Browsing by Author "Salas Villarroel, Patricio"

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Extracorporeal membrane oxygenation for tuberculosis-related acute respiratory distress syndrome: An international multicentre retrospective cohort study
    (2024) Ait Hssain, Ali; Petit, Matthieu; Wiest, Clemens; Simon, Laura; Al-Fares, Abdulrahman A.; Hany, Ahmed; Garcia-Gomez, Dafna I.; Besa, Santiago; Nseir, Saad; Guervilly, Christophe; Alqassem, Wael; Lesouhaitier, Mathieu; Chelaru, Adrian; Sin, Simon W.; Roncon-Albuquerque, Roberto; Giani, Marco; Lepper, Philipp M.; Lavillegrand, Jean-Rémi; Park, Sunghoon; Schellongowski, Peter; Fawzy Hassan, Ibrahim; Combes, Alain; Sonneville, Romain; Schmidt, Matthieu; Salas Villarroel, Patricio; Bravo Morales, Sebastián
    Abstract Objective To report the outcomes of patients with severe tuberculosis (TB)-related acute respiratory distress syndrome (ARDS) on extracorporeal membrane oxygenation (ECMO), including predictors of 90-day mortality and associated complications. Methods An international multicenter retrospective study was conducted in 20 ECMO centers across 13 countries between 2002 and 2022. Results We collected demographic data, clinical details, ECMO-related complications, and 90-day survival status for 79 patients (median APACHE II score of 20 [25th to 75th percentile, 16 to 28], median age 39 [28 to 48] years, PaO2/FiO2 ratio of 69 [55 to 82] mmHg before ECMO) who met the inclusion criteria. Thoracic computed tomography showed that 61 patients (77%) had cavitary TB, while 18 patients (23%) had miliary TB. ECMO-related complications included major bleeding (23%), ventilator-associated pneumonia (41%), and bloodstream infections (32%). The overall 90-day survival rate was 51%, with a median ECMO duration of 20 days [10 to 34] and a median ICU stay of 42 days [24 to 65]. Among patients on VV ECMO, those with miliary TB had a higher 90-day survival rate than those with cavitary TB (90-day survival rates of 81% vs. 46%, respectively; log-rank P = 0.02). Multivariable analyses identified older age, drug-resistant TB, and pre-ECMO SOFA scores as independent predictors of 90-day mortality. Conclusion The use of ECMO for TB-related ARDS appears to be justifiable. Patients with miliary TB have a much better prognosis compared to those with cavitary TB on VV ECMO.
  • No Thumbnail Available
    Item
    Lobectomía video-asistida por puerto único utilizando un nuevo modelo de simulación ex vivo perfundido
    (2016) Ávila Sepúlveda, Rubén; Achurra Tirado, Pablo; Tejos, Rodrigo; Varas Cohen, Julián; Solovera Rozas, María; Salas Villarroel, Patricio; Pontificia Universidad Católica de Chile. Escuela de Medicina
    La simulación puede proporcionar una solución para adquirir habilidades avanzadas en cirugía torácica, sin embargo, hasta la fecha de publicación de este artículo no hay informes sobre un modelo ex vivo perfundido. Desarrollamos un modelo de bajo costo y alta fidelidad utilizando una muestra ex vivo en bloque de corazón y pulmón de un cerdo. El cerdo se usó previamente en un experimento no torácico, por lo que extrajimos el pulmón y el corazón para este modelo basado ex-vivo para reducir el uso de animales. El costo del modelo completo es de 70 USD y se puede reutilizar muchas veces cambiando el tejido ex vivo, por lo que este modelo puede ayudar a reducir los costos y el uso de animales asociados a esta cirugía de alta complejidad.
  • Thumbnail Image
    Item
    Tumor fibroso solitario de la pleura asociado a síndromes paraneoplásicos
    (2013) León, F.; Bannura Yazigi, Felipe Alfonso; Solovera Rozas, María; Salas Villarroel, Patricio