Browsing by Author "Serrano Honeyman, Carolina Andrea"

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    Antimicrobial Resistance of Helicobacter pylori Isolated From Latin American Children and Adolescents (2008–2023): A Systematic Review
    (2024) Cabrera, Camila; Torres, Joaquín; Serrano Honeyman, Carolina Andrea; Gallardo, Paulina; Orellana, Vicente; George, Sergio; O'Ryan, Miguel; Lucero, Yalda
    Background: Latin America has a high prevalence of Helicobacter pylori in children that may lead to peptic ulcer disease andeventually gastric cancer in adulthood. Successful eradication is hindered by rising antimicrobial resistance. We summarize H.pylori resistance rates in Latin American children from 2008 to 2023.Material and Methods: Systematic review following PRISMA guidelines and National Heart, Lung, and Blood Institute check-list to assess risk of bias (PROSPERO CRD42024517108) that included original cross-sectional observational studies reportingresistance to commonly used antibiotics in Latin American children and adolescents. We searched in PubMed, LILACS, andSciELO databases.Results: Of 51 studies, 45 were excluded. The quality of the six analyzed studies (297 H. pylori-positive samples) was satisfactory.Phenotypic methods (N = 3) reported higher resistance rates than genotypic studies (N = 3). Clarithromycin resistance rangedfrom 8.0% to 26.7% (6 studies; 297 samples), metronidazole from 1.9% to 40.2% (4 studies; 211 samples), amoxicillin from 0% to10.4% (3 studies; 158 samples), tetracycline resistance was not detected (3 studies; 158 samples), and levofloxacin resistance was2.8% (1 study; 36 samples).Conclusion: Scarce Latin American studies on H. pylori resistance, along with methodological heterogeneity, hinder conclusivefindings. Clarithromycin and metronidazole (first-line drugs) resistance is worrisome, likely impacting lower eradication rates.Urgent systematic surveillance or individual testing before treatment is necessary to enhance eradication.
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    Attenuated Salmonella typhimurium encoding the HpaA antigen of Helicobacter pylori elicit a Th1 and Th2 immune response
    (2007) Serrano Honeyman, Carolina Andrea; Olmos, Marco; Bruce, Elsa; Martinez, Patricio; Torres, Javiera; Venegas, Alejandro; Harris Diez, Paul Richard
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    Different Strains of H. pylori Induce Tolerogenic Dendritic Cells in Children
    (2015) Serrano Honeyman, Carolina Andrea; Brawner, Kyle; Vera Cabezas, Macarena Alejandra; Hernández Vargas, Caroll Daffner; Villagran Torres, Andrea Alejandra; Smythies, Lesley E.; Smith, Phillip D.; Harris Diez Paul Richard
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    Food allergy markers in peptic disease
    (2009) Talesnik Guendelman, Eduardo; Majerson Grinberg, Daniela; Serrano Honeyman, Carolina Andrea; Einisman Fleiderman, Helly Jael; Aravena González, Carmen Fabiola; Peña Villegas, Alfredo Javier; Ros Torres, Javiera Ignacia; Duarte Garcia, De Cortázar Ignacio; Harris Diez, Paul Richard
    Background: The double-blind food challenge is the gold standard for diagnosis of food allergy, eventhough it is difficult to standardize and execute. An increase in allergy prevalence worldwide accentuates the importance of evaluating food allergy markers, in order to help the diagnosis. Objective: Elaboration of an operational definition for food hypersensitivity (FH) and evaluate the role of allergy markers, endoscopic and hystological findings, gastric mucosa cytokines and personal/family history of allergy in children. Method: Enrollment of children with suspected peptic disease referred for endoscopy. We obtained antral biopsies for hystological evaluation (eosinophil and mast cell count) and measurement of mucosal cytokines through an ELISA test. Patients were evaluated with Prick test, total serum IgE and clinical questionnaires for allergies. They were divided into two groups; children with and without food hypersensitivity. Results: 97 children were enrolled (mean: 11.7 ± 3, range 3-18). 4% of children had FH. The endoscopic findings did not correlate with the presence of FH. 74.1% of patients without FH had eosinophils in the gastric mucosa compared to groups with FH which had 100% (p < 0.05). Only IL-2 among the evaluated cytokines was found in a greater concentration in patients without FH. 33% of patients considered themselves having history of personal allergies versus 11.8% of people without FH (p < 0.05). Conclusions: 12,4% of children with digestive symptoms referred to endoscopy have FH. There are no clinical, endoscopic or hystological differences between patients with or without FH.
