DSpace Angular :: Browsing by Author "Verdejo, Hugo"

Browsing by Author "Verdejo, Hugo"

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AMBIENT FINE PARTICULATE MATTER IS ASSOCIATED WITH RISK OF HOSPITALIZATION FOR ACUTE DECOMPENSATED HEART FAILURE AMONG PATIENTS WITH DEPRESSED LEFT VENTRICULAR EJECTION FRACTION
(ELSEVIER SCIENCE INC, 2011) Castro, Pablo; Verdejo, Hugo; Vera, Jeantte; Cifuentes, Luis; Concepcion, Roberto; Seplveda, Luis; Vukasovic, Jose Luis; Wellenius, Gregory
Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro
(LIPPINCOTT WILLIAMS & WILKINS, 2010) Paz Ocaranza, Maria; Lavandero, Sergio; Jalil, Jorge E.; Moya, Jaqueline; Pinto, Melissa; Novoa, Ulises; Apablaza, Felipe; Gonzalez, Leticia; Hernandez, Carol; Varas, Manuel; Lopez, Rene; Godoy, Ivan; Verdejo, Hugo; Chiong, Mario
Background Angiotensin-(1-9) is present in human and rat plasma and its circulating levels increased early after myocardial infarction or in animals treated with angiotensin-converting enzyme inhibitor. However, the cardiovascular effects of this peptide are unknown.
Cambios en el pronóstico a largo plazo de la hipertensión arterial pulmonar
(SOC MEDICA SANTIAGO, 2011) Enriquez, Andres; Castro, Pablo; Sepulveda, Pablo; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Ferrada, Marcela; Lapostol, Carolina
Background: Pulmonary artery hypertension (PAR) is a progressive disease with high mortality. Major advances had been made in the treatment of this condition during the last decade. Aim: To characterize the clinical evolution and mortality of a cohort of Chilean patients. Material and Methods: Seventeen patients with PAH diagnosed in the last 10 years in two Chilean hospitals were enrolled. Measurements at diagnosis included hemodynamic variables and 6-minute walk test. The patients were followed clinically for 3 years and the observed mortality was compared with that predicted by the prognostic equation proposed by the historic registry of the National Institutes of Health (NIH). Results: The mean age of patients was 45 years and 80% had an idiopathic PAH. The mean median pulmonary artery pressure was 57 +/- 15 mmHg, the cardiac index was 2.4 +/- 0.7 l/min/m(2) and the right atrial pressure was 12 +/- 8 mmHg. The 6-minute walk distance was 348 +/- 98 m. All patients received anticoagulants. Eighty two percent received ambrisentan, 12% received bosentan, 29% received iloprost and 24% sildenafil. At the end of follow-up only 3 patients had died, with an observed survival rate of 88, 82 and 82% at 1, 2 and 3 years, respectively. In contrast, the survival calculated according to the predictive formula of the NIH was 67, 56 and 45%, respectively. Among surviving patients, an improvement in exercise capacity was observed after one year (p < 0.05). Conclusions: The observed survival rate was significantly better than that estimated according to historical data. Furthermore, therapy was associated with an improvement in functional capacity after one year. This prognostic improvement is consistent with data of other contemporary registries published after the NIH Registry. (Rev Med Chile 2011; 139: 327-333).
Cardiac dyssynchrony correlates with left ventricular remodeling after myocardial infarction
(SOC MEDICA SANTIAGO, 2009) McNab, Paul; Castro, Pablo; Gabrielli, Luigi; Verdejo, Hugo; Carlos Quintana, Juan; Rodriguez, Jose A.; Corbalan, Ramon
Background: Cardiac dyssynchrony is common in advanced heart failure (HF), but the changes in cardiac synchrony after myocardial infarction (MI) have not been adequately described. Aim: To study the relationship between cardiac synchrony and left ventricular remodeling after acute myocardial infarction. Material and methods: Forty nine patients aged 59+/-10 years (77% men) with a first episode of a ST segment elevation MI were studied. Scintigraphic left ventricular function and synchrony analyses were performed at baseline and after a six months follow-up. Determinations were compared with 33 healthy subjects. Results: At baseline, patients with MI had a decreased left ventricular ejection fraction (LVEF) and significant dyssynchrony, when compared with controls. LVEF was 36.4%+/-10%, left ventricular end-diastolic volume (LVEDV) 127+/-38 mL, interventricular delay (IEV) 29+/-35 milliseconds (ms), and intraventricular delay (IAV), 234+/-89 ms. After 6 months, LVEF significantly improved (38%+/-10%, p = 0.042) without significant changes in LVEDV (129+/-32 mL, p = 0.97), IEV (24+/-17, p = 0.96) or IAV (231 +/- 97, p = 0.34). At baseline there were significant correlations between IAV and LVEF, and between IAV and LVEDV (r = -0.48, p = 0.001 and r = -0.41, p = 0.004, respectively). These correlations remained significant after 6 months. There was a positive correlation between IAV and LVEDV changes at six months (r = 0.403, p = 0.04). Conclusions: The development of cardiac dyssynchrony correlates with adverse left ventricular remodeling after MI (Rev Med Chile 2009; 137: 1457-62).
