Browsing by Author "Villanueva, S"

Now showing 1 - 4 of 4
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    Full orbital solution for the binary system in the northern Galactic disc microlensing event Gaia16aye
    (2020) Wyrzykowski, L; Mroz, P; Rybicki, KA; Gromadzki, M; Kolaczkowski, Z; Zielinski, M; Zielinski, P; Britavskiy, N; Gomboc, A; Sokolovsky, K; Hodgkin, ST; Abe, L; Aldi, GF; AlMannaei, A; Altavilla, G; Al Qasim, A; Anupama, GC; Awiphan, S; Bachelet, E; Bakis, V; Baker, S; Bartlett, S; Bendjoya, P; Benson, K; Bikmaev, IF; Birenbaum, G; Blagorodnova, N; Blanco-Cuaresma, S; Boeva, S; Bonanos, AZ; Bozza, V; Bramich, DM; Bruni, I; Burenin, RA; Burgaz, U; Butterley, T; Caines, HE; Caton, DB; Novati, SC; Carrasco, JM; Cassan, A; Cepas, V; Cropper, M; Chruslinska, M; Clementini, G; Clerici, A; Conti, D; Conti, M; Cross, S; Cusano, F; Damljanovic, G; Dapergolas, A; D'Ago, G; de Bruijne, JHJ; Dennefeld, M; Dhillon, VS; Dominik, M; Dziedzic, J; Erece, O; Eselevich, MV; Esenoglu, H; Eyer, L; Jaimes, RF; Fossey, SJ; Galeev, AI; Grebenev, SA; Gupta, AC; Gutaev, AG; Hallakoun, N; Hamanowicz, A; Han, C; Handzlik, B; Haislip, JB; Hanlon, L; Hardy, LK; Harrison, DL; van Heerden, HJ; Hoette, VL; Horne, K; Hudec, R; Hundertmark, M; Ihanec, N; Irtuganov, EN; Itoh, R; Iwanek, P; Jovanovic, MD; Janulis, R; Jelinek, M; Jensen, E; Kaczmarek, Z; Katz, D; Khamitov, IM; Kilic, Y; Klencki, J; Kolb, U; Kopacki, G; Kouprianov, VV; Kruszynska, K; Kurowski, S; Latev, G; Lee, CH; Leonini, S; Leto, G; Lewis, F; Li, Z; Liakos, A; Littlefair, SP; Lu, J; Manser, CJ; Mao, S; Maoz, D; Martin-Carrillo, A; Marais, JP; Maskoliunas, M; Maund, JR; Meintjes, PJ; Melnikov, SS; Ment, K; Mikolajczyk, P; Morrell, M; Mowlavi, N; Mozdzierski, D; Murphy, D; Nazarov, S; Netzel, H; Nesci, R; Ngeow, CC; Norton, AJ; Ofek, EO; Pakstiene, E; Palaversa, L; Pandey, A; Paraskeva, E; Pawlak, M; Penny, MT; Penprase, BE; Piascik, A; Prieto, JL; Qvam, JKT; Ranc, C; Rebassa-Mansergas, A; Reichart, DE; Reig, P; Rhodes, L; Rivet, JP; Rixon, G; Roberts, D; Rosi, P; Russell, DM; Sanchez, RZ; Scarpetta, G; Seabroke, G; Shappee, BJ; Schmidt, R; Shvartzvald, Y; Sitek, M; Skowron, J; Sniegowska, M; Snodgrass, C; Soares, PS; van Soelen, B; Spetsieri, ZT; Stankeviciute, A; Steele, IA; Street, RA; Strobl, J; Strubble, E; Szegedi, H; Ramirez, LMT; Tomasella, L; Tsapras, Y; Vernet, D; Villanueva, S; Vince, O; Wambsganss, J; van der Westhuizen, IP; Wiersema, K; Wium, D; Wilson, RW; Yoldas, A; Zhuchkov, RY; Zhukov, DG; Zdanavicius, J; Zola, S; Zubareva, A
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    Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins
    (2006) Villanueva, S; Céspedes, C; Vio, CP
    Ischemia-induced acute renal failure (ARF) is a disorder with high morbidity and mortality. ARF is characterized by a regeneration phase, yet its molecular basis is still under study. Changes in gene expression have been reported in ARF, and some of these genes are specific for nephrogenic processes. We tested the hypothesis that the regeneration process developed after ischemia-induced ARF can be characterized by the reexpression of important regulatory proteins of kidney development. The distribution pattern and levels of nephrogenic proteins in rat kidneys after ischemia were studied by immunohistochemistry and immunoblot analysis. Ischemic damage was assessed by conventional morphology, serum creatinine, and the apoptotic markers terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) and caspase 3. The hypoxia levels induced by ischemia were assessed by specific markers: hypoxia induced factor (HIF)-1 alpha and 2-pimonidazole. In kidneys with ARF, an important initial damage was observed through periodic acid Schiff staining, by the induction of damage markers alpha-smooth muscle actin (alpha-SMA) and macrophages (ED-1) and by apoptosis induction. In agreement with diminishing renal damage at the initial reparation phase, the expression of the mesenchymal proteins vimentin, neural cell adhesion molecules (Ncam), and the epithelial markers, Pax-2, Noggin, and basic fibroblast growth factor was observed; after, in a second phase, the tubular markers bone morphogen protein 7, Engrailed, and Lim-1, as well as the transcription factors Smad and p-Smad, were observed. Additionally, the endothelial markers VEGF and Tie-2 were induced at the initial and middle stages of regeneration phase, respectively. The expression of these proteins was restricted in time and space, as well as spatially and temporally. Because all of these proteins are important in maintaining a functional kidney, these results suggest that during the regeneration process after induced hypoxia, these nephrogenic proteins can be reexpressed in a similar fashion to that observed during development, thus restoring mature kidney function.
