Browsing by Author "Quiroga G., Teresa"

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    Biomarcadores coronarios y evolución clínica alejada en pacientes con síndromes coronarios agudos sin elevación del segmento ST
    (2005) Baeza Vergara, Ricardo Gabriel; Corbalán Herreros, Ramón; Castro Gálvez, Pablo Federico; Acevedo B., Mónica; Quiroga G., Teresa; Viviani García, Paola
    The use of new biomarkers improved risk stratification for patients with acute coronary syndromes (ACS). Aim: To evaluate the relationship between multiple biomarkers and long-term clinical outcome in ACS without ST segment elevation. Patients and Methods: Consecutive patients presenting with suspected ACS were studied. On admission to the emergency room, serum was obtained to determine highly sensitive C reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), lipoprotein (a) (LPa) and soluble P selectin (sPS). Clinical endpoints were mortality and a composite endpoint of major adverse cardiovascular events (MACE) including death, re-infarction, and angina. Results: Seventy patients, aged 63±13 years, 54 males, were studied. Final diagnosis was unstable angina in 71% and non-ST-segment elevation myocardial infarction in 29%. MACE and mortality rate were 17% and 5.8%, respectively. We found higher plasma levels of hsCRP, ESR and Lp(a) in patients with MACE (p=0.032, p=0.015 and p=0.010, respectively). Plasma levels of hsCRP and ESR were also higher in patients who died during the follow up (p=0.002 y p=0.045, respectively). Conclusion: Plasma levels of inflammatory markers and atherosclerosis biomarkers are associated with a worse long-term clinical outcome in ACS without ST segment elevation. The inclusion of these biomarkers in the routine blood test on admission, could improve risk stratification of patients with ACS in the future (Rev Méd Chile 2005; 133: 1275-93).
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    Evaluación de métodos diagnósticos para sífilis congénita
    (2000) Salazar J., Aurora; Perret P., Cecilia; Chávez P., Ana; Garcia C., Patricia; Millan O., Zunilda; Goycoolea M., Manuela; Parada B., Jacqueline; Urra M., Liliana; Ahumada H., Eugenia; Yoma B., M. Teresa; Duque O., Clara; Herman L., Odette; Quiroga G., Teresa
    Congenital syphilis is a relevant problem in our country. At the present, no routine method is available to verify the diagnostic. This multicenter prospective study recruited serum samples reactive for VDRL of sixty mothers with their respective infant (n = 120). In addition to the routinely used screening assay (RPR, VDRL) the following tests were performed: serological detection of specific antibodies to Treponema pallidum for IgM ( Pathozyme®, Captia® IgM), for IgG (Captia® IgG) and for IgG/IgM ( MHA-TP; Pathozyme competition®, ICE Syphilis®, Determine®). A good agreement was observed between the immunoassays for IgG alone or IgG/IgM (90%) and for IgM alone or IgG/IgM (87.5%). Every mother who had syphilis in the moment of the study or had had syphilis before, and her newborn child, were positive for IgG. Only 64% of the mothers with adequate treatment during their pregnancy had a positive titer for IgM and all of their newborn were not reactive for IgM. The mothers whose treatment was inadequate had IgM titers positive in 82.3% and their children had IgM positive in 11.8%. No correlation was found between a positive maternal IgM titer and the risk of the infant to present the disease. The newborn IgM titer is a useful parameter for an early diagnosis but a negative result cannot discard this pathology.