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Browsing ANID by Subject "03 Good Health and Well-being"
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- ItemA longitudinal approach for understanding algorithm use(WILEY, 2022) Chacón Hiriart, Álvaro Marcelo; Kausel, Edgar E.; Reyes Torres Tomas HernanResearch suggests that algorithms-based on artificial intelligence or linear regression models-make better predictions than humans in a wide range of domains. Several studies have examined the degree to which people use algorithms. However, these studies have been mostly cross-sectional and thus have failed to address the dynamic nature of algorithm use. In the present paper, we examined algorithm use with a novel longitudinal approach outside the lab. Specifically, we conducted two ecological momentary assessment studies in which 401 participants made financial predictions for 18 days in two tasks. Relying on the judge-advisor system framework, we examined how time interacted with advice source (human vs. algorithm) and advisor accuracy to predict advice taking. Our results showed that when the advice was inaccurate, people tended to use algorithm advice less than human advice across the period studied. Inaccurate algorithms were penalized logarithmically; the effect was initially strong but tended to fade over time. This suggests that first impressions are crucial and produce significant changes in advice taking at the beginning of the interaction, which later tends to stabilize as days go by. Therefore, inaccurate algorithms are more likely to accrue a negative reputation than inaccurate humans, even when having the same level of performance.
- ItemAssociation between obesity and atopic dermatitis in children: A case-control study in a high obesity prevalence population(2022) Iturriaga, Carolina; Bustos, María Francisca; Le Roy, Catalina; Rodríguez, Rocío; Cifuentes, Lorena; Silva-Valenzuela, Sergio; Vera-Kellet, Cristián; Cristi, Francisca; Pérez-Mateluna, Guillermo; Cabalín, Carolina; Hoyos-Bachiloglu, Rodrigo; Camargo Jr., Carlos A.; Borzutzky Schachter, ArturoBackground/Objective: Atopic dermatitis (AD) is a chronic inflammatory skin disease. Research suggests an association between obesity and AD, although evidence is lacking from Latin American populations. This study evaluated the association of obesity with AD in children from Chile, a country with high obesity prevalence. Methods: A case-control study was performed in children with active AD (cases) and healthy controls (HCs) from Santiago, Chile. Body mass index was evaluated by z-score (z-BMI), with overweight defined as z-BMI ≥+1 and <+2, and obesity as z-BMI ≥+2. Abdominal obesity was defined by a waist circumference-to-height ratio (WHR) ≥0.5. AD severity was evaluated by Scoring AD (SCORAD) index. Results: A total of 174 children with AD and 101 controls were included. AD patients had similar overweight (27% vs. 28%) and obesity (21% vs. 26%) rates as HCs (p = .65). Abdominal obesity rates were also comparable (64% vs. 62%, p = .81). In sex-specific analyses, girls with AD had higher abdominal obesity rates than HCs (71% vs. 53%, p < .05) while boys with AD had lower abdominal obesity rates than HCs (53% vs. 75%, p = .03). Among children with AD, higher z-BMI or WHR did not correlate with higher SCORAD, eosinophil counts or total IgE. Conclusion: In our study, Chilean children with AD had high but similar rates of obesity as HCs, but showed sex-specific associations of abdominal obesity and AD. Further research is needed to evaluate these associations and the roles that weight excess and weight loss could play in the pathogenesis and treatment of AD.
- ItemEucryphia cordifolia extracts: Phytochemical screening, antibacterial and antioxidant activities(2021) Viteri, Rafael; Giordano, Ady; Montenegro, Gloria; Zacconi, Flavia C. M.Eucryphia cordifolia is a native and dominant species from the Temperate Forest in the southern region of Chile. It is a crucial melliferous species producing unifloral honey with outstanding antibacterial properties with great commercial value at international markets. A phytochemical screening was developed by colorimetric and gravimetric methods. Antioxidant activities were assessed by using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and ferric ion reducing antioxidant power (FRAP) method. The minimum bactericidal concentration (MBC) was the method used to determine the antibacterial activity. The results revealed the highest antioxidant activity for the methanolic extracts of branches (IC50 35.7 mu g/mL for DPPH, IC50 11.0 mu g/mL for ABTS, and 4.6 mM FeSO4 center dot 7H(2)O/g in FRAP), attributed to its high content of total phenols (332.8 mg GAE/g). The quantification of the MBC led to values in the range of 0.78-12.5 mg/mL for S. aureus and S. pyogenes, and 6.25-50 mg/mL for E. coli and P. aeruginosa, respectively. The presented work provides valuable first in vitro evidence regarding the potential application of E. cordifolia extracts as antioxidants and antibacterial agents in the nutraceutical and phytopharmaceutical industry.
- ItemGreen by Design: Convergent Synthesis, Computational Analyses, and Activity Evaluation of New FXa Inhibitors Bearing Peptide Triazole Linking Units(2022) Rodriguez, Diego F.; Duran Osorio, Francisca; Duarte, Yorley; Olivares, Pedro; Moglie, Yanina; Dua, Kamal; Zacconi, Flavia C. M.Green chemistry implementation has led to promising results in waste reduction in the pharmaceutical industry. However, the early sustainable development of pharmaceutically active compounds and ingredients remains a considerable challenge. Herein, we wish to report a green synthesis of new pharmaceutically active peptide triazoles as potent factor Xa inhibitors, an important drug target associated with the treatment of diverse cardiovascular diseases. The new inhibitors were synthesized in three steps, featuring cycloaddition reactions (high atom economy), microwave-assisted organic synthesis (energy efficiency), and copper nanoparticle catalysis, thus featuring Earth-abundant metals. The molecules obtained showed FXa inhibition, with IC50-values as low as 17.2 mu M and no associated cytotoxicity in HEK293 and HeLa cells. These results showcase the environmental potential and chemical implications of the applied methodologies for the development of new molecules with pharmacological potential.