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    Helicobacter pylori Displays Differential Iron Regulated Gene Expression Depending on Iron Status of Their Host
    (2012) Serrano Honeyman, Carolina Andrea; Villagran Torres, Andrea Alejandra; Cofre Dougnac, Colomba Del Carmen; Álvarez Espinoza, Manuel Alejandro; Venegas, Alejandro; Toledo, Hector; Harris Diez, Paul Richard
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    Helicobacter pylori infection in children is associated with a mucosal T regulatory cell response and less severe gastritis than that of adults
    (2007) Wright, Shelton W.; Smythies, Lesley; Riera Cassorla, Francisca Paz; Espinoza Torres, Javiera Marcela; Novak, Lea; Schmitz, Julia; Lorenz, Robin G.; Serrano Honeyman, Carolina Andrea; Harris Diez, Paul Richard; Smith, Phillip D.
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    Interactions between H. pylori and the gastric microbiome: impact on gastric homeostasis and disease
    (ELSEVIER, 2021) Serrano Honeyman, Carolina Andrea; Harris Diez, Paul Richard; Smith, Phillip D.; Bimczok, Diane
    Like many seemingly inhospitable environments on our planet, the highly acidic human stomach harbors a diverse bacterial microflora. The best-known member of the human gastric flora, Helicobacter pylori, causes a number of gastric diseases, including peptic ulcer disease and gastric adenocarcinoma. In the absence of H. pylori infection, the gastric microbiota displays some features similar to the oral cavity with Firmicutes the most common phylum, followed by Proteobacteria and Bacteroidetes. When present, H. pylori dominates the gastric microbiome and reduces diversity and composition of other taxa. The composition of the gastric microbiome also is altered in the setting of proton pump inhibitor therapy and gastric neoplasia. This review summarizes foundational and recent studies that have investigated the composition of the human gastric microbiome in a variety of patient groups, with a focus on potential mechanisms involved in regulation of gastric microbial community structure.
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    Interleukin-1 beta and Tumor Necrosis Factor-alpha Polymorphisms as Iron Deficiency Risk Markers in Helicobacter pylori-Infected Children
    (2012) Serrano Honeyman, Carolina Andrea; Villagrán Torres, Andrea Alejandra; Venegas, Alejandro; Toledo, Hector; Crabtree, Jean E.; Harris Diez, Paul Richard
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    Letter: childhood recurrent abdominal pain is associated with increased duodenal eosinophilia independent of Helicobacter pylori infection
    (WILEY, 2023) Wauters, Lucas; Harris Diez, Paul Richard; Walker, Marjorie M.; Serrano Honeyman, Carolina Andrea; Villagrán Torres, Andrea Alejandra; Rakhra, Gurpreet S.; Crabtree, Jean E.; Talley, Nicholas J.
    LINKED CONTENT This article is linked to Broeders et al paper. To view this article, visit
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    Utilidad del Diagnostico Serologico de la Infeccion por Helicobacter Pylori en Niños
    (2005) Harris Diez, Paul Richard; González Fuentes, Carmen Gloria; Serrano Honeyman, Carolina Andrea
    Helicobacter pylori (H. pylori) afecta al 50% de la población mundial. La infección se adquiere en la infancia; siendo justamente el grupo pediátrico en el cual impera la necesidad de validar métodos diagnósticos no invasivos que permitan diagnosticar la infección. El objetivo de este trabajo fue revisar la literatura sobre el diagnóstico serológico de la infección por H. pylori, con especial énfasis en población pediátrica. La mayor utilidad de la serología ha sido en estudios epidemiológicos, al permitir conocer la prevalencia de la infección. En pacientes adultos esta técnica presenta valores de sensibilidad y especificidad superiores al 90% y es comparable a métodos diagnósticos invasivos; la situación cambia en población pediátrica, sobre todo en el grupo de niños pequeños donde la serología pierde mucho de su sensibilidad y especificidad, lo cual restringe el uso de la serología para propósitos clínicos en población infantil.