Browsing by Author "Toledo, C."
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- ItemCarotid Body-Mediated Chemoreflex Drive in the Setting of low and High Output Heart Failure(2017) Del Río, R.; Andrade Andrade, David Cristóbal; Toledo, C.; Díaz, H.|Lucero, C.; Arce Álvarez, A.; Marcus, N.; Schultz, H.
- ItemExploring Intimate Partner Relationships before and after HIV Diagnosis among Minority Older Women(2021) Villegas, N.; Cianelli A., Rosina; De Oliveira, G.; Toledo, C.; Jacobson, F.; Davenport, E.; Webb, D.; Wolf, B.
- ItemHeart rate variability alterations in infants with spontaneous hypertonia(2019) Arce-Alvarez, A.; Melipillan, C.; Andrade Andrade, David Cristóbal; Toledo, C.; Marcus, N.J.; Del Rio, R.
- ItemKinematic and Neuromuscular Measures of Intensity During Plyometric Jumps(2017) Andrade Andrade, David Cristóbal; Manzo, O.; Beltran, A.; Álvarez, C.; Del Rio, R.; Toledo, C.; Moran, J.; Ramirez Campillo, R.
- ItemMotivation for Critical Thinking in Nursing Students in Chile(2020) Berger, K.; Cianelli A., Rosina; Valenzuela, J.; Villegas, N.; Blazquez, C.; Toledo, C.; Ramírez Barrantes, R.
- ItemNeurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment(SPRINGER, 2019) Toledo, C.; Andrade, D. C.; Diaz, H. S.; Inestrosa, N. C.; Del Rio, R.Heart failure (HF) is a major public health issue affecting more than 26 million people worldwide. HF is the most common cardiovascular disease in elder population; and it is associated with neurocognitive function decline, which represent underlying brain pathology diminishing learning and memory faculties. Both HF and neurocognitive impairment are associated with recurrent hospitalization episodes and increased mortality rate in older people, but particularly when they occur simultaneously. Overall, the published studies seem to confirm that HF patients display functional impairments relating to attention, memory, concentration, learning, and executive functioning compared with age-matched controls. However, little is known about the molecular mechanisms underpinning neurocognitive decline in HF. The present review round step recent evidence related to the possible molecular mechanism involved in the establishment of neurocognitive disorders during HF. We will make a special focus on cerebral ischemia, neuroinflammation and oxidative stress, Wnt signaling, and mitochondrial DNA alterations as possible mechanisms associated with cognitive decline in HF. Also, we provide an integrative mechanism linking pathophysiological hallmarks of altered cardiorespiratory control and the development of cognitive dysfunction in HF patients.