Browsing by Author "Villarroel, Alejandra"
Now showing 1 - 4 of 4
Results Per Page
Sort Options
- ItemA simple method to assess estrogen receptor gene (ESR1) amplification in paired biopsies from primary tumor and recurrence in breast cancer patients receiving endocrine therapy(2020) Maiz, Cristóbal; Oddó, David; Alfaro, Francisca; Villarroel, Alejandra; Acevedo, Francisco; Pérez Sepulveda, Alejandra; Muñiz, Sabrina; Silva, Fernando; Valdivia, Andrés; Merino, Tomas; Pinto, Mauricio P.; Sánchez, CésarGlobally, Breast Cancer (BC) is the leading cause of cancer death among women. About 75% of patients are diagnosed with hormone-dependent tumors and are set to receive Endocrine Therapy (ET) targeting the estrogen receptor. Unfortunately, a significant proportion of these patients develops ET resistance. Still controversial, studies have proposed that Estrogen Receptor-Alpha Gene (ESR1) alterations may underlie ET resistance. Here, we describe the use of a Chromogenic in Situ Hybridization (CISH) assay for the assessment of ESR1 amplification in primary tumors and recurrences. This assay could be a useful clinical tool with therapeutic implications for estrogen receptor positive BC patients.
- ItemCan histological grade and mitotic index replace Ki67 to determine luminal breast cancer subtypes?(2018) Oddo Benavides, David; Pulgar, Dahiana; Peña, José; Acevedo Claros, Francisco Nicolás; Razmilic Valdés, Dravna Nichi; Navarro Ortega, María Elena; Camus Appuhn, Mauricio Gonzalo; Merino Lara, Tomas Rodrigo; Sánchez, César; Pérez Sepúlveda, Alejandra Andrea; Villarroel, Alejandra; Galindo, Héctor; Elgueta, Nicole; Retamal, Ignacio
- ItemPatient inflammatory status and CD4+/CD8+ intraepithelial tumor lymphocyte infiltration are predictors of outcomes in high-grade serous ovarian cancer(2018) Pinto, Mauricio P.; Balmaceda, Carlos; Bravo Castillo, María Loreto; Kato Cardemil, Sumie Rode; Villarroel, Alejandra; Owen, Gareth Ivor; Roa Strauch, Juan Carlos Enrique; Cuello F., Mauricio; Ibañez, Carolina
- ItemRisk factors for loco-regional recurrence in breast cancer patients: A retrospective study(2018) Merino Lara, Tomas Rodrigo; Ip, Teresa; Domínguez Covarrubias, Francisco José; Acevedo Claros, Francisco Nicolás; Medina Araya, Lidia; Villarroel, Alejandra; Camus Appuhn, Mauricio Gonzalo; Vinés Vásquez, Eugenio; Sánchez Rojel, César Giovanni