Browsing by Author "Valenzuela, Guillermo"
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- ItemA Cloud-based Mobile System for Improving Vital Signs Monitoring During Hospital Transfers(2015) Neyem, Andrés; Valenzuela, Guillermo; Risso, Nicolas; Rojas Riethmuller, Juan S.; Benedetto Causa, José Ignacio; Carrillo, Marie J.
- ItemCoagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation.(2019) Arce, Maximiliano; Pinto, Mauricio P.; Galleguillos, Macarena; Muñoz, Catalina; Lange, Soledad; Ramirez, Carolina; Erices, Rafaela; Gonzalez, Pamela; Velasquez, Ethel; Tempio, Fabián; Lopez, Mercedes N.; Salazar-Onfray, Flavio; Cautivo, Kelly; Kalergis, Alexis M.; Cruz, Sebastián; Lladser, Álvaro; Lobos-González, Lorena; Valenzuela, Guillermo; Olivares, Nixa; Sáez, Claudia; Koning, Tania; Sánchez, Fabiola A.; Fuenzalida, Patricia; Godoy, Alejandro; Contreras Orellana, Pamela; Leyton, Lisette; Lugano, Roberta; Dimberg, Anna; Quest, Andrew F.G.; Owen, Gareth I.Hypercoagulable state is linked to cancer progression; however, the precise role of the coagulation cascade is poorly described. Herein, we examined the contribution of a hypercoagulative state through the administration of intravenous Coagulation Factor Xa (FXa), on the growth of solid human tumors and the experimental metastasis of the B16F10 melanoma in mouse models. FXa increased solid tumor volume and lung, liver, kidney and lymph node metastasis of tail-vein injected B16F10 cells. Concentrating on the metastasis model, upon coadministration of the anticoagulant Dalteparin, lung metastasis was significantly reduced, and no metastasis was observed in other organs. FXa did not directly alter proliferation, migration or invasion of cancer cells in vitro. Alternatively, FXa upon endothelial cells promoted cytoskeleton contraction, disrupted membrane VE-Cadherin pattern, heightened endothelial-hyperpermeability, increased inflammatory adhesion molecules and enhanced B16F10 adhesion under flow conditions. Microarray analysis of endothelial cells treated with FXa demonstrated elevated expression of inflammatory transcripts. Accordingly, FXa treatment increased immune cell infiltration in mouse lungs, an effect reduced by dalteparin. Taken together, our results suggest that FXa increases B16F10 metastasis via endothelial cell activation and enhanced cancer cell-endothelium adhesion advocating that the coagulation system is not merely a bystander in the process of cancer metastasis.
- ItemIdentification of Statin’s Action in a Small Cohort of Patients with Major Depression(2021) Thakkar, Ishani; Massardo, Teresa; Pereira, Jaime; Quintana, Juan Carlos; Risco, Luis; Saez, Claudia G.; Corral, Sebastián; Villa, Carolina; Spuler, Jane; Olivares, Nixa; Valenzuela, Guillermo; Castro, Gabriel; Riedel, Byron; Vicentini, Daniel; Muñoz, Diego; Lastra, Raúl; Rodriguez-Fernandez, MariaStatins are widely used as an effective therapy for ischemic vascular disorders and employed for primary and secondary prevention in cardiac and cerebrovascular diseases. Their hemostatic mechanism has also been shown to induce changes in cerebral blood flow that may result in neurocognitive improvement in subjects with Major Depressive Disorder. Behavioral data, various blood tests, and resting-state brain perfusion data were obtained at the start of this study and three months post-therapy from a small cohort of participants diagnosed with Major Depressive Disorder. Subjects received either rosuvastatin (10 mg) or placebo with their standard selective serotonin reuptake inhibitors therapy. At the end of the study, patients using rosuvastatin reported more positive mood changes than placebo users. However, standard statistical tests revealed no significant differences in any non-behavioral variables before and after the study. In contrast, feature selection techniques allowed identifying a small set of variables that may be affected by statin use and contribute to mood improvement. Classification models built to assess the distinguishability between the two groups showed an accuracy higher than 85% using only five selected features: two peripheral platelet activation markers, perfusion abnormality in the left inferior temporal gyrus, Attention Switching Task Reaction latency, and serum phosphorus levels. Thus, using machine learning tools, we could identify factors that may be causing self-reported mood improvement in patients due to statin use, possibly suggesting a regulatory role of statins in the pathogenesis of clinical depression.
- ItemMobiCOP : A Scalable and Reliable Mobile Code Offloading Solution(2018) Benedetto Causa, José Ignacio; Valenzuela, Guillermo; Sanabria Quispe, Pablo; Neyem, Andrés; Navón Cohen, Jaime; Poellabauer, Christian
- ItemRethinking the Mobile Code Offloading Paradigm: From Concept to Practice(IEEE, 2017) Benedetto Causa, José Ignacio; Neyem, Andrés; Navón Cohen, Jaime; Valenzuela, GuillermoMobile code offloading is a relatively well known proposal for enhancing the capabilities of mobile platforms by migrating resource intensive tasks to resource rich surrogates hosted in the cloud. Yet, most of the research in the area has been focused on theoretical gains achieved through custom OS versions in ideal scenarios. This paper presents MobiCOP, a new code offloading platform that seeks to address the reproducibility issues of other offloading solutions by encapsulating all offloading logic in a library and offering compatibility with major IaaS providers. MobiCOP achieves comparable performance and battery improvements with gains of up to a factor of 11 in both areas. Moreover, MobiCOP has also been tested in scenarios with unreliable connectivity, as is usually the case in actual mobile networks, where it has shown that it still manages to outperform local task executions by a fair margin.