Browsing by Author "Varas, J."

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    HIGH FAT DIET IN MICE INDUCES ENDOPLASMIC RETICULUM STRESS IN LIVERS OF THEIR OFFSPRING
    (W B SAUNDERS CO LTD, 2015) Garces, M.; Chavez, J. L.; Villalobos Labra, R.; Westermeier, F.; Saez, P. J.; Salas Perez, F.; Cautivo, K.; Busso, D.; Varas, J.; Martin, S. San; Sobrevia, L.; Farias Jofre, M.
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    Impact of a simulated laparoscopic training program in a three-year general surgery residency
    (2019) Tejos, R.; Avila, R.; Inzunza, M.; Achurra Tirado, Pablo; Castillo, R.; Romberg, A.; Cordero, O.; Kusanovich Borquez, Rodrigo José; Bellolio R., Felipe; Varas, J.; Martinez, J.
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    Sedimentation rate of settleable particulate matter in Santiago city, Chile
    (2020) Morales Casa, Verónica Elizabeth; Barraza Saavedra, Francisco Javier; Collante, E.; Ginocchio Cea, Rosanna; Jorquera González, Héctor Iván Joaquín; Lambert, Fabrice; Ospina, E.; Sáez-Navarrete, C.; Varas, J.
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    Simulated training program in abdominal paracentesis for undergraduate medical students,Programa de entrenamiento simulado en paracentesis abdominal para estudiantes de medicina de pregrado
    (2019) Tejos, R.; Chahuán, J.; Uslar, T.; Inzunza, M.; Villagrán, I.; Riquelme, V.; Padilla, O.; Pizarro, M.; Corvetto, M.; Varas, J.; Riquelme, A.
    Background and aims: Abdominal paracentesis is an area that every general physician should know about, and the current learning model is unsafe for patients. Simulation allows students to develop their skills prior to clinical confrontation with minimal risks. The aims of this study were to design and evaluate a paracentesis simulation workshop for undergraduate students.
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    The challenge of medication adherence to reduce cardiovascular risk in primary care: a mixed design multi-center study in underserved populations
    (2023) Püschel, K.; González, Karla; Varas, J.; Sateler, J.; Aravena, H.; Greig, D.; Escalona, G.; Palominos, M.; Rioseco, A.; Cea, A.; Thompson, B.
    Background Cardiovascular disease is a leading cause of death in Latin America. Internationally, low medication adherence is associated with 15% to 40% of excess cardiovascular deaths. In Latin America, the magnitude of low medication adherence and the factors associated with it, are not well known, especially among socially vulnerable populations. The aim of this study is to estimate the magnitude and associated factors of low medication adherence in a socially vulnerable population with high cardiovascular risk in Chile. Methods The study is based on a mixed-methods design. It included a multicenter cross-sectional design of a randomly selected clinical population of 900 participants, and a qualitative design based on the analytical framework model, that included patients and health team members, from three primary care clinics in Chile. Results Only 24.6% from the 886 (out of 900) patients who completed the study had “high” medication adherence, 24.9% had “regular,” and 50.4% had “low” adherence. Depression was the main factor associated with regular and low adherence combined (OR: 2.12; 95%CI:1.55-2.89). Confusion and tiredness were identified as barriers for adherence. Main facilitators reported by patients included better understanding of the medications, and availability of reminders. Clearer information and family support were identified by team members as initiators for improving adherence. Conclusion Low medication adherence is highly prevalent among patients with high cardiovascular risk in a low-income population in Chile. Quantitatively, depression was a significant risk factor for regular and low adherence; qualitatively, confusion and tiredness were identified as barriers. Clearer information and family support are identified as potential facilitators.
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    Tidal volume is a major determinant of cyclic recruitment-derecruitment in acute respiratory distress syndrome
    (EDIZIONI MINERVA MEDICA, 2011) Bruhn, A.; Bugedo, D.; Riquelme, F.; Varas, J.; Retamal, J.; Besa, C.; Cabrera, C.; Bugedo, G.
    Background. Overdistension and cyclic recruitment-derecruitment contribute to ventilator-induced lung injury. High tidal volumes are thought to increase mortality mainly by inducing overdistension. However, experimental evidence suggests that tidal volume (VT) may also influence cyclic recruitment-derecruitment. Our main goal was to determine whether high tidal volumes increase cyclic recruitment-derecruitment in acute respiratory distress syndrome (ARDS) patients, as measured by dynamic computed tomography (CT).