Browsing by Author "Wildberger, Joachim E."
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- ItemDark-blood late gadolinium enhancement cardiovascular magnetic resonance for improved detection of subendocardial scar: a review of current techniques(2021) Holtackers, Robert J.; Van De Heyning, Caroline M.; Chiribiri, Amedeo; Wildberger, Joachim E.; Botnar, René Michael; Kooi, M. E.Abstract For almost 20 years, late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) has been the reference standard for the non-invasive assessment of myocardial viability. Since the blood pool often appears equally bright as the enhanced scar regions, detection of subendocardial scar patterns can be challenging. Various novel LGE methods have been proposed that null or suppress the blood signal by employing additional magnetization preparation mechanisms. This review aims to provide a comprehensive overview of these dark-blood LGE methods, discussing the magnetization preparation schemes and findings in phantom, preclinical, and clinical studies. Finally, conclusions on the current evidence and limitations are drawn and new avenues for future research are discussed. Dark-blood LGE methods are a promising new tool for non-invasive assessment of myocardial viability. For a mainstream adoption of dark-blood LGE, however, clinical availability and ease of use are crucial.
- ItemLate Gadolinium Enhancement Cardiac Magnetic Resonance Imaging: From Basic Concepts to Emerging Methods(2022) Holtackers, Robert J.; Emrich, Tilman; Botnar, René Michael; Kooi, M. Eline; Wildberger, Joachim E.; Kreitner, K.-F.Late gadolinium enhancement (LGE) is a widely used cardiac magnetic resonance imaging (MRI) technique to diagnose a broad range of ischemic and non-ischemic cardiomyopathies. Since its development and validation against histology already more than two decades ago, the clinical utility of LGE and its span of applications have increased considerably. Methods In this review we will present the basic concepts of LGE imaging and its diagnostic and prognostic value, elaborate on recent developments and emerging methods, and finally discuss future prospects. Results Continuous developments in 3D imaging methods, motion correction techniques, water/fat-separated imaging, dark-blood methods, and scar quantification improved the performance and further expanded the clinical utility of LGE imaging. Conclusion LGE imaging is the current noninvasive reference standard for the assessment of myocardial viability. Improvements in spatial resolution, scar-to-blood contrast, and water/fat-separated imaging further strengthened its position. Key Points: LGE MRI is the reference standard for the noninvasive assessment of myocardial viability LGE MRI is used to diagnose a broad range of non-ischemic cardiomyopathies in everyday clinical practice. Improvements in spatial resolution and scar-to-blood contrast further strengthened its position Continuous developments improve its performance and further expand its clinical utility Citation Format Holtackers RJ, Emrich T, Botnar RM etal. Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging: From Basic Concepts to Emerging Methods. Fortschr Röntgenstr 2022; DOI: 10.1055/a-1718-4355.