- ItemHertoghe’s sign in atopic dermatitis(2020) Borzutzky Schachter, Arturo; Tejos-Bravo, Macarena; Venegas, Luis F.; Iturriaga, Carolina
- ItemInternet Addiction of Older Women and Its Relationship With Social Influence and Social Networks Use as a Mediator(2022) Rosell Cisternas, Javiera; Leeson, George W.; Verges, AlvaroThe aim is to analyse the relationship between social influence for Internet use and Internet addiction (IA) in older women, considering the use of Internet-based social networks as a mediator. The participants were 480 older women Internet users. Social influence, frequency of use of social networks and IA (including loss of control and emotional dysregulation) were evaluated. Structural Equation Modeling (SEM) was conducted to analyse the proposed model. The use of social networks was a significant mediator in the relationship between social influence for Internet use and the dimension of loss of control of IA. On the contrary, social network use was not a significant mediator. Older women with more social influence reported more frequency of social networking and, in turn, more loss of control in Internet use. Public policy and clinicians should address addictive behaviours about Internet use in older women, preventing the negative consequences.
- ItemnAChR-induced octopamine release mediates the effect of nicotine on a startle response in Drosophila melanogaster(2013) Fuenzalida Uribe, Nicolás Leonardo; Meza Cárdenas, Rodrigo Alexis; Hoffmann, Hernán A.; Varas Orozco, Rodrigo; Campusano Astorga, Jorge MauricioBiogenic amines (BAs) play a central role in the generation of complex behaviors in vertebrates and invertebrates, including the fly Drosophila melanogaster. The comparative advantages of Drosophila as a genetic model to study the contribution of BAs to behaviors stumble upon the difficulty to access the fly brain to ask relevant physiological questions. For instance, it is not known whether the activation of nicotinic acetylcholine receptors (nAChRs) induces the release of BAs in fly brain, a phenomenon associated to several behaviors in vertebrates. Here, we describe a new preparation to study the efflux of BAs in the adult fly brain by in vitro chronoamperometry. Using this preparation we show that nAChR agonists including nicotine induce a fast, transient, dose-dependent efflux of endogenous BAs, an effect mediated by -bungarotoxin-sensitive nAChRs. By using different genetic tools we demonstrate that the BA whose efflux is induced by nAChR activation is octopamine (Oct). Furthermore, we show that the impairment of a mechanically induced startle response after nicotine exposure is not observed in flies deficient in Oct transmission. Thus, our data show that the efflux of BAs in Drosophila brain is increased by nAChR activation as in vertebrates, and that then AChR-induced Oct release could have implications in a nicotine-induced behavioral response.
- ItemRefractory systemic juvenile idiopathic arthritis successfully treated with rapamycin(Oxford University Press, 2021) Concha, Sara; Rey-Jurado, Emma; Poli, M. Cecilia; Hoyos-Bachiloglu, Rodrigo
- ItemThe asthma predictive index as a surrogate diagnostic tool in preschoolers: Analysis of a longitudinal birth cohort(WILEY, 2021) Castro Rodriguez, Jose A.; Forno, Erick; Padilla, Oslando; Casanello, Paola; Krause, Bernardo J.; Borzutzky Schachter, ArturoDiagnosing asthma in preschool children remains an unsolved challenge, at a time when early identification would allow for better education and treatment to prevent morbidity and lung function deterioration. Objective To evaluate if the asthma predictive index (API) can be used as surrogate for asthma diagnosis in preschoolers. Methods Birth cohort of 339 pregnant women enrolled at delivery and their offspring, who were followed for atopy, wheezing, and other respiratory illnesses through 30 months of age. The API was determined at 30 months of age by the researchers; and examined its association with physician-diagnosed asthma during the first 30 months, made independently by the primary care physician not involved in the study. Results Among 307 offspring with complete follow-up, 44 (14.3%) were API+. Maternal body mass index, maternal education, past oral contraceptive use, birthweight, placenta weight, age of daycare at 12 m, gastroesophageal reflux disease at 12 m, acute otitis media at 18 m, bronchiolitis, croup and pneumonia, cord blood adiponectin were all associated with API+. In the multivariable analysis, API+ was associated with almost sixfold odds of asthma diagnosis (adjusted OR = 5.7, 95% CI [2.6-12.3]), after adjusting for the relevant covariates above including respiratory infections like bronchiolitis and pneumonia. The API sensitivity was 48%, specificity 92%, 61% PPV, 88% NPV, 6.4 LR+, 0.56 LR-, 0.84 diagnosis accuracy. The adjusted odds for asthma was 11.4. Conclusions This longitudinal birth cohort suggests, for first time, that API (a structured definition for asthma), could be used as a diagnostic tool, not only as a prognostic tool, in toddlers and preschoolers.