Browsing by Author "Salinas, Francisco"
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- ItemFungal light-oxygen-voltage domains for optogenetic control of gene expression and flocculation in yeast(2018) Salinas, Francisco; Rojas Jorquera, Vicente Alberto; Delgado Hernández, Verónica Melissa; López Salinas, Javiera C.; Agosin T., Eduardo; Larrondo Castro, Luis Fernando
- ItemIndirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains(2019) Kessi‐Pérez, Eduardo I.; Salinas, Francisco; Molinet, Jennifer; González, Asier; Muñiz, Sara; Guillamón, José M.; Hall, Michael N.; Larrondo Castro, Luis Fernando; Martínez, Claudio
- ItemNatural Variation in Non-coding Regions Underlying Phenotypic Diversity in Budding Yeast(2016) Salinas, Francisco; De Boer, Carl G.; Abarca, Valentina; García, Verónica; Cuevas, Mara; Araos, Sebastian; Larrondo Castro, Luis Fernando; Martínez, Claudio; Cubillos, Francisco A.
- ItemPowerful decomposition of complex traits in a diploid model(NATURE PUBLISHING GROUP, 2016) Hallin, Johan; Maertens, Kaspar; Young, Alexander I.; Zackrisson, Martin; Salinas, Francisco; Parts, Leopold; Warringer, Jonas; Liti, GianniExplaining trait differences between individuals is a core and challenging aim of life sciences. Here, we introduce a powerful framework for complete decomposition of trait variation into its underlying genetic causes in diploid model organisms. We sequence and systematically pair the recombinant gametes of two intercrossed natural genomes into an array of diploid hybrids with fully assembled and phased genomes, termed Phased Outbred Lines (POLs). We demonstrate the capacity of this approach by partitioning fitness traits of 6,642 Saccharomyces cerevisiae POLs across many environments, achieving near complete trait heritability and precisely estimating additive (73%), dominance (10%), second (7%) and third (1.7%) order epistasis components. We map quantitative trait loci (QTLs) and find nonadditive QTLs to outnumber (3:1) additive loci, dominant contributions to heterosis to outnumber overdominant, and extensive pleiotropy. The POL framework offers the most complete decomposition of diploid traits to date and can be adapted to most model organisms.
- ItemRIM15 antagonistic pleiotropy is responsible for differences in fermentation and stress response kinetics in budding yeast(2016) Kessi Pérez, Eduardo I.; Araos, Sebastián; García, Verónica; Salinas, Francisco; Abarca, Valentina; Larrondo Castro, Luis Fernando; Martínez, Claudio; Cubillos, Francisco A.