Browsing by Author "Pedemonte Trewhela, Juan Cristóbal"

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    A combined iron and thyroid hormone protocol suppresses ischemia-reperfusion injury in rat livers
    (2015) Pedemonte Trewhela, Juan Cristóbal; Vargas, R.; Castillo, V.; Hodali, T.
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    A Pharmacokinetic and Pharmacodynamic Study of Oral Dexmedetomidine
    (2020) Chamadia, S.; Pedemonte Trewhela, Juan Cristóbal; Hobbs, L. E.; Deng, H.; Nguyen, S.; Cortínez Fernández, Luis Ignacio; Akeju, O.
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    A polysomnography study examining the association between sleep and postoperative delirium in older hospitalized cardiac surgical patients
    (2021) Reine, Ibala; Mekonnen, Jennifer; Gitlin, Jacob; Hah, Eunice Y.; Ethrid, Breanna R.; Colon, Katia M.; Marota, Sophia; Orte, Cristy; Pedemonte Trewhela, Juan Cristóbal; Cobanaj, Marisa; Chamadia, Shubham; Qu, Jason; Gao, Lei; Barbieri, Riccardo; Akej, Oluwaseun
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    Comparación preoperatoria entre pruebas de coagulación y tromboelastografía en pacientes con cirrosis hepática sometidos a trasplante hepático
    (2018) Concha P., Mario; Mertz K., Veronica; Muñoz Castillo, Gabriel; Delfino, Alejandro; Cortínez Fernández, Luis Ignacio; Montaña Rodríguez, Rodrigo; Pedemonte Trewhela, Juan Cristóbal; Fuentes Henríquez, Ricardo Sergio
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    Control-flow analysis of procedural skills competencies in medical training through process mining
    (2020) Fuente Sanhueza, René Francisco de la; Fuentes Henríquez, Ricardo Sergio; Muñoz Gama, Jorge; Riquelme Pérez, Arnoldo; Altermatt, Fernando; Pedemonte Trewhela, Juan Cristóbal; Corvetto Aqueveque, Marcia Antonia; Sepúlveda Fernández, Marcos Ernesto
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    De la anestesia a la seguridad de la atención : Experiencia de 6 años en el análisis de reportes de incidentes en un hospital universitario
    (2017) Marfan, Luis; Pedemonte Trewhela, Juan Cristóbal; Sandoval, Daniela; Ferdinand Olivares, Constanza; Camus Bustos, Lorena Beatriz; Lacassie Quiroga, Héctor
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    Dissociative and Analgesic Properties of Ketamine Are Independent
    (2020) Gitlin, J.; Chamadia, S.; Locascio, J. J.; Ethridge, B. R.; Pedemonte Trewhela, Juan Cristóbal; Hahm, E. Y.; Ibala, R.; Mekonnen, J.; Colon, K. M.; Qu, J.; Akeju, O.
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    Effect of nitric oxide on postoperative acute kidney injury in patients who underwent cardiopulmonary bypass: a systematic review and meta-analysis with trial sequential analysis
    (2019) Hu, Jie.; Pedemonte Trewhela, Juan Cristóbal; Spina, Stefano.; Zadek, Francesco.; Kamenshchikov, Nikolay O.; Bittner, Edward A.; Berra, Lorenzo.
    Abstract Background The effect of nitric oxide (NO) on renal function is controversial in critical illness. We performed a systematic meta-analysis and trial sequential analysis to determine the effect of NO gas on renal function and other clinical outcomes in patients requiring cardiopulmonary bypass (CPB). The primary outcome was the relative risk (RR) of acute kidney injury (AKI), irrespective of the AKI stage. The secondary outcome was the mean difference (MD) in the length of ICU and hospital stay, the RR of postoperative hemorrhage, and the MD in levels of methemoglobin. Trial sequential analysis (TSA) was performed for the primary outcome. Results 54 trials were assessed for eligibility and 5 studies (579 patients) were eligible for meta-analysis. NO was associated with reduced risk of AKI (RR 0.76, 95% confidential interval [CI], 0.62 to 0.93, I2 = 0%). In the subgroup analysis by NO initiation timing, NO did not decrease the risk of AKI when started at the end of CPB (RR 1.20, 95% CI 0.52–2.78, I2 = 0%). However, NO did significantly reduce the risk of AKI when started from the beginning of CPB (RR 0.71, 95% CI 0.54–0.94, I2 = 10%). We conducted TSA based on three trials (400 patients) using KDIGO criteria and with low risk of bias. TSA indicated a CI of 0.50–1.02 and an optimal information size of 589 patients, suggesting a lack of definitive conclusion. Furthermore, NO does not affect the length of ICU and hospital stay or the risk of postoperative hemorrhage. NO slightly increased the level of methemoglobin at the end of CPB (MD 0.52%, 95% CI 0.27–0.78%, I2 = 90%), but it was clinically negligible. Conclusions NO appeared to reduce the risk of postoperative AKI in patients undergoing CPB. Additional studies are required to ascertain the finding and further determine the dosage, timing and duration of NO administration.
