DSpace Angular :: Browsing by Author "Riquelme, Ismael"

Browsing by Author "Riquelme, Ismael"

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Assessment of Gastritis and Gastric Cancer Risk in the Chilean Population Using the OLGA System
(2019) Bellolio, Enrique; Riquelme, Ismael; Riffo Campos, Angela L.; Rueda, Carlos; Ferreccio Readi, Catterina; Villaseca, Miguel; Brebi, Priscilla; Muñoz, Sergio R.; Araya, Juan Carlos
Correction to : MicroRNA‑335‑5p is a potential suppressor of metastasis and invasion in gastric cancer
(2021) Sandoval Bórquez, Alejandra; Polakovicova, Iva; Carrasco Véliz, Nicolás; Lobos González, Lorena; Riquelme, Ismael; Carrasco Avino, Gonzalo; Bizama, Carolina; Norero Muñoz, Enrique; Owen, Gareth Ivor; Roa Strauch, Juan Carlos Enrique; Corvalán R., Alejandro
An amendment to this paper has been published and can be accessed via the original article.
Environmental and Lifestyle Risk Factors in the Carcinogenesis of Gallbladder Cancer
(2022) Pérez Moreno, Pablo; Riquelme, Ismael; García Cañete, Patricia; Brebi, Priscilla; Roa, Juan Carlos
Gallbladder cancer (GBC) is an aggressive neoplasm that in an early stage is generally asymptomatic and, in most cases, is diagnosed in advanced stages with a very low life expectancy because there is no curative treatment. Therefore, understanding the early carcinogenic mechanisms of this pathology is crucial to proposing preventive strategies for this cancer. The main risk factor is the presence of gallstones, which are associated with some environmental factors such as a sedentary lifestyle and a high-fat diet. Other risk factors such as autoimmune disorders and bacterial, parasitic and fungal infections have also been described. All these factors can generate a long-term inflammatory state characterized by the persistent activation of the immune system, the frequent release of pro-inflammatory cytokines, and the constant production of reactive oxygen species that result in a chronic damage/repair cycle, subsequently inducing the loss of the normal architecture of the gallbladder mucosa that leads to the development of GBC. This review addresses how the different risk factors could promote a chronic inflammatory state essential to the development of gallbladder carcinogenesis, which will make it possible to define some strategies such as anti-inflammatory drugs or public health proposals in the prevention of GBC.
Evaluation of DNA methylation in promoter regions of SFRP4 and ZAR1 in urine and plasma of women with cervical lesions
(2017) Hoffstetter, Rene; Riquelme, Ismael; Andana, Alejandra; Ili, Carmen G.; Buchegger, Kurt; Vargas, Hernan; Brebi, Priscilla; Roa Strauch, Juan Carlos Enrique
Exploring the Genetic Diversity of Epstein–Barr Virus among Patients with Gastric Cancer in Southern Chile
(2023) Reyes, María Elena; Zanella, Louise; Riquelme, Ismael; Buchegger, Kurt; Mora-Lagos, Bárbara; Guzmán, Pablo; García Cañete, Patricia; Roa Strauch, Juan Carlos Enrique; Gloria Ili, Carmen; Brebi, Priscilla
The Epstein–Barr virus (EBV) has been associated with gastric cancer (GC), one of the deadliest malignancies in Chile and the world. Little is known about Chilean EBV strains. This study aims to investigate the frequency and genetic diversity of EBV in GC in patients in southern Chile. To evaluate the prevalence of EBV in GC patients from the Chilean population, we studied 54 GC samples using the gold standard detection method of EBV-encoded small RNA (EBER). The EBV-positive samples were subjected to amplification and sequencing of the Epstein–Barr virus nuclear protein 3A (EBNA3A) gene to evaluate the genetic diversity of EBV strains circulating in southern Chile. In total, 22.2% of the GC samples were EBV-positive and significantly associated with diffuse-type histology (p = 0.003). Phylogenetic analyses identified EBV-1 and EBV-2 in the GC samples, showing genetic diversity among Chilean isolates. This work provides important information for an epidemiological follow-up of the different EBV subtypes that may cause GC in southern Chile.
