Browsing by Author "Pettinelli Rocha, Paulina Pilar"
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- ItemAltered hepatic genes related to retinol metabolism and plasma retinol in patients with non-alcoholic fatty liver disease(2018) Pettinelli Rocha, Paulina Pilar; Arendt, Bianca M.; Teterina, Anastasia; McGilvray, Ian; Comelli, Elena M.; Fung, Scott K.; Fischer, Sandra E.; Allard, Johane P.
- ItemAssociation between food addiction and nutritional status in Chilean college students(2015) Obregon, A.; Fuentes, J.; Pettinelli Rocha, Paulina PilarBackground: High calorie foods, especially high in sugar and sodium may have an addictive potential. Experimental rats are able to develop symptoms and neuro chemical changes, comparable to those observed in drug abuse, when they are exposed intermittently to sucrose. Aim: To evaluate the association between nutritional status and the prevalence of food addiction in Chilean college students. Material and Methods: Food addiction was assessed using the Yale Food Addiction Scale in 292 Chilean students aged 18-39 years (35% males). Height and weight were measured and body mass index (weight/height(2)) was calculated. Results: Eleven percent of participants met the criteria for food addiction. Women had a higher prevalence than men (14.4% and 4.8%, respectively). Thirty percent of individuals with a body mass index over 30 kg/m(2) met the criteria for food addiction. Conclusions: In these Chilean students, food addiction was more prevalent in women and a higher prevalence was observed in obese individuals.
- ItemChildhood obesity and eating behaviour(2015) Obregon, A. M.; Pettinelli Rocha, Paulina Pilar; Santos Martín, José LuisThe prevalence of childhood obesity has increased substantially in the recent decade as a result of the reduction in physical activity and the availability of high-fat and high-energy-density foods which the paediatric population faces daily. Although children are highly exposed to these foods, there is a wide variation in body weight, suggesting the presence of different patterns of response to an "obesogenic" environment. This wide variability from the point of view of eating behaviour involves a number of social issues (e.g., food availability, cost) as well as genuine behavioural traits such as the response to satiety, energy compensation, eating rate, responsiveness to food, food reward and dietary preferences. This article reviews the main physiological variables related to energy intake affecting eating behaviour in the paediatric population.
- ItemConsumo de fructosa y sus implicaciones para la salud: malabsorción de fructosa e hígado graso no alcohólico(2014) Riveros Hermans, María Jesús; Parada Daza, Alejandra; Pettinelli Rocha, Paulina Pilar
- ItemProductos finales de glicación avanzada y marcadores de daño hepático en sujetos con enfermedad de hígado graso no alcohólico.(2020) Priken Figueroa, Kathleen Maureen; Pettinelli Rocha, Paulina Pilar; Tapia Opazo, Gladys Sofía; Pontificia Universidad Católica de Chile. Facultad de MedicinaIntroducción. Los productos finales de glicación avanzada (AGE) se forman endógenamente en resistencia a la insulina, estrés oxidativo y peroxidación lipídica. Su presencia se ha asociado con la enfermedad de hígado graso no alcohólico (EHGNA) por posible estimulación de estrés oxidativo, inflamación, fibrosis y apoptosis. Objetivo. Relacionar la presencia de AGE, su receptor y marcadores de daño hepático en sujetos con EHGNA y controles sin la enfermedad. Metodología. Estudio observacional transversal en sujetos de 18 a 65 años con EHGNA (n=7 esteatosis-ES; n=15 esteatohepatitis-EH) y controles sin la enfermedad (n=11). Se analizaron características histológicas, parámetros bioquímicos plasmáticos, AGE séricos y su receptor (sRAGE) (ELISA), las proteínas hepáticas α-SMA, TGF-β1 y AGE (inmunohistoquímica) y expresión de mRNA de RAGE, TGF-β1, MCP-1 y NOX4 (RT-qPCR). Resultados. El puntaje NAS en EH fue 4.9 ± 1.3, ES 2.0 ± 1.0 y 0.2 ± 0.6 en controles (p<0,0001). Los AGE hepáticos mostraron tinción intensa en citoplasma de hepatocitos con esteatosis micro y macrovesicular e intensidad leve en zonas fibróticas alrededor de vasos hepáticos. La intensidad fue mayor en EH [2.94 (2.30-4.37)]x107 versus ES [1.45 (1.21-2.33)] x107(p=0.021). El puntaje NAS 5-8 [3.43 (2.68-5.15)]x107 fue mayor a NAS 0 [1.73 (1.38-3.42)]x107 (p=0.017) y NAS 1-4 [2.30 (1.33-2.68)]x107 (p=0.014). En sujetos con EH, TGF-β1 y α-SMA demostraron tinción intensa en zonas fibróticas.Conclusión. El rol de AGE séricos y sRAGE sobre la acumulación de AGE hepáticos podría ser secundario en sujetos con EHGNA, siendo más relevantes los AGE formados dentro del propio hígado.
- ItemRole of dietary α- and γ-tocopherol from Rosa mosqueta oil in the prevention of alterations induced by high-fat diet in a murine model(2018) Tapia, Gladys; Silva, David; Romero, Nalda; Pettinelli Rocha, Paulina Pilar; Dossi, Camila G.; De Miguel, Manuel; González-Mañán, Daniel