Browsing by Author "Pascon Barbosa, Angélica Mércia"

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    Melatonin and Inflammatory Cytokines as Modulators of the Interaction Between Gestational Diabetes Mellitus and Pregnancy-Specific Urinary Incontinence
    (2025) Honório França, Danielle Cristina; França, Eduardo Luzia; Honório-França, Adenilda Cristina; Rezende Silva, Kênia Maria; Ataídes de Queiroz, Adriele; Morais, Tassiane Cristina; Honorio França, Emanuelle Carolina; Frota de Carvalho, Carolina Neiva; Gomes Fagundes-Triches, Danny Laura; Pascon Barbosa, Angélica Mércia; Paranhos Calderon, Iracema de Mattos; Sobrevia Luarte, Luis Alberto; Cunha Rudge, Marilza Vieira
    Background: The pathogenesis of developing gestational diabetes mellitus (GDM) integrated with pregnancy-specific urinary incontinence (PSUI) may be related to immunological and hormonal factors. Inflammatory cytokines influence the function and regulation of the urinary tract, and changes in melatonin concentration are a predisposing factor for smooth muscle dysfunction and cystometric changes. Objective: This study examines the influence of melatonin, MT1 and MT2 receptors, and inflammatory cytokines in the blood and urine of pregnant women with GDM and PSUI. Methods: Two hundred sixty-nine pregnant women were approached during the diagnostic investigation of GDM and answered a specifically structured questionnaire about the involuntary loss of urine. According to these criteria, mothers were divided into four groups: continent normoglycemic (NG-C), incontinent normoglycemic (NG-I), continent GDM (GDM-C), and incontinent GDM (GDM-UI). Blood and urine samples were collected to determine the levels of melatonin, melatonin sulfate, melatonin receptors (MT1 and MT2), and inflammatory cytokines. Results: Blood level of melatonin and IL-10 was lower, but MT1, MT2, IL-1β, IL-8, and TNF-α were higher in GDM-UI compared with the NG-C group. The melatonin sulfate level was lower in the urine of the GDM-UI group compared with the NG-C group. Conclusions: Maternal hyperglycemia associated with urinary incontinence generates an inflammatory environment characterized by reduced melatonin and IL-10 and increased IL-1β, IL-8, and TNF-α in the blood of mothers with GDM with UI. This environmental condition may be involved in the pathogenesis of these pathologies.
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    Prevalence and Risk Factors of Pregnancy-Specific Urinary Incontinence: Findings from the Diamater Cohort Study
    (2025) Mingoranci Bassin, Henrique Caetano; Pascon Barbosa, Angélica Mércia; Baldini Prudencio, Caroline; Sobrevía Luarte, Luis Alberto; Pascon Barbosa, Vitoria; Kenickel Nunes, Sthefanie; Souza Rossignoli, Patrícia de; Rodrigues Pedroni, Cristiane; Honório França, Danielle Cristina; Bologna Catinelli, Bruna; Neiva Frota De Carvalho, Carolina; Escandiusi Avramidis, Raissa; Bittencourt Morgenstern Magyori, Adriely; Sartorao-Filho, Carlos Izaias; Vieira Cunha Rudge, Marilza
    Introduction and Hypothesis: Pregnancy-specific urinary incontinence (PS-UI) is defined as any onset of new urinary leakage during pregnancy. The study aims to analyze the prevalence and risk factors of PS-UI. We hypothesized that demographic and clinical factors, including Gestational Diabetes, may contribute to the development of PS-UI. Methods: We recruited pregnant women from the Diamater cohort study. We evaluated the maternal characteristics, demographics, anthropometrics, hyperglycemic status, and the PS-UI occurrence. A logistic regression model was performed considering the clinical variables to determine the predictive factors for PS-UI occurrence. Results: PS-UI was prevalent in 62.1% of women. Among these, 58.85% began leaking urine between 24–28 gestational weeks. Additionally, 51% developed PS-UI at the end of pregnancy. The pregestational BMI is a risk factor for PS-UI, and physical activity is a protective factor that halves the risk of PS-UI developing. Conclusions: Weight management and encouragement to engage in physical activity during pregnancy should be emphasized in prenatal care to reduce the risk of PS-UI. Further studies are suggested to evaluate the impact of the association due to UI later in life.
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    Swimming exercise attenuates diabetic myopathy and is associated with histological and mitochondrial changes in pregnant rats (Rattus norvegicus)
    (2026) Catinelli, Bruna Bologna; Pascon Barbosa, Angélica Mércia; Medolago Carr, Aline; Rafael Guilen de Oliveira; Bergamo Alves, Fernanda Cristina; Mosele, Franciele; Chies, Agnaldo Bruno; Felisbino, Sérgio Luis; Sobrevia Luarte, Luis Alberto; Souza Rossignoli, Patrícia de; Vieira Cunha Rudge, Marilza
    Aim: Diabetic-induced myopathy (DiM) is reversed by swimming exercise (SE) in diabetic pregnant rats. This study aims to characterise the role of muscle stem cells (MuSCs), mitochondrial adaptations, and inflammation in this process.Methods: A mild hyperglycaemic pregnant rat model was created by administering 100 mg/kg streptozotocin to Wistar female newborns on the first day of life. In adulthood, after mating, the rats were assigned to either a sedentary or exercise group. The SE protocol involved 60 min of daily swimming, 6 days per week, from gestational day 0 to 20. On gestational day 21, blood samples, rectus abdominis muscle (RAM), and soleus muscle were collected for analysis of fiber type, MuSCs count, mitochondrial adaptations, and inflammation markers.Results: The diabetic group showed a lower number of fast and slow-twitch fibers. SE increased the number of MuSCs, the MuSCs/myonuclei ratio, mitochondrial area, and count, and restored citrate synthase activity. SE also increased the MuSCs/fiber and myonuclei/fiber ratios, as well as the mitochondria number/fiber and mitochondria area/fiber ratios, showing a positive relationship between mitochondrial count and fiber number