Browsing by Author "Piddo, Ana M."

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    Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat Goldblatt model
    (LIPPINCOTT WILLIAMS & WILKINS, 2002) Ocaranza Jeraldino, María Paz; Piddo, Ana M.; Faundez, Perla; Lavandero, Sergio; Jalil Milad, Jorge Emilio
    Background and objective In humans, the insertion/ deletion polymorphism in the anglotensin (Ang) I converting enzyme (ACE) gene significantly determines ACE activity. The deletion allele induces higher ACE levels and is associated with hypertension in men. In the rat, a microsatellite marker in the ACE gene allows differentiation of the ACE alleles among strains with different ACE levels. We evaluated the effect of genetically determined ACE expression on the development of renovascular hypertension in the rat.
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    Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat Goldblatt model
    (LIPPINCOTT WILLIAMS & WILKINS, 2002) Ocaranza Jeraldino, María Paz; Piddo, Ana M.; Faundez, Perla; Lavandero, Sergio; Jalil Milad, Jorge Emilio
    Background and objective In humans, the insertion/ deletion polymorphism in the anglotensin (Ang) I converting enzyme (ACE) gene significantly determines ACE activity. The deletion allele induces higher ACE levels and is associated with hypertension in men. In the rat, a microsatellite marker in the ACE gene allows differentiation of the ACE alleles among strains with different ACE levels. We evaluated the effect of genetically determined ACE expression on the development of renovascular hypertension in the rat.