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Browsing Colecciones Institucionales by browse.metadata.fuente "Historial Académico"
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- ItemA Comprehensive Review of the Natural History of Helicobacter Pylori Infection Children(2000) Harris Diez, Paul Richard; Atherton, J; Gold, B; Goodman, K; Guarner, J; Madrazo de la Garza, A; Muñoz, O; Pérez-Pérez, G; Torres, J
- ItemA Escrita Como Esconjuro e Como Degradacao Do Tempo Em el Principio del Placer de Jose Emilio Pacheco(2003) Hurtado, María de la Luz
- ItemA Latin Spring? Examining digital diffusion and youth bulges in forecasting political change in Latin America(Routledge, 2014) Bachmann C., Ingrid; Groshek, Jacob; Brewer, Anita; Welp, YaninaThe story is quite different in the countries that experienced the Arab Spring, where autocratic governments were still the rule in the twenty-first century. Arguably, shifts in democratic countries would be more likely to be measured rather than major revolutions like the ones that ended up ousting Hosni Mubarak in Egypt and Ben Ali in Tunisia. Conventional wisdom suggests that mass media and media diffusion are important for public deliberation, and play an important role fostering and maintaining democracy and stable societies. Research from political science and mass communication stresses the democratizing role of media. Indeed, in the last decades both neoliberal economics and populist politics have coexisted in several Latin American countries, for both left- and right-leaning governments. On the whole, the region has gone through overall economic stabilization, although political conflicts related to poorly distributed income, high unemployment, and lack of opportunities for young and indigenous people persist in most of the countries.
- ItemA review of steel plate shear wall design requirements and research(2007) López-García D; Berman JW; Bruneau M; Vian D
- ItemActrices chilenas de frente y perfil: breve itinerario para una fisonomía notable(Ocho Libros Editores, 2016) Hurtado Merino, María De La Luz
- ItemActualizar memoria como proyecto de futuro. Prólogo(Universidad de Valparaíso, 2011) Hurtado, María de la Luz
- ItemAdaptación de la Escala Atribucional de Motivación de Logro de Manassero y Vázquez(2009) Morales Bueno, Emma Patricia; Gómez Nocetti, VivianaEn el presente artículo se reportan los resultados del estudio de validez de constructo y fiabilidad de una Escala Atribucional de Motivación de Logro (EAML), adaptada para su aplicación en contextos educativos universitarios, en los cuales se implementan estrategias de aprendizaje colaborativo. En la nueva escala (EAML-M) se reemplazó la dimensión original de Motivación de Competencia del Profesor por la dimensión Motivación de Interacción, en la cual se incorporaron aspectos relacionados con la percepción del estudiante acerca de la influencia de la interacción con sus pares y el profesor, en un contexto de aprendizaje colaborativo. La escala fue aplicada con estudiantes peruanos de primer año de ingeniería, pertenecientes a un curso que implementa la metodología de Aprendizaje Basado en Problemas (ABP). Los resultados del Análisis Factorial Exploratorio permiten identificar seis dimensiones en la nueva escala. La confiabilidad estimada es buena (α: 0,9026). Adicionalmente, el perfil dimensional obtenido muestra características que pueden orientar futuras investigaciones en esta línea.
