Browsing by Author "Silva, Francisco"

Now showing 1 - 9 of 9
  • Thumbnail Image
    Item
    A Multicenter Study To Evaluate Ceftaroline Breakpoints : Performance in an Area with High Prevalence of Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Lineage
    (2019) Khan, Ayesha; Rivas, Lina M.; Spencer, María; Martínez, Rodrigo; Lam, Marusella; Rojas, Pamela; Porte, Lorena; Silva, Francisco; Braun, Stephanie; García Cañete, Patricia; Valdivieso, Francisca; Mvlhauser, Margareta; Lafourcade, Mónica; Miller, William R.; Arias, César A.; Munita, José M.
  • Thumbnail Image
    Item
    A New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant S. aureus and E. faecium Infections
    (2018) Campanini Salinas, Javier; Andrades Lagos, Juan; González Rocha, Gerardo; Choquesillo Lazarte, Duane; Bollo Dragnic, Soledad; Faúndez Cáceres, Mario; Alarcón, Pedro; Silva, Francisco; Vidal, Roberto; Salas Huenuleo, Edison; Kogan Alterman, Marcelo; Mella, Jaime; Recabarren Gajardo, Gonzalo; Vásquez Velásquez, David
  • Thumbnail Image
    Item
    Compromiso renal en vasculitis asociadas a anticuerpos anticitoplasma de neutrófilos. Recomendaciones de consenso de las Sociedades Chilenas de Nefrología y Reumatología
    (2018) Aguirre, Verónica; Alvo, Miriam; Ardiles, Leopoldo; Fierro, Alberto; Goecke, Annelise; Iruretagoyena B., Mirentxu; Jalil Milad, Roberto; Massardo Vega, Loreto; Méndez Olivieri, Gonzalo Patricio; Palma, Sergio; Roessler, Emilio; Silva, Francisco; Wurgaft, Andrés
  • Thumbnail Image
    Item
    First isolation of kpc in Chile: from Italy to a public hospital in Santiago
    (SOC CHILENA INFECTOLOGIA, 2012) Cifuentes, Marcela; Garcia, Patricia; San Martin, Paola; Silva, Francisco; Zuniga, Jennifer; Reyes, Sergio; Rojas, Rodrigo; Ponce, Rodrigo; Quintanilla, Raul; Delpiano, Luis; Wolff, Marcelo
    Carbapenem resistance in Enterobacteriaceae is an emerging problem worldwide. Among the mechanisms involved are the production of ESBLs or AmpC associated with porins loss or the presence of carbapenemases. Among these, the KPC betalactamase has become especially relevant given its rapid spread.In this article we present the first case of isolation of a strain of KPC producer Klebsiella pneumoniae at a hospital in Santiago, in a patient coming from Italy, with a history of multiple hospitalizations for treatment of non-Hodgkin lymphoma and subjected to several cycles of chemotherapy and hemodialysis. The strain was isolated from a urine culture on the seventh day of the patient's arrival to Chile. The isolate was resistant to quinolones, aminoglycosides, cephalosporins and carbapenems, retaining only susceptibility to tigecycline and colistin. In phenotypic test it was found to have positive Hodge test and positive synergy with carbapenems/boronic acid. Polymerase chain reaction demonstrated the presence of beta-lactamases TEM, SHV and KPC-2. None other Class A serine-carbapenemase or metallo-bectalactamases were present.