Effects of atorvastatin therapy in heart failure: Oxidative stress, inflammation, endothelial dysfunction and exercise capacity
(ELSEVIER SCIENCE INC, 2007) Miranda, Rodrigo; Castro, Pablo; Verdejo, Hugo; Greig, Douglas; Alcaino, Hernan; Bustos, Carlos; Vukasovic, Jose Luis; Godoy, Ivan; Diaz Araya, Guillermo; Lavandero, Sergio
Expression of Herpud1 during osteoclast and osteoblast differentiation
(FEDERATION AMER SOC EXP BIOL, 2016) Quiroga, Clara; Da Silva, Luan Americo; Mansilla, Georthan; Oyarzun, Ingrid; Bustamante, Mario; Castro, Pablo; Verdejo, Hugo
Fine Particulate Air Pollution (PM2.5) Increases Emergency Hospital Admissions due to Decompensate Heart Failure
(LIPPINCOTT WILLIAMS & WILKINS, 2009) Vera, Jeanette; Castro, Pablo; Cifuentes, Luis; Wellenius, Gregory; Verdejo, Hugo; Luis Vukasovic, Jose
Galectin-3 levels in patients hospitalized for decompensated heart failure
(SOC MEDICA SANTIAGO, 2017) Rossel, Victor; Diaz Toro, Felipe; Verdejo, Hugo; Concepcion, Roberto; Sepulveda, Luis; Castro, Pablo; Luis Vukasovic, Jose; Bernales, Angie; Representacion Departmento Insufic
Galectin-3 (Gal-3) is a mediator of myocardial fibrosis involved in cardiac remodeling and a potential new prognosis marker in heart failure (HF). Aim: To measure Gal-3 at the moment of discharge in patients hospitalized for HF and its association with different variables. Material and Methods: Patients hospitalized for decompensated HF from four hospitals between August 2014 and March 2015, were included. Demographic, clinical and laboratory variables were recorded at the time of admission. At discharge, a blood sample was withdrawn to measure Gal-3 and brain natriuretic propeptide (Pro-BNP). Patients were separated in two groups, according to the level of Gal-3 (using a cutoff value of 17.8 ng/mL), comparing clinical and laboratory values between groups. Results: We included 52 patients with HF aged 70 17 years (42% females). Functional capacity was III-IV in 46% of patients and the ejection fraction was 34.9 13.4%. Pro-BNP values at discharge were 5,323 8,665 pg/mL. Gal-3 values were 23.8 16.6 ng/mL. Sixty percent of patients had values over 17.8 ng/mL. Those with elevated Gal-3 levels were older (75 16 and 62 15 years, respectively, p = 0.025) and were hypertensive in a higher proportion (90.5% and 57.1% respectively, p = 0.021). Conclusions: In patients hospitalized for HF, Gal-3 levels are higher in older and hypertensive subjects.
Inner mitochondrial membrane structure and fusion dynamics are altered in senescent human iPSC-derived and primary rat cardiomyocytes
(Elsevier B.V., 2023) Morris, Silke; Busch, Karin B.; Molina Riquelme, Isidora; Barrientos, Gonzalo; Bravo, Francisco; Aedo, Geraldine; Gómez, Wileidy; Lagos, Daniel; Eisner Sagues Veronica Raquel; Verdejo, Hugo; Peischard, Stefan; Seebohm, Guiscard; Psathaki, Olympia E.
Dysfunction of the aging heart is a major cause of death in the human population. Amongst other tasks, mitochondria are pivotal to supply the working heart with ATP. The mitochondrial inner membrane (IMM) ultrastructure is tailored to meet these demands and to provide nano-compartments for specific tasks. Thus, function and morphology are closely coupled. Senescent cardiomyocytes from the mouse heart display alterations of the inner mitochondrial membrane. To study the relation between inner mitochondrial membrane architecture, dynamics and function is hardly possible in living organisms. Here, we present two cardiomyocyte senescence cell models that allow in cellular studies of mitochondrial performance. We show that doxorubicin treatment transforms human iPSC-derived cardiomyocytes and rat neonatal cardiomyocytes in an aged phenotype. The treated cardiomyocytes display double-strand breaks in the nDNA, have ?-galactosidase activity, possess enlarged nuclei, and show p21 upregulation. Most importantly, they also display a compromised inner mitochondrial structure. This prompted us to test whether the dynamics of the inner membrane was also altered. We found that the exchange of IMM components after organelle fusion was faster in doxorubicin-treated cells than in control cells, with no change in mitochondrial fusion dynamics at the meso-scale. Such altered IMM morphology and dynamics may have important implications for local OXPHOS protein organization, exchange of damaged components, and eventually the mitochondrial bioenergetics function of the aged cardiomyocyte.
