Browsing by Author "Uribe González, Pablo Francisco"

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    A case of gamasoidosis caused by Dermanyssus gallinae, misdiagnosed as delusional parasitosis
    (2018) Navarrete Dechent, Cristián Patricio; Uribe González, Pablo Francisco
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    Angiomatosis bacilar por Bartonella quintana como primera manifestación de infección por VIH
    (SOC MEDICA SANTIAGO, 2012) Uribe González, Pablo Francisco; Balcells Marty, María Elvira; Giesen Flaskamp, Laura; Cardenas De La Torre, Consuelo Paz; Garcia Muñoz, Patricia Alejandra; González Bombardiere, Sergio
    Bacillary angiomatosis is an unusual infectious disease, with angioproliferative lesions, typical of immunocompromised patients. It is caused by Bartonella quintana and Bartonella henselae, two infectious agents of the genus Bartonella, which trigger variable clinical manifestations, including cutaneous vascular and purpuric lesions, and regional lymphadenopathy, and even a systemic disease with visceral involvement. We report a 38-year-old HIV positive male presenting with a history of six months of cutaneous growing purple angiomatous lesions, located also in nasal fossae, rhinopharynx and larynx. The skin biopsy was compatible with bacillary angiomatosis. Polymerase chain reaction of a tissue sample showed homology with B. quintana strain Toulouse. The patient was treated with azithromycin and ciprofloxacin with a favorable evolution. (Rev Med Chile 2012; 140: 910-914).
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    Basal cell carcinomas presenting as flat pigmented macules on the face mimicking lentigo maligna on dermoscopy: a case series
    (2023) Navarrete-Dechent, Cristián; Uribe González, Pablo Francisco; Rabinovitz, Harold; Abarzúa Araya, Álvaro Rodrigo; Kittler, Herald
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    Biopsy type does not affect the number of stages during Mohs micrographic surgery: a retrospective study
    (Oxford University Press, 2023) Araneda Ortega, Paulina Belén; Donoso Mena, Francisca; Castro, Juan C.; Uribe González, Pablo Francisco; Rossi, Anthony M.; Hibler, Brian P.; Droppelmann Droppelmann, Katherine Ann; Cárdenas De La Torre, Consuelo Paz; Navarrete-Dechent, Cristian
    Mohs micrographic surgery (MMS) is the treatment of choice for high-risk basal cell carcinoma (BCC). However, there are no evidence-based recommendations regarding which biopsy type is more appropriate to obtain tumour samples prior to MMS. Shave or punch biopsies are performed depending on the clinical characteristics of the tumour, surgeon experience and local protocols. However, biopsy type might result in difficult histopathological interpretation and influence the practical implementation of MMS. We performed a retrospective study on 208 consecutive BCCs treated with MMS. Of the 208 BCC biopsies, 42 (20.2%) were obtained by the shave method and 166 (79.8%) via punch. Those obtained with the shave technique had a mean of 1.64 stages vs. 1.69 stages with the punch technique (P = 0.130). These findings suggest biopsy type does not affect Mohs surgery performance. The biopsy type of choice is the one deemed adequate for each specific case to obtain a diagnosis and tumour subtyping., In this study including 208 primary basal cell carcinomas undergoing Mohs micrographic surgery (MMS), there were no differences in the mean number of stages, regardless of which biopsy type was performed (shave vs. punch). The biopsy technique might affect correct subtype identification; however, there were also no differences in the rate of upstaging. Any tissue reaction could also result in difficult histopathological interpretation on frozen sections; however, this was not evident in our study. It seems that biopsy type, shave vs. punch, does not affect MMS performance; thus the more appropriate biopsy type is the one deemed adequate for each specific case in order to obtain a diagnosis as well as tumour subtyping.
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    Comparative analysis of loss of heterozygosity and microsatellite instability in adult and pediatric melanoma.
