Browsing by Author "Retamal, Yasmina"

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    Epstein-Barr virus-associated primary lymphoepitheliomalike carcinoma of the esophagus
    (LIPPINCOTT WILLIAMS & WILKINS, 2007) Valbuena, Jose Rafael; Retamal, Yasmina; Bernal, Carolina; Eizuru, Yoshito; Corvalan, Alejandro
    Primary lymphoepitheliomalike carcinomas (LELC) of the esophagus are uncommon, with only 29 previously reported cases in the literature. Primary LELC of the esophagus is associated with Epstein-Barr virus (EBV). We herein report a 52-year-old man who presented with dysphagia and weight loss and was found to have a polypoid mass in the middle esophagus. Pathologic examination showed LELC. EBV infection was demonstrated by immunohistochemical detection of EBNA-1 in neoplastic cells and polymerase chain reaction amplification for EBNA-3C, BamHI-F, and W1/I1 regions but not by in situ hybridization by EBER-1 transcripts. EBV genotyping analysis demonstrated infection by a novel type "i"/XhoI loss recombinant strain. Although it is accepted that polymorphisms at BamHI-W1/I1 region cosegregate with polymorphisms at XhoI restriction site, this novel recombinant EBV has been identified in healthy donors and in nasal NK/T-cell lymphoma. To our knowledge, this is the first report that describes this recombinant type "i"/XhoI loss EBV strain in a primary LELC of the esophagus.
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    Intestinal isosporiasis in patients with acquired immunodeficiency syndrome (AIDS). pathologic diagnosis in small intestinal mucosal biopsies
    (2018) Oddo Benavides, David; Mendez Olivieri, Gonzalo Patricio; Retamal, Yasmina; Oddó, Aarón