Inner mitochondrial membrane ultrastructure adaptations in the aging heart
(ELSEVIER, 2022) Molina-Riquelme, Isidora; Gomez, Wileidy; Barrientos, Gonzalo; Diaz-Castro, Francisco; del Campo-Sefir, Andrea; Garrido, Luis; Morris, Silke; Breitsprecher, Leonhard; Psathaki, Katherina; Verdejo, Hugo; Busch, Karin B.; Eisner, Veronica
Mitochondrial cristae ultrastructure adaptations in the senescent heart
(CELL PRESS, 2022) Barrientos, Gonzalo; Molina, Isidora E.; Gomez, Wileidy; Diaz-Castro, Francisco; delCampo-Sefir, Andrea; Garrido, Luis; Morris, Silke; Psathaki, Katherina; Verdejo, Hugo; Busch, Karin B.; Eisner, Veronica
Myocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure
(SOC MEDICA SANTIAGO, 2010) Luis Winter, Jose; Castro, Pablo; Meneses, Luis; Chalhub, Monica; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Chiong, Mario; Concepcion, Roberto; Mellado, Rosemarie; Hernandez, Claudia; Uribe, Sergio; Lavander, Sergio
Background: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by cardiomyocytes, associated with decreased deposits of high-energy phosphates (creatine phosphate/ creatine transporter). Magnetic resonance (MR) imaging allows a direct and noninvasive assessment of myocardial metabolites. Aim: To measure myocardial creatine and lipids by MR spectroscopy among patients with HE Material and Methods: Cardiac MR spectroscopy (1.5 Tesla) with Hydrogen antenna and single voxel acquisition was performed in five patients with non-ischemic heart failure, aged 58 +/- 9.7 years, (60% males) and 5 healthy volunteers matched for age and sex. We analyzed the signals of creatine (Cr), lipids (L) and water (W) in the interventricular septum, establishing the water/lipid (W/L) and water/creatine (W/Cr) index to normalize the values obtained. Results: Among patients, left ventricular ejection fraction was 32 +/- 6.9%, 60% were in functional capacity II, 60% had hypertension and one was diabetic. Spectroscopic curves showed a depletion of total Cr, evidenced by the W/Cr index, among patients with heart failure, when compared with healthy controls (1.46 +/- 1.21 and 5.96 +/- 2.25 respectively, p < 0,05). Differences in myocardial lipid content, measured as the W/L index, were not significant (5.06 +/- 2.66 and 1.80 +/- 1.62 respectively, p = 0.08). Conclusions: Among patients with heart failure of non-ischemic etiology, there is a depletion of creatine levels measured by MR spectroscopy. (Rev Med Chile 2010; 138: 1475-1479).
Radiofrequency based wireless pressure sensor is a reliable method for hemodynamic assessment in ambulatory chronic heart failure patients: Comparison to swan-ganz catheter and echocardiography.
(ELSEVIER SCIENCE INC, 2007) Castro, Pablo; Verdejo, Hugo; Bourge, Robert; Concepcion, Roberto; Ferrada, Marcela; Martinez, Alejandro; Alcaino, Milton; Alfaro, Mario; Godoy, Ivan; Perrone, Sergio
Relationship between mechanical and metabolic dyssynchrony with left bundle branch block: Evaluation by 18-fluorodeoxyglucose positron emission tomography in patients with non-ischemic heart failure
(ELSEVIER SCIENCE INC, 2012) Castro, Pablo; Luis Winter, Jose; Verdejo, Hugo; Orellana, Pilar; Carlos Quintana, Juan; Greig, Douglas; Enriquez, Andres; Sepulveda, Luis; Concepcion, Roberto; Sepulveda, Pablo; Rossel, Victor; Chiong, Mario; Garcia, Lorena; Lavandero, Sergio
BACKGROUND: Ventricular dyssynchrony is a common finding in patients with heart failure (HF), especially in the presence of conduction delays. The loss of ventricular synchrony leads to progressive impairment of contractile function, which may be explained in part by segmental abnormalities of myocardial metabolism. However, the association of these metabolic disarrangements with parameters of ventricular dyssynchrony and electrocardiography (ECG) findings has not yet been studied.
Role of HERPUD1 and ERAD activation during differentiation and mineralization of osteoblast in vitro
(WILEY, 2017) Americo Da Silva, Luan; Diaz, Jheimmy; Bustamante, Mario; Mancilla, Georthan; Oyarzun, Ingrid; Memmel, Mia; Verdejo, Hugo; Quiroga, Clara

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