Browsing by Author "Torres, Gloria"

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    Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox
    (2008) Faúndez Cáceres, Mario; Lopez-Munoz, Rodrigo; Torres, Gloria; Morello, Antonio; Ferreira, Jorge; Kemmerling, Ulrike; Orellana, Myriam; Maya, Juan D.
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    Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole
    (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010) Lopez Munoz, Rodrigo; Faundez, Mario; Klein, Sebastian; Escanilla, Sebastian; Torres, Gloria; Lee Liu, Dasfne; Ferreira, Jorge; Kemmerling, Ulrike; Orellana, Myriam; Morello, Antonio; Ferreira, Arturo; Maya, Juan D.
    Nifurtimox and benznidazole are the only active drugs against Trypanosoma cruzi; however, they have limited efficacy and severe side effects. During primoinfection, T cruzi infected macrophages mount an antiparasitic response, which the parasite evades through an increase of tumor growth factor beta and PGE(2) activation as well as decreased iNOS activity. Thus, prostaglandin synthesis inhibition with aspirin might increase macrophage antiparasitic activity and increase nifurtimox and benznidazole effect.