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    Posteriorization by FGF, Wnt, and retinoic acid is required for neural crest induction
    (2002) Villanueva, S; Glavic, A; Ruiz, P; Mayor, R
    The neural crest is a unique cell population induced at the lateral border of the neural plate. Neural crest is not produced at the anterior border of the neural plate, which is fated to become forebrain. Here, the roles of BMPs, FGFs, Writs, and retinoic acid signaling in neural crest induction were analyzed by using an assay developed for investigating the posteriorization of the neural plate. Using specific markers for the anterior neural plate border and the neural crest, the posterior end of early neurula embryos was shown to be able to transform the anterior neural plate border into neural crest cells. In addition, tissue expressing anterior neural plate markers, induced by an intermediate level of BMP activity, was transformed into neural crest by posteriorizing signals. This transformation was mimicked by bFGF, Wnt-8, or retinoic acid treatment and was also inhibited by expression of the dominant negative forms of the FGF receptor, the retinoic acid receptor, and Wnt signaling molecules. The transformation of the anterior neural plate border into neural crest cells was also achieved in whole embryos, by retinoic acid treatment or by use of a constitutively active form of the retinoic acid receptor. By analyzing the expression of mesodermal markers and various graft experiments, the expression of the mutant retinoic acid receptor was shown to directly affect the ectoderm. We thereby propose a two-step model for neural crest induction. Initially, BMP levels intermediate to those required for neural plate and epidermal specification induce neural folds with an anterior character along the entire neural plate border. Subsequently, the most posterior region of this anterior neural plate border is transformed into the neural crest by the posteriorizing activity of FGFs, Wnts, and retinoic acid signals. We discuss a unifying model where lateralizing and posteriorizing signals are presented as two stages of the same inductive process required for neural crest induction. (C) 2001 Elsevier Science.
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    TOI-954 b and K2-329 b: Short-period Saturn-mass Planets that Test whether Irradiation Leads to Inflation
    (2021) Sha, LZ; Huang, CLX; Shporer, A; Rodriguez, JE; Vanderburg, A; Brahm, R; Hagelberg, J; Matthews, EC; Ziegler, C; Livingston, JH; Stassun, KG; Wright, DJ; Crane, JD; Espinoza, N; Bouchy, F; Bakos, GA; Collins, KA; Zhou, GR; Bieryla, A; Hartman, JD; Wittenmyer, RA; Nielsen, LD; Plavchan, P; Bayliss, D; Sarkis, P; Tan, TG; Cloutier, R; Mancini, L; Jordan, A; Wang, SR; Henning, T; Narita, N; Penev, K; Teske, JK; Kane, SR; Mann, AW; Addison, BC; Tamura, M; Horner, J; Barbieri, M; Burt, JA; Diaz, MR; Crossfield, IJM; Dragomir, D; Drass, H; Feinstein, AD; Zhang, H; Hart, R; Kielkopf, JF; Jensen, ELN; Montet, BT; Ottoni, G; Schwarz, RP; Rojas Henríquez, Felipe Ignacio; Nespral, D; Torres Miranda, Pascal Jose; Mengel, MW; Udry, S; Zapata, A; Snoddy, E; Okumura, J; Ricker, GR; Vanderspek, RK; Latham, DW; Winn, JN; Seager, S; Jenkins, JM; Colon, KD; Henze, CE; Krishnamurthy, A; Ting, EB; Vezie, M; Villanueva, S
    We report the discovery of two short-period Saturn-mass planets, one transiting the G subgiant TOI-954 (TIC 44792534, V = 10.343, T = 9.78) observed in TESS sectors 4 and 5 and one transiting the G dwarf K2-329 (EPIC 246193072, V = 12.70, K = 10.67) observed in K2 campaigns 12 and 19. We confirm and characterize these two planets with a variety of ground-based archival and follow-up observations, including photometry, reconnaissance spectroscopy, precise radial velocity, and high-resolution imaging. Combining all available data, we find that TOI-954 b has a radius of 0.852(-0.062)(+0.053) R-J and a mass of 0.174(-0.017)(+0.018) M-J and is in a 3.68 day orbit, while K2-329 b has a radius of 0.774(-0.024)(+0.026) R-J and a mass if 0.260(-0.022)(+0.020) M-J and is in a 12.46 day orbit. As TOI-954 b is 30 times more irradiated than K2-329 b but more or less the same size, these two planets provide an opportunity to test whether irradiation leads to inflation of Saturn-mass planets and contribute to future comparative studies that explore Saturn-mass planets at contrasting points in their lifetimes.