- ItemAdvances in understanding respiratory syncytial virus infection in airway epithelial cells and consequential effects on the immune response(2013) Bueno Ramírez, Susan Marcela; Cespedes Donoso, Pablo Francisco; González, Pablo A.; Kalergis Parra, Alexis Mikes; Lay Remolcoi, Margarita Kam-len; León, Miguel A.; Riedel Soria, ClaudiaThis article reviews aspects of respiratory syncytial virus (RSV) infection in airway epithelial cells (AECs), including cytopathogenesis, entry, replication and the induction of immune response to the virus, including a new role for thymic stromal lymphopoietin in RSV immunopathology. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
- ItemAFM Study of Elastic Module of Physical-Vapor-Deposited Phospholipid Membranes(2018) Volkmann, Ulrich Georg; Catalán López, Rodrigo Esteban; Retamal Ponce, María José; Cisternas Fruns, Marcelo Andrés; Moraga Vent, Nicolás Andrés; Díaz Díaz, Diego Ignacio; Corrales, Tomás P.; Pérez-Acle, Tomás; Soto Arriaza, Marco Antonio; Huber, PatrickThe physical study of artificial phospholipid membranes on solid substrates has become a relevant way to gain insights into the physical behavior of cell membranes. The study of mechanical properties of artificial membranes (lab-made) has become possible with the use of atomic force microscopy. Here, we analyze the Young's modulus and adhesion force of several phospholipidic membranes as a function of temperature using Scanning Force Spectroscopy (SFS). Phospholipids were deposited onto double-polished silicon substrates by physical vapor deposition (PVD), as we have recently reported [1, 2]. We have used Raman spectroscopy to show that the chemical structure of our deposited phospholipid remains unaltered after PVD. After PVD we performed AFM and SFS measurements on the following phospholipids: DPPC, DMPC and DSPC. Measurements using AFM in liquid confirm the self-assembly of the phospholipid bilayer. By using SFS of the deposited membrane in liquid, we observe 2 phase transitions, both in Younǵs Modulus, as well as adhesion channels. The measured phase transitions are consistent with the ripple-gel transition and the gel-liquid crystalline phases. Furthermore, we have studied the frequency dependence of these phase transitions by changing the tip velocity in SFS experiments. Supported by FONDECYT grant # 1141105 (UGV), FONDECYT INICIACION grant # 11160664 (TPC), CONICYT Fellowships (RC and MC), Postdoctoral Fellowship FONDECYT 3160803 (MJR) and CONICYT-PIA ACT 1409. [1] María J. Retamal, Marcelo A. Cisternas, Sebastian E. Gutierrez-Maldonado, Tomas Perez-Acle, Birger Seifert, Mark Busch, Patrick Huber and Ulrich G. Volkmann, J. Chem. Phys. 141, 104201 (2014). [2] María Jose Retamal, Tomas P. Corrales, Marcelo A. Cisternas, Nicolas H. Moraga, Diego I. Diaz, Rodrigo E. Catalan, Birger Seifert, Patrick Huber, and Ulrich G. Volkmann. Biomacromolecules 17 (3), 1142 (2016).
- ItemAnálisis de la enunciación: distinciones operativas para un análisis dialógico del discurso(2007) Larraín, Antonia; Medina Morales, LorenaEl análisis de la enunciación, entendido como un tipo de análisis del discurso que concibe el discurso como siempre marcado subjetivamente, representa para las humanidades, y específicamente par la psicología, una herramienta de gran valor. No obstante lo anterior, este tipo de análisis carece de cohesión y consenso, permaneciendo como un conjunto de planteamientos aislados. Por otro lado, es un tipo de análisis escasamente difundido y poco conocido en el ámbito de las ciencias sociales. Con el fin de difundir este tipo de herramienta, el presente artículo propone un modelo de análisis (categorías y procedimientos), frutos de la discusión e integración del trabajo de sus principales exponentes: Kerbrat-Orecchioni (1993) y Ducrot (1986).
- ItemAnálisis de un proceso de práctica profesional orientado a la reflexión docente(2017) Rivas Catricheo, Hernán; Vásquez Ortiz, Claudia; Pincheira Hauck Nataly Goreti; Contreras, J. M.; Arteaga, P.; Cañadas, G. R.; Gea, M. M.; Giacomone, B.; López Martín, M. M.La reflexión sobre la práctica es reconocida como una competencia importante en losprocesos de formación inicial y continua del profesorado. En el caso de la formacióninicial, la práctica profesional constituye una instancia privilegiada para favorecer procesosreflexivos, dada la oportunidad que tienen los futuros profesores de asumir por completo elrol de profesor en espacios naturales de enseñanza. Sin embargo, se requiere contar conherramientas que orienten una reflexión fundada. En este estudio aplicamos la noción dehecho didáctico significativo en conjunto con una guía de reflexión, ambos basados en lanoción de idoneidad didáctica, con el fin de orientar el análisis y la reflexión durante unproceso de práctica profesional enfocado en la enseñanza de la matemática.
