Browsing by Author "Riera Cassorla, Francisca Paz"

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    Clusters of Autoimmune Diseases in Children and the Role of PTPN22 C1858T Gene Polymorphism in Pediatric Polyautoimmunity
    (2014) Borzutzky Schachter, Arturo; Seiltgens, Cristián; Iruretagoyena B., Mirentxu; Cristi, Francisca; Ponce, María Jesús ; Melendez, Patricia; Martínez Aguayo, Alejandro; Hodgson Bunster, María Isabel; Talesnik Guendelman, Eduardo; Riera Cassorla, Francisca Paz; Méndez, Cecilia; Harris D., Paul R.; García Bruce, Hernán; Gana Ansaldo, Juan Cristóbal; Godoy, Claudia; Cattani Ortega, Andreína
    Background/Purpose:Autoimmune diseases (AIDs) have familial aggregation and frequently share a common genetic background, but few studies have evaluated autoimmune clusters in children with AIDs and their families. Children with more than one AID (pediatric polyautoimmunity) may have a stronger genetic component than children with a single AID. The objectives of this study were to identify clusters of AIDs in children and their first-degree relatives and to evaluate the association of PTPN22 C1858T gene polymorphism with pediatric polyautoimmunity.Methods:A cross-sectional study was performed in subjects with an AID of pediatric onset (<18 years)recruited at Pediatric Rheumatology, Endocrinology and Gastroenterology Clinics at the Health Network of the Pontificia Universidad Católica de Chile School of Medicine. Clusters of AIDs were identified by K-means cluster analysis. The PTPN22 C1858T gene polymorphism was determined by RT-PCR in subjects with pediatric polyautoimmunity and in subjects with three common AIDs: juvenile idiopathic arthritis (JIA), autoimmune thyroid disease (AITD), and type I diabetes (T1D).Results:191 subjects with pediatric AIDs were included, of which 45 (24%) had polyautoimmunity. Mean age was 12.1 years (range 1–19) and 68% were female. Most frequent AIDs were JIA (36%), AITD (25%), T1D (19%), uveitis (8%), celiac disease (6%), and vitiligo (6%). 59% of subjects with pediatric autoimmunity had first-degree relatives with an AID. Five clusters of AID were identified in families of children with autoimmunity (Table 1). Among the 45 subjects with pediatric polyautoimmunity, four clusters of AIDs were identified (Table 2). Genomic DNA from 128 subjects was evaluated for PTPN22 C1858T gene polymorphism revealing common homozygosity (C/C) in 85.2%, heterozygosity (C/T) in 13.3%, and rare homozygosity (T/T) in 1.6 %, in equilibrium with Hardy Weinberg equation (P = 0.4). 26% of polyautoimmune subjects had the T allele in contrast with 11% of monoautoimmune subjects (P = 0.04). No significant difference was found in the age of onset of autoimmunity between mono and polyautoimmune subjects (P = 0.44) or between subjects with C/C genotype vs. C/T and T/T genotypes (P = 0.81).
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    Clusters of Autoinmune Diseases in Children
    (KARGER, 2016) Seiltgens, Sorrel Cristian; Iruretagoyena Bruce, Mirentxu Ines; Melendez Escobar, Patricia Eugenia; Ponce Arqueros, Maria Jesus; Talesnik Guendelman, Eduardo; Méndez Rivera, Cecilia Del Pilar; Godoy Cortes, Claudia Loreto; Martinez Aguayo, Alejandro Gregorio; Hogdson, Isabel; Harris Diez, Paul Richard; Gana, Juan Cristobal; Riera Cassorla, Francisca Paz; Garcia Bruce, Hernán Gabriel; Cattani Ortega, Andreina; Borzutzky Schachter, Arturo Jose
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    Helicobacter pylori infection in children is associated with a mucosal T regulatory cell response and less severe gastritis than that of adults
    (2007) Wright, Shelton W.; Smythies, Lesley; Riera Cassorla, Francisca Paz; Espinoza Torres, Javiera Marcela; Novak, Lea; Schmitz, Julia; Lorenz, Robin G.; Serrano Honeyman, Carolina Andrea; Harris Diez, Paul Richard; Smith, Phillip D.
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    Peptic Ulcer Disease in Helicobacter pylori-Infected Children : Clinical Findings and Mucosal Immune Response
    (2014) Hernández C.; Serrano Honeyman, Carolina; Einisman, H.; Villagrán, A.; Peña Villegas, Alfredo Javier; Duarte, Ignacio; Torres Montes, Paula Javiera; Riera Cassorla, Francisca Paz; Harris D., Paul R.; Hernández C.; Serrano Honeyman, Carolina; Einisman, H.; Villagrán, A.; Peña Villegas, Alfredo Javier; Duarte, Ignacio; Torres Montes, Paula Javiera; Riera Cassorla, Francisca Paz; Harris D., Paul R.