Effects of stress in the growth of microbial biofilms

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dc.catalogadoryvc
dc.contributor.advisorDüring, Gustavo
dc.contributor.authorMedina Boyd, Ignacio
dc.contributor.otherPontificia Universidad Católica de Chile. Facultad de Física
dc.date2023-04-25
dc.date.accessioned2023-01-25T15:37:22Z
dc.date.issued2023
dc.date.updated2023-01-23T19:55:50Z
dc.descriptionTesis (Master in Theoretical Physics)--Pontificia Universidad Católica de Chile, 2023
dc.description.abstractIn active matter physics, bacteria are considered active agents that grow and reproduce by division. Some bacterial strains attach to surfaces forming biofilms which exhibit complex spatial behavior, governed by the internal and external physical interactions and many biological factors. Studies have been made about the biomechanical interactions that arise in such systems, but due to the complexity of the biological mechanisms, few conclusions about the dynamics of growth and underlying physics have been drawn. In the present work, we propose a simplified two dimensional biophysical model to reduce to a minimum the number of factors that affect dynamics of the system. Using numerical methods, we explore the parameter dependence of our model, applying different boundary conditions to our numerical simulations. Internal stresses and velocities within the system show an exponential profile that defines zones of buckling and a steady front that propagates the biofilm towards unoccupied regions. By taking averages over ensembles of cells, we create a continuous description of the system and compare the continuous theory to the dynamics given by the numerical simulations. We conclude that the modelled biofilm dynamics, stresses and growth agree to the theoretical results, and the growing front presents a characteristic length defined by the interplay between dynamical viscosity and cell stiffness.
dc.description.version2023-04-25
dc.fechaingreso.objetodigital2023-01-26
dc.format.extent81 páginas
dc.fuente.origenAutoarchivo
dc.identifier.doi10.7764/tesisUC/FIS/66418
dc.identifier.urihttps://doi.org/10.7764/tesisUC/FIS/66418
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/66418
dc.information.autorucFacultad de Física ; Medina Boyd, Ignacio ; S/I ; 232166
dc.information.autorucFacultad de Física ; Düring, Gustavo ; 0000-0002-4171-5948 ; 1012766
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subject.ddc530
dc.subject.deweyMatemática física y químicaes_ES
dc.titleEffects of stress in the growth of microbial biofilmses_ES
dc.typetesis de maestría
sipa.codpersvinculados1012766
sipa.codpersvinculados232166
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