Colecciones Institucionales

Permanent URI for this community

https://repositorio.uc.cl/handle/11534/1

Browse

Browsing Colecciones Institucionales by browse.metadata.fuente "ORCID;2024-01-15"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Attitudes to noise in young adults and associated factors: adaptation of the youth attitude to noise scale into Spanish using item response theory analysis
    (Taylor & Francis Ltd., 2022) Fuentes López, Eduardo; Fuente, Adrian; Luna-Monsalve, Manuel; Guajardo-Vergara, Carlos
    Objective This study aimed to identify the attitudes to noise in young adults and the possible effects of gender, age, and a positive history of auditory symptoms related to recreational noise exposure on the attitudes to noise in this population. Design The Youth Attitude to Noise (YANS) and the hearing symptom description (HSD) scales were adapted into Spanish to be used with young adults. The validity was determined using factor analyses and Item Response Theory (IRT) models. Linear regression models were used to determine whether the YANS scores were associated with gender, age, and auditory symptoms. Study sample Both instruments were given to a sample of 728 Chilean young adults. Data obtained from this sample was used to determine the YANS and HSD scales' validity and to assess the effects of gender, age, and auditory symptoms on attitudes. Results Our results showed that the YANS and HSD scales had adequate validity and reliability. Differences in the items' capacity to discriminate attitudes to noise were noted using the IRT model. Auditory symptoms were significantly associated with the YANS scores. Conclusions The attitudes to noise in Chilean young adults are influenced by self-perception of auditory symptoms, age, and gender.
  • Thumbnail Image
    Item
    Heme Oxygenase-1 Expression in Dendritic Cells Contributes to Protective Immunity against Herpes Simplex Virus Skin Infection
    (MDPI, 2023) Tognarelli Torres, Eduardo Ignacio; Duarte Peñaloza, Luisa Fernanda; Farías León, Mónica Andrea; Cancino Prado, Felipe Andrés; Corrales Bonilla, Nicolas; Ibañez Irribarra, Francisco Javier; Riedel Soria, Claudia; Bueno Ramírez, Susan; Kalergis Parra,Alexis Mikes; González Muñoz, Pablo Alberto
    Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections are highly prevalent in the human population and produce mild to life-threatening diseases. These viruses interfere with the function and viability of dendritic cells (DCs), which are professional antigen-presenting cells that initiate and regulate the host's antiviral immune responses. Heme oxygenase-1 (HO-1) is an inducible host enzyme with reported antiviral activity against HSVs in epithelial cells and neurons. Here, we sought to assess whether HO-1 modulates the function and viability of DCs upon infection with HSV-1 or HSV-2. We found that the stimulation of HO-1 expression in HSV-inoculated DCs significantly recovered the viability of these cells and hampered viral egress. Furthermore, HSV-infected DCs stimulated to express HO-1 promoted the expression of anti-inflammatory molecules, such as PDL-1 and IL-10, and the activation of virus-specific CD4(+) T cells with regulatory (Treg), Th17 and Treg/Th17 phenotypes. Moreover, HSV-infected DCs stimulated to express HO-1 and then transferred into mice, promoted the activation of virus-specific T cells and improved the outcome of HSV-1 skin infection. These findings suggest that stimulation of HO-1 expression in DCs limits the deleterious effects of HSVs over these cells and induces a favorable virus-specific immune response in the skin against HSV-1.