Browsing by Author "Venegas, Alejandro"
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- ItemAttenuated Salmonella typhimurium encoding the HpaA antigen of Helicobacter pylori elicit a Th1 and Th2 immune response(2007) Serrano Honeyman, Carolina Andrea; Olmos, Marco; Bruce, Elsa; Martinez, Patricio; Torres, Javiera; Venegas, Alejandro; Harris Diez, Paul Richard
- ItemGastric cancer is related to early Helicobacter pylori infection in a high-prevalence country(AMER ASSOC CANCER RESEARCH, 2007) Ferreccio, Catterina; Rollan, Antonio; Harris, Paul R.; Serrano, Carolina; Gederlini, Alessandra; Margozzini, Paula; Gonzalez, Claudia; Aguilera, Ximena; Venegas, Alejandro; Jara, AlejandroBackground and Aims: Chile ranks fifth in the world among countries with the highest incidence of gastric cancer. The aim was to quantify the association between Helicobacter pylori infection and gastric cancer mortality at the county of residence.
- ItemHelicobacter pylori Displays Differential Iron Regulated Gene Expression Depending on Iron Status of Their Host(2012) Serrano Honeyman, Carolina Andrea; Villagran Torres, Andrea Alejandra; Cofre Dougnac, Colomba Del Carmen; Álvarez Espinoza, Manuel Alejandro; Venegas, Alejandro; Toledo, Hector; Harris Diez, Paul Richard
- ItemHelicobacter pylori vacA virulence factor in uncultured Helicobacter heilmannii sensu lato from an infected child(2016) Hernandez, Caroll; Serrano Honeyman, Carolina; Villagran, Andrea; Torres Montes, Paula Javiera; Venegas, Alejandro; Harris D., Paul R.; Hernandez, Caroll; Serrano Honeyman, Carolina; Villagran, Andrea; Torres Montes, Paula Javiera; Venegas, Alejandro; Harris D., Paul R.
- ItemInterleukin-1 beta and Tumor Necrosis Factor-alpha Polymorphisms as Iron Deficiency Risk Markers in Helicobacter pylori-Infected Children(2012) Serrano Honeyman, Carolina Andrea; Villagrán Torres, Andrea Alejandra; Venegas, Alejandro; Toledo, Hector; Crabtree, Jean E.; Harris Diez, Paul Richard
- ItemPex3p-Dependent Peroxisomal Biogenesis Initiates in the Endoplasmic Reticulum of Human Fibroblasts(WILEY-BLACKWELL, 2009) Toro, Andres A.; Araya, Claudia A.; Cordova, Gonzalo J.; Arredondo, Cristian A.; Cardenas, Hugo G.; Moreno, Regina E.; Venegas, Alejandro; Koenig, Cecilia S.; Cancino, Jorge; Gonzalez, Alfonso; Santos, Manuel J.The mechanisms of peroxisomal biogenesis remain incompletely understood, specially regarding the role of the endoplasmic reticulum (ER) in human cells, where genetic disorders of peroxisome biogenesis lead to Zellweger syndrome (ZS). The Pex3p peroxisomal membrane protein (PMP) required for early steps of peroxisome biogenesis has been detected in the ER in yeast but not in mammalian cells. Here, we show that Pex3p-GFP expressed in a new ZS cell line (MR), which lacks peroxisomes due to a mutation in the PEX3 gene, localizes first in the ER and subsequently in newly formed peroxisomes. Pex3p bearing an artificial N-glycosylation site shows an electrophoretic shift indicative of ER targeting while en route to preformed peroxisomes in normal fibroblast. A signal peptide that forces its entry into the ER does not eliminate its capability to drive peroxisome biogenesis in ZS cells. Thus, Pex3p is able to drive peroxisome biogenesis from the ER and its ER pathway is not privative of ZS cells. Cross-expression experiments of Pex3p in GM623 cells lacking Pex16p or Pex16p in MR cells lacking Pex3p, showed evidence that Pex3p requires Pex16p for ER location but: is dispensable for the ER location of Pex16p. These results indicate that Pex3p follows the ER-to-peroxisomal route in mammalian cells and provides new clues to understand its function. J. Cell. Biochem. 107: 10831096, 2009. (C) 2009 Wiley-Liss, Inc.