Browsing by Author "Quintero, P."
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- ItemBeneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis(2015) Pizarro, M.; Solís, Nancy; Quintero, P.; Barrera Martínez, Francisco José; Cabrera, D.; Rojas-de Santiago, P.; Arab Verdugo, Juan Pablo; Padilla, O.; Roa Strauch, Juan Carlos Enrique; Moshage, H.; Wree, A.; Inzaugarat, E.; Feldstein, A.; Fardella B., Carlos; Baudrand Biggs, René; Riquelme, A.; Arrese Jiménez, Marco
- ItemChemically induced hypoxia promotes differential outcomes over preadipocyte- or adipocyte-macrophage communication(2017) Avila-George, K.; Ramos-Olivares, K.; Vasquez-Munoz, K.; Villanueva-Morales, V.; Reyes-Farias, M.; Quintero, P.; Garcia, L.; Garcia-Diaz, D. F.Expansion of white adipose tissue induce insufficient vascularization, driving hypoxia and low-grade inflammation. Resident preadipocytes are thought to be involved. We evaluated the effects of hypoxia over preadipocytes and adipocytes, to determine which cellular type impacts the most over macrophages activation. 3T3-L1 cells were either differentiated, or maintained undifferentiated. Each group was subjected to the presence or absence of chemical hypoxia (200 mu M CoCl2) for 24 h. Conditioned media were used as treatment for murine RAW264.7 macrophages for 24 h. Gene expression of HIF-1 alpha and TNF-alpha, and the release of several markers were assessed. It was observed that culture media from hypoxic preadipocytes induced greater expression of inflammatory markers and NO release than culture media from hypoxic adipocytes, by macrophages. Gene expression correlated closer with inflammatory markers release specially on macrophages treated with conditioned media from preadipocytes. Hence, the present work highlights the importance of preadipocytes on inflammatory conditions in vitro.
- ItemNuclear control of inflammation and fibrosis in nonalcoholic steatohepatitis : therapeutic potential of dual peroxisome proliferator-activated receptor alpha/delta agonism(2013) Quintero, P.; Arrese Jiménez, Marco
- ItemRegulation of bile acid metabolism: New insights from inside(2013) Quintero, P.; Arrese Jiménez, Marco