Feasibility study : use of cine-MRI in MR-guided particle therapy

Simple item page
dc.contributor.advisorPfaffenberger, Asja
dc.contributor.advisorSánchez Nieto, Beatriz
dc.contributor.authorSepúlveda Muñoz, César
dc.contributor.otherPontificia Universidad Católica de Chile. Facultad de Física
dc.date.accessioned2018-10-30T20:24:45Z
dc.date.available2018-10-30T20:24:45Z
dc.date.issued2018
dc.descriptionTesis (Master in Medical Physics)--Pontificia Universidad Católica de Chile, 2018
dc.descriptionTesis (Master in Medical Physics)--University of Heidelberg, 2018
dc.description.abstractCinematic Magnetic Resonance Imaging (cine-MRI) are fast time-resolved 2D MRI sequences that allow online visualization of organ motion without exposing patients to ionizing radiation. In this study, the potential of cine-MRI for the definition of animage-based gating criterion in particle therapy of pancreatic cancer is investigated. Transversal cine-MRI are employed to segment the pancreas, since they can provide information on tissue changes in the beam-path during delivery. Volunteer data were acquired on 10 different acquisition days. An image-based gating window was defined based on the breathing-curve (BC) of the first day (end-exhale breathing phase ±30%). The superposition of the pancreas segmentations in this window was calculated. For other days of data acquisition, the agreement with this initial superposition contour was evaluated by using different segmentation image similarity metrics. Additionally, a motion analysis of the pancreas was performed. From the metrics comparisons, a gating criterion was defined to establish when irradiation can be allowed. An evaluation of the dosimetric differences due to differences in the segmentations achieving the criterion and the spatial location of the organs was carried out for a proton treatment. Although the method applied was subjected to several limitations, it was proved to be feasible.
dc.format.extent91 páginas
dc.identifier.doi10.7764/tesisUC/FIS/22138
dc.identifier.urihttps://doi.org/10.7764/tesisUC/FIS/22138
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/22138
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherImagen por resonancia magnética.es_ES
dc.titleFeasibility study : use of cine-MRI in MR-guided particle therapyes_ES
dc.typetesis de maestría
sipa.codpersvinculados192291
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Master_Thesis_CesarSep.pdf
Size:
3.76 MB
Format:
Adobe Portable Document Format
Description:
Download
Thumbnail Image
Name:
Master_Thesis_PUC_CesarSep.pdf
Size:
3.83 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.31 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
3.10 Tesis magíster