Browsing by Author "Rafael Guilen de Oliveira"

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    Swimming exercise attenuates diabetic myopathy and is associated with histological and mitochondrial changes in pregnant rats (Rattus norvegicus)
    (2026) Catinelli, Bruna Bologna; Pascon Barbosa, Angélica Mércia; Medolago Carr, Aline; Rafael Guilen de Oliveira; Bergamo Alves, Fernanda Cristina; Mosele, Franciele; Chies, Agnaldo Bruno; Felisbino, Sérgio Luis; Sobrevia Luarte, Luis Alberto; Souza Rossignoli, Patrícia de; Vieira Cunha Rudge, Marilza
    Aim: Diabetic-induced myopathy (DiM) is reversed by swimming exercise (SE) in diabetic pregnant rats. This study aims to characterise the role of muscle stem cells (MuSCs), mitochondrial adaptations, and inflammation in this process.Methods: A mild hyperglycaemic pregnant rat model was created by administering 100 mg/kg streptozotocin to Wistar female newborns on the first day of life. In adulthood, after mating, the rats were assigned to either a sedentary or exercise group. The SE protocol involved 60 min of daily swimming, 6 days per week, from gestational day 0 to 20. On gestational day 21, blood samples, rectus abdominis muscle (RAM), and soleus muscle were collected for analysis of fiber type, MuSCs count, mitochondrial adaptations, and inflammation markers.Results: The diabetic group showed a lower number of fast and slow-twitch fibers. SE increased the number of MuSCs, the MuSCs/myonuclei ratio, mitochondrial area, and count, and restored citrate synthase activity. SE also increased the MuSCs/fiber and myonuclei/fiber ratios, as well as the mitochondria number/fiber and mitochondria area/fiber ratios, showing a positive relationship between mitochondrial count and fiber number