Browsing by Author "Serrano, Felipe G."
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- ItemAnti-Ribosomal P Protein Autoantibodies From Patients With Neuropsychiatric Lupus Impair Memory in Mice(2015) Bravo Zehnder, Marcela; Toledo, Enrique M.; Segovia Miranda, Fabian; Serrano, Felipe G.; Benito, Maria J.; Metz Baer, Claudia Andrea; Retamal, Claudio; Álvarez Rojas, Alejandra; Massardo Vega, Loreto; Inestrosa Cantín, Nibaldo
- ItemFructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance(2015) Cisternas, Pedro; Salazar, Paulina; Serrano, Felipe G.; Montecinos Oliva, Carla; Arredondo, Sebastián B.; Varela Nallar, Lorena Patricia; Barja Y., Salesa; Vio Lagos, Carlos P.; Gomez Pinilla, Fernando; Inestrosa Cantín, Nibaldo
- ItemRhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in A beta PPswe/PS-1 Mice of Different Ages(2016) Serrano, Felipe G.; Tapia Rojas, Cheril Cecilia; Carvajal Cachaña, Francisco Javier; Cisternas, Pedro; Viayna, Elisabet; Sola, Irene; Muñoz Torrero, Diego; Inestrosa Cantín, Nibaldo
- ItemThe increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's disease(2015) Cisternas, Pedro; Lindsay, Carolina B.; Salazar, Paulina; Silva Álvarez, Carmen; Retamales, Rocio M.; Serrano, Felipe G.; Vio Lagos, Carlos P.; Inestrosa Cantín, Nibaldo
- ItemWingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses(NATL ACAD SCIENCES, 2010) Varela Nallar, Lorena; Alfaro, Ivan E.; Serrano, Felipe G.; Parodi, Jorge; Inestrosa, Nibaldo C.Growing evidence indicates that Wingless-type (Wnt) signaling plays an important role in the maturation of the central nervous system. We report here that Wingless-type family member 5A (Wnt-5a) is expressed early in development and stimulates dendrite spine morphogenesis, inducing de novo formation of spines and increasing the size of the preexisting ones in hippocampal neurons. Wnt-5a increased intracellular calcium concentration in dendritic processes and the amplitude of NMDA spontaneous miniature currents. Acute application of Wnt-5a increased the amplitude of field excitatory postsynaptic potentials (fEPSP) in hippocampal slices, an effect that was prevented by calcium-channel blockers. The physiological relevance of our findings is supported by studies showing that Wnt scavengers decreased spine density, miniature excitatory postsynaptic currents, and fEPSP amplitude. We conclude that Wnt-5a stimulates different aspects of synaptic differentiation and plasticity in the mammalian central nervous system.
- ItemWnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production(2015) Parodi, Jorge; Montecinos Oliva, Carla; Varas, Rodrigo; Alfaro, Iván E.; Serrano, Felipe G.; Varas Godoy, Manuel; Muñoz, Francisco J.; Cerpa Nebott, Waldo Francisco; Godoy, Juan A.; Inestrosa Cantín, Nibaldo