Browsing by Author "Rothhammer, F."
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- ItemAttention-deficit hyperactivity disorder involves differential cortical processing in a visual spatial attention paradigm(ELSEVIER IRELAND LTD, 2006) Lopez, V.; Lopez Calderon, J.; Ortega, R.; Kreither, J.; Carrasco, X.; Rothhammer, P.; Rothhammer, F.; Rosas, R.; Aboitiz, F.Objective: Inattention is undoubtedly one of the main characteristics of Attention-deficit hyperactivity disorder (ADHD). Nevertheless, a growing corpus of evidence shows that not all attentional processes are affected in this condition. This study aimed to explore the distribution of attentional resources in children with ADHD via a spatially shifted double-oddball visual task.
- ItemDéficit atencional con hiperactividad: trastorno multicausal de la conducta, con heredabilidad y comorbilidad genética moderadas(2017) Puddu, G.; Rothhammer, P.; Carrasco, X.; Aboitiz, Francisco; Rothhammer, F.
- ItemIntra-individual response variability assessed by ex-Gaussian analysis may be a new endophenotype for attention-deficit/hyperactivity disorder(2015) Henriquez-Henriquez, M. P.; Billeke, P.; Henriquez, H.; Zamorano, F. J.; Rothhammer, F.; Aboitiz, FranciscoIntra-individual variability of response times (RTisv) is considered as potential endophenotype for attentional deficit/hyperactivity disorder (ADHD). Traditional methods for estimating RTisv lose information regarding response times (RTs) distribution along the task, with eventual effects on statistical power. Ex-Gaussian analysis captures the dynamic nature of RTisv, estimating normal and exponential components for RT distribution, with specific phenomenological correlates. Here, we applied ex-Gaussian analysis to explore whether intra-individual variability of RTs agrees with criteria proposed by Gottesman and Gould for endophenotypes. Specifically, we evaluated if normal and/or exponential components of RTs may (a) present the stair-like distribution expected for endophenotypes (ADHD > siblings > typically developing children (TD) without familiar history of ADHD) and (b) represent a phenotypic correlate for previously described genetic risk variants. This is a pilot study including 55 subjects (20 ADHD-discordant sibling-pairs and 15 TD children), all aged between 8 and 13 years. Participants resolved a visual Go/Nogo with 10% Nogo probability. Ex-Gaussian distributions were fitted to individual RT data and compared among the three samples. In order to test whether intra-individual variability may represent a correlate for previously described genetic risk variants, VNTRs at DRD4 and SLC6A3 were identified in all sibling-pairs following standard protocols. Groups were compared adjusting independent general linear models for the exponential and normal components from the ex-Gaussian analysis. Identified trends were confirmed by the non-parametric Jonckheere–Terpstra test. Stair-like distributions were observed for μ (p = 0.036) and σ (p = 0.009). An additional “DRD4-genotype” × “clinical status” interaction was present for τ (p = 0.014) reflecting a possible severity factor. Thus, normal and exponential RTisv components are suitable as ADHD endophenotypes.
- ItemSpecific Gram-Positive antibacterial activity of 4-(hydroxy-3-(3-methyl-2-butenyl) acetophenone isolated from senecio graveolens(2014) Santander T., Jaime A.; Otto, C.; Lowry, D.; Cuellar, M.; Mellado, M.; Salas Sánchez, Cristián Osvaldo; Rothhammer, F.; Echiburu-Chau, C.
- ItemThe selective cytotoxicity elicited by phytochemical extract from Senecio graveolens ( Asteraceae) on breast cancer cells is enhanced by hypoxia(2014) Echiburu-Chau, C.; Alfaro Lira, S.; Brown, N.; Salas Sánchez, Cristián Osvaldo; Cuellar, M.; Santander T., Jaime A.; Ogalde, J.; Rothhammer, F.