- ItemAnalysis of Multidisciplinary Collaboration in Primary Healthcare: The Chilean Case(2017) Saint-Pierre, Cecilia; Sepúlveda, Marcos; Herskovic, ValeriaAround 10% of the population suffers from diabetes, and this percentage is expected to rise. Healthcare guidelines propose a multidisciplinary, collaborative approach for treatment. However, there is little data to understand whether healthcare professionals are actually collaborating and how this collaboration takes place. We analyzed 4 years of data from 3 healthcare centers in Chile, corresponding to 2,838 patients. Patients were classified according to the composition of the healthcare team into four categories: highly multidisciplinary teams, specialized teams, physician-nurse centered teams, and non-collaborative treatment. Our results show that team prevalence is related to patient and healthcare center characteristics.
- ItemAndres Perez Vs. Rodrigo Perez: Duelo Teatral a Traves de Mishima/Sade(2002) Hurtado, María de la Luz
- ItemAntithrombotic treatments, outcomes, and prognostic factors in acute childhood-onset arterial ischemic stroke: a multicentre, observational, cohort study(2009) Hernández Chávez, Marta Isabel; Goldenberg, Neil A.; Bernard, Timothy J.; Fullerton, Heather; Gordon, Anne; Veber, Gabrielle de; International Pediatric Stroke Study Group
- ItemApplying Clustering in Process Mining to Find Different Versions of a Business Process That Changes over Time(Springer, 2012) Luengo Mundaca, Daniela Lorena; Sepúlveda Fernández, Marcos ErnestoMost Process Mining techniques assume business processes remain steady through time, when in fact their underlying design could evolve over time. Discovery algorithms should be able to automatically find the different versions of a process, providing independent models to describe each of them. In this article, we present an approach that uses the starting time of each process instance as an additional feature to those considered in traditional clustering approaches. By combining control-flow and time features, the clusters formed share both a structural similarity and a temporal proximity. Hence, the process model generated for each cluster should represent a different version of the analyzed business process. A synthetic example set was used for testing, showing the new approach outperforms the basic approach. Although further testing with real data is required, these results motivate us to deepen on this research line.
- ItemÁrboles viejos y muertos en pie: un recurso vital para la fauna del bosque templado de Chile(2012) Altamirano Oyarzún, Tomás Alberto; Ibarra Eliessetch, José Tomás; Martin, Kathy; Bonacic Salas, Cristián
- ItemBayesian Nonparametric Approaches for ROC Curve Inference(2015) Calhau Fernandes, Inacio De Carvalho Vanda; Jara, Alejandro; Bras De Carvalho, MiguelThe development of medical diagnostic tests is of great importance in clinical practice, public health, and medical research. The receiver operating characteristic (ROC) curve is a popular tool for evaluating the accuracy of such tests. We review Bayesian nonparametric methods based on Dirichlet process mixtures and the Bayesian bootstrap for ROC curve estimation and regression. The methods are illustrated by means of data concerning diagnosis of lung cancer in women.
- ItemBCG-induced cross-protection and development of trained immunity: implication for vaccine design(2019) Covián, Camila; Fernández Fierro, Ayleen Lorena; Retamal Díaz, Angello Ricardo; Díaz Acevedo, Fabián Esteban; Vásquez Veloso, Abel; Lay Remolcoi, Margarita Kam-len; Riedel Soria, Claudia; González Muñoz, Pablo Alberto; Bueno Ramírez, Susan; Kalergis Parra, Alexis MikesThe Bacillus Calmette-Guerin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease. Vaccination with BCG reduces mortality in newborns and induces an improved innate immune response against microorganisms other than Mycobacterium tuberculosis, such as Candida albicans and Staphylococcus aureus. Innate immune cells, including monocytes and natural killer (NK) cells, contribute to this non-specific immune protection in a way that is independent of memory T or B cells. This phenomenon associated with a memory-like response in innate immune cells is known as "trained immunity." Epigenetic reprogramming through histone modification in the regulatory elements of particular genes has been reported as one of the mechanisms associated with the induction of trained immunity in both, humans and mice. Indeed, it has been shown that BCG vaccination induces changes in the methylation pattern of histones associated with specific genes in circulating monocytes leading to a "trained" state. Importantly, these modifications can lead to the expression and/or repression of genes that are related to increased protection against secondary infections after vaccination, with improved pathogen recognition and faster inflammatory responses. In this review, we discuss BCG-induced cross-protection and acquisition of trained immunity and potential heterologous effects of recombinant BCG vaccines.
