Browsing by Author "Reyes Zaldívar, Felipe Tomas"

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Acoso laboral y sexual hacia residentes en Chile
    (2017) Reyes Zaldívar, Felipe Tomas; Rodríguez Rückert, Ignacio; Grasset Escobar, Eugenio; Cuadrado Nahum, Cristóbal; Zuñiga Valpreda, Carlos
  • Thumbnail Image
    Item
    Cat-scratch Disease in the Pediatric Population
    (2020) Reyes Zaldívar, Felipe Tomas; Sandoval, Alejandra C.; Prado Sanhueza, Maria Alejandra; Peña Donati, Anamaria; Viviani Salgado, Tamara Nieves
    Background: Bartonella henselae is the etiologic agent of cat-scratch disease, which affects the entire world population. Due to how poorly characterized the child population is, the objective was to describe the clinical behavior of this disease in children younger than 16 years of age. Methods: This was a descriptive study with prospective follow-up of all children younger than 16 years with clinical and serologic diagnoses between 2013 and 2018. Results: There were 142 patients; of these, 55.6% had localized disease, 34.5% disseminated with hepatosplenic involvement and 9.8% had atypical disease. The cases of atypical disease were prolonged febrile illness, Parinaud syndrome, subacute bacterial endocarditis/glomerulonephritis and aseptic meningitis. Cervical lymphadenopathy was the most frequent, followed by inguinal adenopathy. There were no differences between the type of manifestation and laboratory values except for a higher erythrocyte sedimentation rate tendency in patients with disseminated and/or atypical disease. The serologic titers throughout were distributed as follows: titer of 1/1024, 71.7%; titer of 1/512, 10.4% and titer of 1/256, 17.9%. Conclusions: This is, to our knowledge, the largest series of cat-scratch disease published. We demonstrate that in our environment, the inguinal location is suggestive of this disease, the disseminated presentation, frequent, and that the titers are probably much higher than in other populations, which perhaps indicates the need to re-examine the cut-off point for positivity.
  • Thumbnail Image
    Item
    Evaluación de la sensibilidad diagnóstica de tres técnicas de laboratorio para la infección por influenza A: inmunocromatografía, IFD e IFD con citocentrifugado versus RPC-TR
    (SOC CHILENA INFECTOLOGIA, 2014) Wilhelm, Jan; Yubero, Joao; Fuentes, Constanza; Rios, Paulina; Leyton, Oscar; Reyes Zaldívar, Felipe Tomas
    Introduction: The specific diagnosis of influenza A infection makes. it possible to control its spread, decreases the unnecessary use of antibiotics, clinical procedures and laboratory test, and allows early recognition of outbreaks. Different technologies are currently available in Chile for this purpose. Objective: The study presented here compares the sensitivity for influenza A virus detection of immunocromatography (RIDT), direct fluorescent antibodies-DFA and DFA with cytocentrifugation against the gold standard, RT-PCR. Material and Methods: In 175 nasal swab samples influenza, RIDT and RT-PCR were performed. Another 1689 nasal swab samples were tested by DFA and RT-PCR for influenza A. Finally, 29 nasal swab samples confirmed as Influenza A positive by RT-PCR welt tested by DFA with cytocentrifugation. Results: The RIDT, DFA and DFA + cytocentrifugation sensitivity was 47,3%, 57,2% and 72,4%, respectively. Discussion and Conclusion: Their lower cost and faster turnaround time when compared to PCR make RIDT and DFA the tests of choice in diagnostic laboratories in Chile. However, their low sensitivity and NPV, especially during low season, makes more sensitive diagnostic tools necessary to confirm the results. In our study cytocentrifugation increased DFA sensitivity from 57% to 72%.