Browsing by Author "Pollak Cornejo, Felipe"

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    Diabetes mellitus caused by a mutation of glucokinase gene. Report of an affected family
    (2017) Pollak Cornejo, Felipe; Lagos, M; Santos Martín, José Luis; Poggi, Helena; Urzúa, A; Rumié Carmi, Hana K.
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    Evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina
    (2014) Arancibia, Constanza; Galgani Fuentes, José; Valderas Igor, Juan Patricio; Morales, Mauricio; Santos Martin, José Luis; Pollak Cornejo, Felipe
    Background: In our country, the assessment of insulin resistance (IR) measuring serum insulin levels at 60 and 120 minutes after a 75 g oral glucose tolerance test (OGTT), is usual. However, there is no information about the distribution of serum insulin levels in the Chilean population. Aim: To assess the distribution of serum insulin levels at 60 and 120 minutes during OGTTs and suggest a statistical cut-off point to estimate the degree of IR. Material and Methods: Retrospective analysis of 1815 OGTTs performed in non-diabetic subjects aged between 18 and 75 years, at a university medical center. HOMA-IR (Homeostasis Model Assessment), insulin sensitivity index of Matsuda (ISI-Composite), and their correlation with serum insulin levels at 60 and 120 minutes were calculated. Results: The 75th percentiles for serum insulin levels at 60 and 120 minutes were 127 and 81 μU/mL, respectively. There was a high correlation between HOMA-IR and ISI-Composite (r = -089, p < 0.001). There was a weaker although significant correlation between HOMA-IR and ISI-Composite and insulin levels at 60 (r = 0.56 and -0.79 respectively, p < 0,001) and 120 minutes (r = 0.54 and -0.75 respectively, p < 0,001). Conclusions: We propose 60 and 120 min serum insulin levels of 130 and 80 μU/mL respectively, as cut-off values for normality during OGTT in Chilean normoglycemic individuals.
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    II Consenso de la Sociedad Chilena de Endocrinología y Diabetes sobre resistencia a la insulina
    (2015) Pollak Cornejo, Felipe; Araya, Verónica; Lanas, Alejandra; Arrese Jiménez, Marco; Galgani Fuentes, José; García Bruce, Hernán; Maiz Gurruchaga, Manuel Alberto; Valderas Igor, Juan Patricio; Villaseca Délano, Paulina