Browsing by Author "Rodríguez Martínez, Carlos E."
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- ItemCost-effectiveness of the utilization of "good practice" or the lack thereof according to a bronchiolitis evidence-based clinical practice guideline(2019) Rodríguez Martínez, Carlos E.; Sossa Briceño, Mónica P.; Castro Rodríguez, José AntonioRationale, aims, and objectives: The aim of the present study was to determine the cost-effectiveness of the utilization of “good practice” according to a bronchiolitis clinical practice guideline (CPG) in a population of infants hospitalized for acute bronchiolitis. Method: A decision-analysis model was developed in order to estimate the cost-effectiveness of the utilization of “good practice” compared with the lack of use of “good practice” according to a bronchiolitis evidence-based CPG. The effectiveness parameters and costs of the model were obtained from electronic medical records. The main outcome was the readmission of the patients within 10 days of post discharge. Results: Compared with lack of “good practice,” the utilization of “good practice” in the diagnosis and management of patients with bronchiolitis was associated with both fewer patients readmitted within 10 days of post discharge (0.88 vs 0.99 on average per patient) and lower costs (US$1529.3 versus $1709.1 average cost per patient), thus leading to dominance. Results were robust to deterministic and probabilistic sensitivity analyses. Conclusions: Compared with lack of “good practice,” the utilization of “good practice” in the diagnosis and management of acute bronchiolitis according to a bronchiolitis CPG is a dominant strategy because it involves both fewer patients readmitted within 10 days of post discharge and lower costs.
- ItemCost-utility analysis of once-daily versus twice-daily inhaled corticosteroid dosing for maintenance treatment of asthma in pediatric patients(2016) Rodríguez Martínez, Carlos E.; Sossa Briceño, Mónica, P.; Castro Rodríguez, José Antonio
- ItemCost-Utility Analysis of the Inhaled Steroids Available in a Developing Country for the Management of Pediatric Patients with Persistent Asthma(2013) Rodríguez Martínez, Carlos E.; Sossa Briceño, Mónica P.; Castro Rodríguez, José Antonio
- ItemDaily inhaled corticosteroids or montelukast for preschoolers with asthma or recurrent wheezing : A systematic review(2018) Castro Rodríguez, José Antonio; Rodríguez Martínez, Carlos E.; Ducharme, Francine M.
- ItemDexamethasone or prednisolone for asthma exacerbations in children: A cost-effectiveness analysis(2020) Rodríguez Martínez, Carlos E.; Sossa Briceño, Mónica P.; Castro Rodríguez, José Antonio
- ItemFactors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature(2017) Rodríguez Martínez, Carlos E.; Sossa Briceño, Monica P.; Castro Rodríguez, José AntonioBackground: For the early identification of persistent asthma symptoms among young children with recurrent wheezing, it would be helpful to identify all available studies that have identified at least one factor for predicting the persistence of early wheezing. The objective of the present study was to perform a systematic review of all studies that have identified factors that predict the persistence of symptoms among young patients with recurring wheezing. Methods: A systematic review of relevant studies was conducted through searching in MEDLINE, EMBASE, CINHAL, and SCOPUS databases up to June 2016. Studies that identified predictors of persistence of wheezing illness among young children with recurrent wheezing were retrieved. Two independent reviewers screened the literature and extracted relevant data. Results: The literature search returned 649 references, 619 of which were excluded due to their irrelevance. Five additional studies were identified from reference lists, and 35 studies were finally included in the review. Among all the identified predictors, the most frequently identified ones were the following: family asthma or atopy; personal history of atopic diseases; allergic sensitization early in life; and frequency, clinical pattern, or severity of wheezing/symptoms. Conclusion: Parental asthma (especially maternal), parental allergy, eczema, allergic rhinitis, persistent wheezing, wheeze without colds, exercise-induced wheeze, severe wheezing episodes, allergic sensitization (especially polysensitization), eosinophils (blood or eosinophil cationic protein in nasal sample), and fraction of exhaled nitric oxide were risk factors predicting persistence of early wheezing through school age. All of them are included in conventional algorithms, for example, Asthma Predictive Index and its modifications, for predicting future asthma.
- ItemFor which infants with viral bronchiolitis could it be deemed appropriate to use albuterol, at least on a therapeutic trial basis?(2021) Rodríguez Martínez, Carlos E.; Nino, Gustavo; Castro-Rodriguez, José A.; Acuña-Cordero, Ranniery; Sossa-Briceño, Mónica P.; Midulla, FabioAlthough there is increasing evidence showing that infants with viral bronchiolitis exhibit a high degree of heterogeneity, a core uncertainty shared by many clinicians is with regard to understanding which patients are most likely to benefit from bronchodilators such as albuterol. Based on our review, we concluded that older infants with rhinovirus (RV) bronchiolitis, especially those with a nasopharyngeal microbiome dominated by Haemophilus influenzae; those affected during nonpeak months or during non-respiratory syncytial virus (RSV) predominant months; those with wheezing at presentation; those with clinical characteristics such as atopic dermatitis or a family history of asthma in a first-degree relative; and those infants infected with RSV genotypes ON1 and BA, have the greatest likelihood of benefiting from albuterol. Presently, this patient profile could serve as the basis for rational albuterol administration in patients with viral bronchiolitis, at least on a therapeutic trial basis, and it could also be the starting point for future targeted randomized clinical trials (RCTs) on the use of albuterol among a subset of infants with bronchiolitis.
- ItemLeukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children(2015) Brodlie, Malcolm; Gupta, Atul; Rodríguez Martínez, Carlos E.; Castro Rodríguez, José Antonio; Ducharme, Francine M.; Mckean, Michel C.; Brodlie, Malcolm; Gupta, Atul; Rodríguez Martínez, Carlos E.; Castro Rodríguez, José Antonio; Ducharme, Francine M.; Mckean, Michel C.; Brodlie, Malcolm; Gupta, Atul; Rodríguez Martínez, Carlos E.; Castro Rodríguez, José Antonio; Ducharme, Francine M.; Mckean, Michel C.; Brodlie, Malcolm; Gupta, Atul; Rodríguez Martínez, Carlos E.; Castro Rodríguez, José Antonio; Ducharme, Francine M.; Mckean, Michel C.
- ItemPrincipal findings of systematic reviews for chronic treatment in childhood asthma(2015) Castro Rodríguez, José Antonio; Rodrigo, Gustavo J.; Rodríguez Martínez, Carlos E.
- ItemPrincipal findings of systematic reviews for the management of acute bronchiolitis in children(2015) Castro Rodríguez, José Antonio; Rodríguez Martínez, Carlos E.; Sossa Briceño, Mónica P.
- ItemPrincipal findings of systematic reviews of acute asthma treatment in childhood(2015) Castro Rodríguez, José Antonio; Rodrigo, Gustavo J.; Rodríguez Martínez, Carlos E.