    (2005) Uribe González, Pablo Francisco; Wistuba, Ignacio I.; Solar, Antonieta; Balestrini, Claudia; Perez-Cotapos, Maria Luisa; Gonzalez, Sergio
    Although 0.3% of melanomas occur in children, the incidence has risen in past decades. In adult melanoma, some chromosomal regions in 1p, 6q, 9p, 10q, and 11q are frequently deleted. Microsatellite instability (MSI), which reflects impaired DNA repair, has been found at low levels in adult melanoma and melanocytic nevi. To investigate the molecular changes in pediatric melanoma, a screening for loss of heterozygosity and microsatellite instability was performed and compared with changes found in adult melanoma. Formalin-fixed, paraffin-embedded tissues from 10 adult melanomas, 9 melanocytic nevi, and 8 pediatric melanomas were microdissected and the DNA was extracted. Loss of heterozygosity and microsatellite instability were evaluated using 13 microsatellite repeat polymorphisms located in 1p36, 1q32, 2p12, 2p22-25, 2q33-37, 9p21, 10q23.3, 11q23, 13q14, 17p13, and 17q21. The overall frequency of loss of heterozygosity was 0.09 for nevi, 0.30 for adult melanoma, and 0.43 for pediatric melanoma (nevi vs. adult melanoma, P = 0.0082; nevi vs. pediatric melanoma, P = 0.0092). Pediatric melanoma has more loss of heterozygosity (44%) in 11q23 than adult melanoma (7%, P = 0.046). The microsatellite instability overall frequency was greater in pediatric melanoma (0.24) than nevi (0.05, P = 0.0031) and adult melanoma (0.09, P = 0.0195). Our findings suggest that pediatric melanoma has a different abnormal pattern than adult melanoma. Pediatric melanoma has more microsatellite instability than adult melanoma. 11q23 could contain genes related to the early age onset of melanoma. The high frequency of microsatellite instability is coincidental with the finding of higher levels of microsatellite instability in pediatric brain tumors and could play a role in the pathogenesis of pediatric melanoma.
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    Dermoscopy of linear basal cell carcinomas, a potential mimicker of linear lesions: a descriptive case series
    (2022) Navarrete-Dechent, Cristián; Marchetti, Michael; Uribe González, Pablo Francisco; Schwartz, Rodrigo; Liopyris, Konstantinos; Marghoob, Nadeem; Galimany Navajas, Lucas Fernando; Castro, Juan; Jaimes, Natalia; Rabinovitz, Harold; Moraes, Ana; Marghoob, Ashfaq; Abarzúa-Araya, Alvaro
    Introduction: Among the various widely recognized basal cell carcinoma (BCC) clinical patterns, linear basal cell carcinoma (LBCC) is an uncommon morphologic variant of BCC. Objectives: Describe the clinical and dermoscopic characteristics of LBCC. Methods: Retrospective study including LBCC cases from 5 dermatology centers in North and South America. Biopsy-proven primary BCCs, that presented with at least 3:1 length:width ratio on physical examination, irrespective of tumor subtype or location, were included. Clinical and dermoscopic analysis were performed by 2 experts in dermoscopy. Results: Eighteen cases of LBCC met our inclusion criteria and were included in the study. Median age at diagnosis was 86.0 years, 10 patients (58.8%) were males. Regarding anatomic location, 11/18.
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    Influence of socioeconomic status on clinical outcomes of malignant melanoma: a cross-sectional study in 746 patients
    (2016) Molgó Novell, Montserrat; Andino Navarrete, Romina; Navajas Galimany, Lucas; Silva, M. J.; Uribe González, Pablo Francisco; Sazunic, I.; Gonzalez, S.