Immunohistochemical Expression of Vascular Endothelial Growth Factor A in Advanced Gallbladder Carcinoma
(2014) Letelier, Pablo; García Cañete, Patricia; Leal, Pamela; Ili, Carmen; Buchegger, Kurt; Riquelme, Ismael; Sandoval, Alejandra; Tapia, Oscar; Roa Strauch, Juan Carlos Enrique
LINC00662 Promotes Aggressive Traits by Modulating OCT4 Expression through miR-335-5p in Gallbladder Cancer Cells
(MDPI, 2024) Perez-Moreno, Pablo; Riquelme, Ismael; Bizama Soto, Carolina Del Carmen; Vergara-Gomez, Luis; Tapia, Julio C.; Brebi, Priscilla; Garcia Canete, Patricia Del Carmen; Roa Strauch, Juan Carlos Enrique
Long non-coding RNAs (lncRNAs) are nucleotide sequences that participate in different biological processes and are associated with different pathologies, including cancer. Long intergenic non-protein-coding RNA 662 (LINC00662) has been reported to be involved in different cancers, including colorectal, prostate, and breast cancer. However, its role in gallbladder cancer has not yet been described. In this article, we hypothesize that LINC00662 has an important role in the acquisition of aggressiveness traits such as a stem-like phenotype, invasion, and chemoresistance in gallbladder cancer. Here, we show that LINC00662 is associated with larger tumor size and lymph node metastasis in patients with gallbladder cancer. Furthermore, we show that the overexpression of LINC00662 promotes an increase in CD133+/CD44+ cell populations and the expression of stemness-associated genes. LINC00662 promotes greater invasive capacity and the expression of genes associated with epithelial-mesenchymal transition. In addition, the expression of LINC00662 promotes resistance to cisplatin and 5-fluorouracil, associated with increased expression of chemoresistance-related ATP-binding cassette (ABC) transporters in gallbladder cancer (GBC) cell lines. Finally, we show that the mechanism by which LINC00662 exerts its function is through a decrease in microRNA 335-5p (miR-335-5p) and an increase in octamer-binding transcription factor 4 (OCT4) in GBC cells. Thus, our data allow us to propose LINC00662 as a biomarker of poor prognosis and a potential therapeutic target for patients with GBC.
Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice
(2015) Weber, Helga; Leal, Pamela; Stein, Stefan; Kunkel, Hana; García Cañete, Patricia; Bizama, Carolina; Espinoza, Jaime A.; Riquelme, Ismael; Nervi Nattero, Bruno; Araya, Juan C.; Grez, Manuel; Roa Strauch, Juan Carlos Enrique
Reprimo, a Potential p53-Dependent Tumor Suppressor Gene, Is Frequently Hypermethylated in Estrogen Receptor Alpha-Positive Breast Cancer
(2017) Buchegger, Kurt; Riquelme, Ismael; Viscarra, Tamara; Ili, Carmen; Brebi, Priscilla; Hui-Ming Huang, Tim; Roa Strauch, Juan Carlos Enrique
Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer
(2017) Weber, Helga; Valbuena Mora, José Rafael; Barbhuiya, Mustafa A.; Stein, Stefan; Kunkel, Hana; García Muñoz, Patricia; Bizama, Carolina; Riquelme, Ismael; Espinoza, Jaime A.; Kurtz, Stephen E.; Tyner, Jeffrey W.; Calderon, Juan Francisco; Corvalán R., Alejandro; Grez, Manuel; Pandey, Akhilesh; Leal Rojas, Pamela; Roa Strauch, Juan Carlos Enrique
The conundrum of the Epstein-Barr virus-associated gastric carcinoma in the Americas
(2017) Carrasco Avino, Gonzalo; Riquelme, Ismael; Padilla, Oslando; Villaseca, Miguel; Aguayo González, Francisco; Corvalán R., Alejandro
The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer
(2017) Buchegger, Kurt; Silva, Ramón; López, Jaime; Lli, Carmen; Araya, Juan Carlos; Leal, Pamela; Brebi, Priscilla; Riquelme, Ismael; Roa Strauch, Juan Carlos Enrique
The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines
(2016) Riquelme, Ismael; Tapia, Óscar; Espinoza, Jaime A.; Leal, Pamela; Buchegger, Kurt; Sandoval, Alejandra; Bizama, Carolina; Araya, Juan Carlos; Peek, Richard M.; Roa Strauch, Juan Carlos Enrique

Browsing by Author "Riquelme, Ismael"

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