  • Thumbnail Image
    Item
    Grupo Colaborativo de Resistencia Bacteriana, Chile : recomendaciones 2014 para el control de la resistencia bacteriana
    (2015) Cifuentes, Marcela; Silva, Francisco; Arancibia, J. Miguel; Rosales, Ruth; Ajenjo Henríquez, María Cristina; Riedel, Gisela; Camponovo, Rossana; Labarca L., Jaime
  • Thumbnail Image
    Item
    Incidencia de bacterias multi-resistentes en unidades de cuidados intensivos de hospitales chilenos
    (2017) Paz Acuna, M.; Cifuentes, Marcela; Silva, Francisco; Rojas, Alvaro; Cerda, Jaime; Labarca, Jaime; Grp Colaborativo Resistencia
    Introduction: Incidence of multi-resistant bacteria is an indicator that permits better estimation of the magnitude of bacterial resistance in hospitals. Aim: To evaluate the incidence of relevant multi-drug resistant bacteria in intensive care units (ICUs) of Chile. Methods: Participating hospitals submitted information about the number of isolates from infected or colonized patients with 7 epidemiologically relevant multi-resistant bacteria in adult and pediatric ICUs between January 1, 2014 and October 31, 2015 and the number of bed days occupied in these units in the same period was requested. With these data incidence was calculated per 1,000 patient days for each unit. Results: Information from 20 adults and 9 pediatric ICUs was reviewed. In adult ICUs the bacteria with the highest incidence were K. pneumoniae ESBL [4.72 x 1,000 patient day (1.21-13.89)] and oxacillin-resistant S. aureus [3.85 (0.71-12.66)]. In the pediatric units the incidence was lower, highlighting K. pneumoniae ESBL [2.71 (0-7.11)] and carbapenem-resistant P aeruginosa [1.61 (0.31-9.25)]. Conclusion: Important differences between hospitals in the incidence of these bacteria were observed. Incidence of multi-resistant bacteria in adult ICU was significantly higher than in pediatric ICU for most of the studied bacterias.
  • Thumbnail Image
    Item
    Solid Malignancies Among Etanercept-Treated Patients With Granulomatosis With Polyangiitis (Wegener's) Long-Term Followup of a Multicenter Longitudinal Cohort
    (WILEY, 2011) Silva, Francisco; Seo, Philip; Schroeder, Darrell R.; Stone, John H.; Merkel, Peter A.; Hoffman, Gary S.; Spiera, Robert; Sebastian, Jodi K.; Davis, John C., Jr.; St Clair, E. William; Allen, Nancy B.; McCune, W. Joseph; Ytterberg, Steven R.; Specks, Ulrich; Wegener's Granulomatosis
    Objective. An association between therapeutic inhibition of tumor necrosis factor (TNF) and solid malignancies was observed during the Wegener's Granulomatosis Etanercept Trial (WGET), which included 180 patients with granulomatosis with polyangiitis (Wegener's) (GPA). The present study was conducted to determine the malignancy risk beyond the time of exposure to study therapy.
  • Thumbnail Image
    Item
    Susceptibilidad antimicrobiana en Chile 2012
    (2014) Cifuentes D., Marcela; Silva, Francisco; García Cañete, Patricia; Bello, Helia; Briceño, Isabel; Calvo A., Mario; Labarca L., Jaime
  • Thumbnail Image
    Item
    TNF-alpha Blocker Therapy and Solid Malignancy Risk in ANCA-Associated Vasculitis
    (SPRINGER, 2012) Silva, Francisco; Cisternas, Marcela; Specks, Ulrich
    ANCA-associated vasculitides (AAV) are small vessel systemic vasculitis syndromes associated with the potential for high morbidity and mortality. This group includes granulomatosis with polyangiitis (Wegener's, GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (Churg-Strauss, EGPA). The standard treatment consists of a combination of glucocorticoids and potent immunosuppressant drugs. These have broad mechanisms of action as well as important adverse effects. Efforts have been made to investigate novel agents with better-defined and narrower mechanisms of action, such as biologics, including TNF-alpha blockers. Etanercept, a well-known TNF-alpha blocker evaluated for GPA in the Wegener's Granulomatosis Etanercept Trial (WGET), was associated with an increase in the development of solid malignancies in comparison to placebo during that trial period. A 5-year follow-up after the WGET trial showed a sustained increase in incidence of solid malignancies, but this could no longer be solely attributed to etanercept exposure. These studies raised concerns about the use of the family of TNF-alpha blockers in AAV. Here, we review the evidence about the association between therapeutic inhibition of tumor necrosis factor (TNF-alpha) by etanercept and other TNF-alpha blockers with the development of solid malignancies in GPA and other AAV.