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    Management of periocular keratinocyte carcinomas with Mohs micrographic surgery and predictors of complex reconstruction: a retrospective study
    (2023) Peirano, Dominga; Vargas Mancilla, Sebastián Enrique; Hidalgo Acuña, Leonel Esteban; Donoso Mendieta, Francisca; Abusleme, Eugenia; Sanhueza Zamora, Felipe Alberto; Cárdenas de la Torre, Consuelo Paz; Droppelmann, Katherine; Castro Ayala, Juan Camilo; Uribe González, Pablo Francisco; Zoroquiain Velez, José Pablo; Navarrete Dechent, Cristián Patricio
    Background: Skin cancer is the most frequent cancer worldwide and the most frequent periocular tumor. Keratinocyte Carcinomas (KC) located in periorificial areas, such as periocular tumors, are considered high-risk tumors. Mohs Micrographic Surgery (MMS) is considered the first line for the treatment of high-risk KC, providing a lower recurrence rate than conventional wide excision. Objective: To describe the clinical-pathological features of periocular KC treated with MMS in a tertiary university center in Chile. Methods: A single-center, retrospective study of patients with KC located on the periocular area, that underwent MMS between 2017---2022. MMS details were recorded. Results: One hundred thirteen patients with periocular carcinomas were included. The mean age was 59 ± 13 years; 52% were women. The most frequent location was the medial canthus (53%), followed by the lower eyelid (30.1%). The most frequent BCC histology was the nodular variant (59.3%). Regarding MMS, the average number of stages was 1.5 ± 0.7, and 54% of the cases required only 1 stage to achieve clear margins. To date, no recurrence has been reported. Tumors larger than 8.5 mm in largest diameter or 43.5 mm2were more likely to require complex reconstruction. Study limitations: Retrospective design and a relatively low number of patients in the SCC group. Possible selection bias, as larger or more complex cases, may have been referred to oculoplastic surgeons directly.
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    Marcadores cutáneos congénitos de patología del sistema nervioso central
    (1999) Pérez-Cotapos Subercaseaux, Maria Luisa; Uribe González, Pablo Francisco; Krämer, Daniela; García Bruce, Cristián Jorge
    Se revisan los principales marcadores cutáneos congénitos de patología del sistema nervioso central, tanto los de disrafias del tubo neural, como los marcadores cutáneos no asociados a este fenómeno. Es importante tener un alto índice de sospecha al evaluar neonatos y lactantes, dado que un diagnóstico precoz puede modificar el pronóstico neurológico, mejorando la calidad de vida de estos pacientes.
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    Reduction in the number of early melanomas diagnosed during the COVID‐19 pandemic: a single‐centre cohort study
    (2021) Koch Hein, Erica Cristina; Villanueva, Francisco; Marchetti, Michael A.; Abarzúa Araya, Álvaro Rodrigo; Cárdenas de la Torre, Consuelo Paz; Castro, Juan Camilo; Domínguez Covarrubias, Francisco José; Droppelmann, Katherine; Droppelmann, Nicolás; Galindo A., Héctor; León Ramírez, Augusto; Madrid Arenas, Jorge; Molgó Novell, Montserrat; Mondaca, Sebastián; Montero, Pablo H.; Uribe González, Pablo Francisco; Villaseca, Miguel A.; Vinés Vásquez, Eugenio; Navarrete Dechent, Cristian
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    Seborrhoeic dermatitis
    (2007) Manríquez Moreno, Juan; Uribe González, Pablo Francisco
    INTRODUCTION: Seborrhoeic dermatitis affects at least 1–3% of the population. Malassezia (Pityrosporum) ovale is thought to be the causative organism, and causes inflammation involving T cells and complement. Seborrhoeic dermatitis tends to relapse after treatment. METHODS AND OUTCOMES:We conducted a systematic review and aimed to answer the following clinical questions:What are the effects of topical treatments for seborrhoeic dermatitis of the scalp in adults? What are the effects of topical treatments for seborrhoeic dermatitis of the face and body in adults? We searched: Medline, Embase, The Cochrane Library and other important databases up to February 2006 (BMJ Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review).We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found nine systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: bifonazole, emollients, ketoconazole, lithium succinate, selenium sulphide, tar shampoo, terbinafine, and topical steroids (betamethasone valerate, clobetasol propionate, clobetasone butyrate, hydrocortisone, mometasone furate).
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    Symmetrical pruriginous nasal rash
    (2019) Navarrete Dechent, Cristián Patricio; Uribe González, Pablo Francisco
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    Ultraviolet-induced fluorescent dermoscopy for biopsy site identification prior to dermatologic surgery: a retrospective study
    (2023) Navarrete-Dechent, Cristián; Pietkiewicz, Pawel; Dusza, Stephen W.; Andreani, Sebastian; Nehal, Kishwer S.; Rossi, Anthony M.; Córdova, Miguel; H. Lee, Erica; Chih-Shan J. Chen; Abarzúa Araya, Álvaro Rodrigo; Uribe González, Pablo Francisco; Castro, Juan C.; Droppelmann, Katherine; Cárdenas de la Torre, Consuelo; Marghoob, Ashfaq A.