Browsing by Author "Rigotti Rivera, Attilio Gianpietro"

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    El síndrome metabólico: de factor agravante a principal factor de riesgo patogénico en diversas enfermedades crónicas
    (2010) Von Bernhardi Montgomery, Rommy Edth B.; Zanlungo Matsuhiro, Silvana; Arrese Jiménez, Marco Antonio; Arteaga Llona, Antonio Alberto; Rigotti Rivera, Attilio Gianpietro
    In recent years, a rapidly increasing number of studies have focused on the association between metabolic syndrome and several chronic diseases. However, it is difficult to determine a well defined pathogenic relationship, due to the etiological heterogeneity and comorbidities of these diseases. Research efforts are aiming to identify the convergent biological mechanisms that mediate the effects of hyperinsulinemia, hyperglycemia, dyslipidemia, and hypertension. All these conditions define the metabolic syndrome, that increases the risk for several diseases. The knowledge of these biological mechanisms associated with this syndrome will elucidate the pathogenic association between a variety of chronic diseases, including its pathogenic link with cardiovascular diseases and the most common forms of dementia. The development of new therapeutic and preventive strategies for these diseases will be a corollary of this research.
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    Hepatic cholesterol transport from plasma into bile: implications for gallstone disease
    (2004) Zanlungo Matsuhiro, Silvana; Rigotti Rivera, Attilio Gianpietro; Nervi Oddone, Flavio
    Purpose of reviewThe transhepatic traffic of cholesterol from plasma lipoproteins into the bile is critical for overall cholesterol homeostasis and its alterations may lead to cholesterol gallstone formation. This review summarizes recent progress in understanding the key hepatic cholesterol metabolism-related proteins and pathways that influence biliary secretion of cholesterol.Recent findingsIn cholesterol-fed apolipoprotein E knockout mice, the availability of dietary cholesterol for biliary disposal is decreased and diet-induced gallstone formation is impaired. Scavenger receptor class B type I is relevant for cholesterol transport from plasma HDL into the bile in chow-fed mice, however its expression is not critical for biliary cholesterol secretion and gallstone formation in lithogenic diet-fed mice. Intrahepatic cholesterol transport proteins (e.g. sterol carrier protein-2, Niemann Pick type C-1 protein) also determine liver cholesterol available for biliary secretion in mice. Genetic manipulation of canalicular ATP-binding cassette transporter G5 and G8 expression in mice has established their essential role for biliary cholesterol secretion.SummaryRecent studies have underscored that different proteins involved in hepatic cholesterol transport regulate the availability of cholesterol for biliary secretion. These advances may provide new avenues for prevention and treatment of various disease conditions linked to abnormal cholesterol metabolism.
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    [Molecular biology and medicine: basic concepts]
    (1999) Zanlungo Matsuhiro, Silvana; Rigotti Rivera, Attilio Gianpietro; Arrese Jiménez, Marco Antonio
    Through the advancements of molecular genetics, physicians and researchers are in an extraordinary period of study concerning the molecular basis of medicine. Molecular biology is making a tremendous impact on both diagnosis and treatment of diseases through the clinical introduction of molecular methods. These techniques, restricted for many years to basic biological research, include the polymerase chain reaction, DNA and protein electrophoresis, cloning of genes into viral or bacterial vectors and methods to rapidly sequence DNA and identify mutations. In this article the authors attempt to provide basic concepts on these themes for the non-trained physicians in order to help them to understand recent developments and foresee their future implications.
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    The ABCs of biliary cholesterol secretion and their implication for gallstone disease
    (2003) Zanlungo Matsuhiro, Silvana; Miquel Poblete, Juan Francisco; Rigotti Rivera, Attilio Gianpietro; Nervi Oddone, Flavio