Browsing by Author "Velarde, Victoria"
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- ItemAngiotensin II-Induced Mesangial Cell Damage Is Preceded by Cell Membrane Permeabilization Due to Upregulation of Non-Selective Channels(2018) Gomez, Gonzalo, I; Fernandez, Paola; Velarde, Victoria; Sáez, Juan Carlos
- ItemChronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition(2018) Krause, Bernardo J.; Casanello Toledo, Paola Cecilia; Dias, Ana C.; Arias, Paulina; Velarde, Victoria; Arenas Menéndez, German Alberto; Preite, Marcelo Daniel; Iturriaga Agüera, Rodrigo
- ItemConnexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function(2018) Sáez, Juan Carlos; Contreras-Duarte, Susana; Gomez, Gonzalo I.; Labra, Valeria C.; Santibanez, Cristian A.; Gajardo Gómez, Rosario; Avendano, Beatriz C.; Diaz, Esteban F.; Montero, Trinidad D.; Velarde, Victoria; Orellana Roca, Juan Andrés
- ItemCyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure(SOC BIOLGIA CHILE, 2012) Villanueva, Sandra; Escobar, Pia; Jacubovsky, Ioram; Irarrazabal, Carlos; Carreno, Juan E.; Erpel, Jose M.; Cespedes, Carlos; Gonzalez, Alexis A.; Vio, Carlos P.; Velarde, VictoriaAcute renal failure (ARF) can be caused by injuries that induce tissue hypoxia, which in turn can trigger adaptive or inflammatory responses. We previously showed the participation of basic fibroblast growth factor (FGF-2) in renal repair. Based on this, the aim of this study was to analyze the effect of FGF-2 signaling pathway manipulation at hypoxia-induced protein levels, as well as in key proteins from the vasoactive systems of the kidney. We injected rat kidneys with FGF-2 recombinant protein (r-FGF) or FGF-2 receptor antisense oligonucleotide (FGFR2-ASO) after bilateral ischemia, and evaluated the presence of iNOS, EPO and HO-1, in representation of hypoxia-induced proteins, as well as COX-2, renin, kallikrein, and B2KR, in representation of the vasoactive systems of the kidney. A reduction in iNOS, HO-1, EPO, renin, kallikrein, B2KR, and in renal damage was observed in animals treated with r-FGF. The opposite effect was found with FGF-2 receptor down-regulation. In contrast, COX-2 protein levels were higher in kidneys treated with r-FGF and lower in those that received FGFR2-ASO, as compared to saline treated kidneys. These results suggest that the protective role of FGF-2 in the pathogenesis of ARF induced by I/R is a complex process, through which a differential regulation of metabolic pathways takes place.
- ItemEPAC expression and function in cardiac fibroblasts and myofibroblasts(2013) Olmedo, Ivonne; Muñoz, Claudia; Guzmán, Nancy; Catalán, Mabel; Vivar, Raúl; Ayala, Pedro; Humeres, Claudio; Aránguiz, Pablo; García, Lorena; Velarde, Victoria; Díaz Araya, Guillermo
- ItemThe streptozotocin-high fat diet induced diabetic mouse model exhibits severe skin damage and alterations in local lipid mediators(2018) Leguina-Ruzzi, Alberto; Ortiz, Rina; Velarde, Victoria