Browsing by Author "Varas Orozco, Rodrigo"
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- ItemATP- and ACh-induced responses in isolated cat petrosal ganglion neurons.(2007) Alcayaga, C.; Varas Orozco, Rodrigo; Valdés de Petris, Viviana Daniela.; Cerpa Jeria, Veronica Elizabeth; Iturriaga Agüera, Rodrigo
- ItemContribution of TASK-like potassium channels to the enhanced rat carotid body responsiveness to hypoxia.(2012) Ortiz Cisternas, Fernando Andrés.; Río Troncoso, Rodrigo Andre del; Varas Orozco, Rodrigo; Iturriaga Agüera, Rodrigo
- ItemElectrical and pharmacological properties of petrosal ganglion neurons that innervate the carotid body(2007) Iturriaga Agüera, Rodrigo; Varas Orozco, Rodrigo; Alcayaga Urbina, Julio Andrés
- ItemElectrophysiological Characterization of Nicotinic Acetylcholine Receptors in Cat Petrosal Ganglion Neurons in Culture: Effects of Cytisine and Its Bromo Derivatives(2006) Varas Orozco, Rodrigo; Iturriaga Agüera, Rodrigo; Alcayaga Urbina, Julio Andrés
- ItemFunctional expression of the alpha 7 and alpha 4-containing nicotinic acetylcholine receptors on the neonatal rat carotid body(2012) Meza Cárdenas, Rodrigo Alexis.; Ortiz Cisternas, Fernando Andrés.; Varas Orozco, Rodrigo
- ItemInhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia(2013) Ortiz Cisternas, Fernando Andrés.; Río Troncoso, Rodrigo Andre del; Varas Orozco, Rodrigo; Iturriaga Agüera, Rodrigo
- ItemIonic currents and action potential induced by electrical stimulation, ACh and ATP in petrosal ganglion neurons(2001) Varas Orozco, Rodrigo; Iturriaga Agüera, Rodrigo; Alcayaga, C.; Cerpa, V.; Alcayaga Urbina, Julio Andrés
- ItemMuscarinic modulation of TASK-like background potassium channel in rat carotid body chemoreceptor cells(2010) Ortiz Cisternas, Fernando Andrés.; Varas Orozco, Rodrigo
- ItemnAChR-induced octopamine release mediates the effect of nicotine on a startle response in Drosophila melanogaster(2013) Fuenzalida Uribe, Nicolás Leonardo; Meza Cárdenas, Rodrigo Alexis; Hoffmann, Hernán A.; Varas Orozco, Rodrigo; Campusano Astorga, Jorge MauricioBiogenic amines (BAs) play a central role in the generation of complex behaviors in vertebrates and invertebrates, including the fly Drosophila melanogaster. The comparative advantages of Drosophila as a genetic model to study the contribution of BAs to behaviors stumble upon the difficulty to access the fly brain to ask relevant physiological questions. For instance, it is not known whether the activation of nicotinic acetylcholine receptors (nAChRs) induces the release of BAs in fly brain, a phenomenon associated to several behaviors in vertebrates. Here, we describe a new preparation to study the efflux of BAs in the adult fly brain by in vitro chronoamperometry. Using this preparation we show that nAChR agonists including nicotine induce a fast, transient, dose-dependent efflux of endogenous BAs, an effect mediated by -bungarotoxin-sensitive nAChRs. By using different genetic tools we demonstrate that the BA whose efflux is induced by nAChR activation is octopamine (Oct). Furthermore, we show that the impairment of a mechanically induced startle response after nicotine exposure is not observed in flies deficient in Oct transmission. Thus, our data show that the efflux of BAs in Drosophila brain is increased by nAChR activation as in vertebrates, and that then AChR-induced Oct release could have implications in a nicotine-induced behavioral response.
- ItemNeonicotinic analogues: Selective antagonists for alpha 4 beta 2 nicotinic acetylcholine receptors(2013) Faúndez-Parraguez, M.; Varas Orozco, Rodrigo
- ItemSerotonin Receptors Expressed in Drosophila Mushroom Bodies Differentially Modulate Larval Locomotion(2014) Silva Bustos, Bryon Arnaldo; Goles Varela, Nicolás Ignacio; Varas Orozco, Rodrigo; Campusano Astorga, Jorge Mauricio
- ItemSustained Hypoxia Enhances TASK-like Current Inhibition by Acute Hypoxia in Rat Carotid Body Type-I Cells(2009) Ortíz, F.; Iturriaga Agüera, Rodrigo; Varas Orozco, Rodrigo