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    Electroencephalogram Burst-suppression during Cardiopulmonary Bypass in Elderly Patients Mediates Postoperative Delirium
    (2020) Pedemonte Trewhela, Juan Cristóbal; Plummer, G. S.; Chamadia, S.; Locascio, J. J.; Hahm, E.; Ethridge, B.; Gitlin, J.; Ibala, R.; Mekonnen, J.; Colon, K. M.; Westover, M. B.; D'Alessandro, D. A.; Tolis, G.; Houle, T.; Shelton, K. T.; Qu, J.; Akeju, O.
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    NO production and eNOS phosphorylation induced by epinephrine through the activation of β-adrenoceptors
    (2009) Figueroa, Xavier; Cortés Mora, Víctor Antonio; Huidobro-Toro, Juan Pablo.; Poblete, Inés; Fernández Acevedo, Ricardo Hernán; Pedemonte Trewhela, Juan Cristóbal
    Epinephrine plays a key role in the control of vasomotor tone; however, the participation of the NO/cGMP pathway in response to β-adrenoceptor activation remains controversial. To evaluate the involvement of the endothelium in the vascular response to epinephrine, we assessed NO production, endothelial NO synthase phosphorylation, and tissue accumulation of cGMP in the perfused arterial mesenteric bed of rat. Epinephrine elicited a concentration-dependent increase in NO (EC50 of 45.7 pM), which was coupled to cGMP tissue accumulation. Both NO and cGMP production were blocked by either endothelium removal (saponin) or NO synthase inhibition (Nω-nitro-l-arginine). Blockade of β1- and β2-adrenoceptors with 1 μM propranolol or β3-adrenoceptor with 10 nM SR 59230A displaced rightward the concentration-NO production curve evoked by epinephrine. Selective stimulation of β1-, β2-, or β3-adrenoceptors also resulted in NO and cGMP production. Propranolol (1 μM) inhibited the rise in NO induced by isoproterenol or the β2-adrenoceptor agonists salbutamol, terbutaline, or fenoterol. Likewise, 10 nM SR 59230A reduced the effects of the β3-adrenoceptor agonists BRL 37344, CGP 12177, SR 595611A, or pindolol. The NO production induced by epinephrine and BRL 37344 was associated with the activation of the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of eNOS in serine 1177. In addition, in anaesthetized rats, bolus administration of isoproterenol, salbutamol, or BRL 37344 produced NO-dependent reductions in systolic blood pressure. These findings indicate that β1-, β2-, and β3-adrenoceptors are coupled to the NO/cGMP pathway, highlighting the role of the endothelium in the vasomotor action elicited by epinephrine and related β-adrenoceptor agonists.
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    Oral Dexmedetomidine Promotes Non-rapid Eye Movement Stage 2 Sleep in Humans
    (2020) Chamadia, S.; Hobbs, L.; Marota, S.; Ibala, R.; Hahm, E.; Gitlin, J.; Mekonnen, J.; Ethridge, B.; Colon, K. M.; Pedemonte Trewhela, Juan Cristóbal; Sheppard, K. S.; Manoach, D. S.; DiBiasio, A.; Nguyen, S.; Akeju, O.
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    Simulation-based training program with deliberate practice for ultrasound-guided jugular central venous catheter placement
    (2017) Corvetto Aqueveque, Marcia Antonia; Pedemonte Trewhela, Juan Cristóbal; Varas, Diego; Fuentes, C.; Altermatt, Fernando
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    Sobrevida alejada de pacientes operados por cáncer gástrico incipiente
    (2008) Butte Barrios, Jean Michel Domingo; Torres Montes, Paula Javiera; Viviani García, Paola; Duarte, Ignacio; Crovari Eulufi, Fernando; Guzmán Karadima, Sergio; Cabrera Valenzuela, José Roberto; Pedemonte Trewhela, Juan Cristóbal; Llanos López, Osvaldo
    Background: Early gastric cancer involves mucosa and submucosa, independent of lymph node involvement. Radical gastrectomy is the standard treatment. Aim: To assess long term survival of patients operated for an early gastric cancer. Material and methods: Retrospective Rev iew of medical and pathology records of patients subjected to a gastrectomy for an early gastric cancer, between 1975 and 2002. All were treated using a standardized protocol and staged according to 2002 TNM classification of the American Joint Committee of Cáncer (AJCC). Demographic and pathologic features, operation performed and long term survival were recorded. Survival was analyzed using Kaplan-Meier method. Results: The series is comprised by 64 males and 41 females aged 61 + 1 years. Tumor was located in the upper third of the stomach on 33 subjects and a total gastrectomy was performed in 53. Pathology showed an intestinal type adenocarcinoma in 82 and a diffuse type in 23. In patients with involvement of mucosa and submucosa, 24 ± 14 and 22 ± 14 lymph nodes were excised, respectively. Lymph node involvement was present in 8% and 22% of patients with involvement of mucosa and submucosa, respectively. Five years survival was 94% and 78% in patients without and with lymph node involvement, respectively. Survival among patients in stage IA and IB was 94% and 76%, respectively. Multivariate analysis showed that the lymph node involvement was an independent mortality risk factor. Conclusions: Total gastrectomy in patients with early gastric cancer is associated with a good survival. Lymph node involvement is a mortality risk factor.