23002
dc.information.autorucEscuela de Medicina ; Rodríguez B., Eugenio ; S/I ; 65567
dc.information.autorucEscuela de Medicina ; Campos Arteaga, Germán Adolfo ; S/I ; 119815
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherMemoria - Fisiologíaes_ES
dc.subject.otherNeurofisiologíaes_ES
dc.titleNeural correlates of retrieval of declarative memories modulated by the reconsolidation processes_ES
dc.typetesis doctoral
sipa.codpersvinculados65567
sipa.codpersvinculados119815
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