- ItemBiblical Techniques for the Interpretation of the Nicene Creed: the Case of Athanasius’ De synodis(Ferdinand Schöning / Brill, 2020) Fernández Eyzaguirre, Samuel José; Usacheva, Anna; Jacobsen, Anders Ch.The Trinitarian controversy of the 350s revolved around synodical texts, because the term ‘consubstantial’ (ὁμοούσιος), proclaimed by the synod of Nicaea (325), was rejected by many of the eastern bishops. For the first time in history, an important theological discussion was shaped not only by the interpretation of Scripture but also the understanding of a creed. Within this new institutional and theological context, Athanasius of Alexandria, in his work De synodis (359), made a serious attempt to establish criteria for interpreting synodical texts. The present article studies Athanasius’ effort to apply biblical hermeneutical criteria to the interpretation of synodical documents. In order to shed light on this innovative contribution of Athanasius, the article proceeds as follows: first, I review the historical and theological context of his activity; second, I examine each of the objections to the Nicaean creed and the solutions offered by the Bishop of Alexandria; finally, I explore the rationale of Athanasius’ interpretation of synodical documents and its significance for the formation of Christian discourse.
- ItemBio-analytical Assay Methods used in Therapeutic Drug Monitoring of Antiretroviral Drugs-A Review(2019) Charbe, N.; Zacconi, Flavia C. M.; Amnerkar, N.; Murtaza, R.; Tambuwala, M.; Clementi, E.Background: Several clinical trials, as well as observational statistics, have exhibited that the advantages of antiretroviral [ARV] treatment for humans with Human Immunodeficiency Virus / Acquired Immune Deficiency Syndrome HIV/AIDS exceed their risks. Therapeutic drug monitoring [TDM] plays a key role in optimization of ARV therapy. Determination of ARV's in plasma, blood cells, and other biological matrices frequently requires separation techniques capable of high effectiveness, specific selectivity and high sensitivity. High-performance liquid chromatography [HPLC] coupled with ultraviolet [UV], Photodiode array detectors [PDA], Mass spectrophotometer [MS] detectors etc. are the important quantitative techniques used for the estimation of pharmaceuticals in biological samples. Objective: This review article is aimed to give an extensive outline of different bio-analytical techniques which have been reported for direct quantitation of ARV's. This article aimed to establish an efficient role played by the TDM in the optimum therapeutic outcome of the ARV treatment. It also focused on establishing the prominent role played by the separation techniques like HPLC and UPLC along with the detectors like UV and Mass in TDM. Methods: TDM is based on the principle that for certain drugs, a close relationship exists between the plasma level of the drug and its clinical effect. TDM is of no value if the relationship does not exist. The analytical methodology employed in TDM should: 1) distinguish similar compounds; 2) be sensitive and precise and 3) is easy to use Results: This review highlights the advancement of the chromatographic techniques beginning from the HPLC-UV to the more advanced technique like UPLC-MS/MS. TDM is essential to ensure adherence, observe viral resistance and to personalize ARV dose regimens. It is observed that the analytical methods like immunoassays and liquid chromatography with detectors like UV, PDA, Florescent, MS, MS/MS and Ultra performance liquid chromatography (UPLC)-MS/MS have immensely contributed to the clinical outcome of the ARV therapy. Assay methods are not only helping physicians in limiting the side effects and drug interactions but also assisting in monitoring patient's compliance. Conclusion: The present review revealed that HPLC has been the most widely used system irrespective of the availability of more sensitive chromatographic technique like UPLC.