Simulation of oxygen and hypoxia PET-tracer distributions in 3D vascular architectures of tumours

Simple item page
dc.contributor.advisorKarger, Christian
dc.contributor.advisorGago Arias, Araceli
dc.contributor.authorIsabela Paredes Cisneros
dc.contributor.otherPontificia Universidad Católica de Chile. Facultad de Física
dc.date.accessioned2018-05-15T16:07:33Z
dc.date.available2018-05-15T16:07:33Z
dc.date.issued2018
dc.descriptionTesis (Master of Science)--Pontificia Universidad Católica de Chile, 2018
dc.descriptionTesis (Clinical Medical Physics)--Universität Heidelberg, 2018
dc.description.abstractThe outcome of radiotherapy is strongly influenced by hypoxia (low level of oxygenin the tumour), which leads to increased radioresistance and poor outcome. Positron Emission Tomography (PET) can be used to identify hypoxic regions within tumours. Hypoxia-specific tracers have been developed for this purpose. Deriving the tumour oxygen distribution from a hypoxia PET-tracer distribution is still not straightforward and computer simulations may help to better understand the limitations of this technique. In this thesis, hypoxia PET-tracer distributions were simulated in three dimensions by using mathematical models to calculate the spatiotemporal distributions of both oxygen and tracer in the tumour. The impact of necrosis in the tracer uptake was also considered. The partial differential equations in the model were solved, using the Finite Element Method for different vascular architectures. The correct functioning of the solving method was checked for simple architectures by changing parameter values and analysing the obtained distributions. Time-Activity Curves were calculated from the simulated concentrations and the impact of the vascular fraction was determined, for vascular architectures of different complexity. This study improves the understanding of the signal in hypoxia-PET studies. Future work should take into account even more complex vascular architectures, as well as acute hypoxia.
dc.format.extent66 páginas
dc.identifier.doi10.7764/tesisUC/FIS/21873
dc.identifier.urihttps://doi.org/10.7764/tesisUC/FIS/21873
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/21873
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherRadioterapia - Modelos matemáticoses_ES
dc.subject.otherCáncer.es_ES
dc.subject.otherAnoxia.es_ES
dc.titleSimulation of oxygen and hypoxia PET-tracer distributions in 3D vascular architectures of tumourses_ES
dc.typetesis de maestría
sipa.codpersvinculados242928
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
IsabelaParedesTesisPUC.pdf
Size:
7.61 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.31 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
3.10 Tesis magíster