Browsing by Author "Orellana Roca, Juan Andrés"
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- ItemAdolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment(2018) Tapia-Rojas, Cheril; Carvajal Cachaña, Francisco Javier; Mira, Rodrigo G.; Arce, Camila; Manuel Lerma-Cabrera, Jose; Orellana Roca, Juan Andrés; Cerpa Nebott, Waldo Francisco; Quintanilla, Rodrigo A.
- ItemAmyloid beta-Induced Death in Neurons Involves Glial and Neuronal Hemichannels(2011) Orellana Roca, Juan Andrés; Shoji Sánchez, Kenji Fabricio.; Sáez Pedraza, Pablo José.; Sáez, Juan Carlos
- ItemAstrocytes inhibit nitric oxide-dependent Ca2+ dynamics in activated microglia: Involvement of ATP released via pannexin 1 channels(2013) Orellana Roca, Juan Andrés; Montero Ossandón, Trinidad; Bernhardi Montgomery, Rommy von
- ItemATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels(2011) Orellana Roca, Juan Andrés; Sáez, Juan Carlos
- ItemCannabinoids Prevent the Amyloid beta-Induced Activation of Astroglial Hemichannels: A Neuroprotective Mechanism(2017) Gajardo Gómez, Rosario; Labra, Valeria C.; Maturana, Carola J.; Shoji, Kenji F.; Sáez, Juan Carlos; Orellana Roca, Juan Andrés
- ItemCannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments(2009) Froger, Nicolas.; Orellana Roca, Juan Andrés; Sáez, Juan Carlos
- ItemCation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species(2011) Orellana Roca, Juan Andrés; Schalper Casanova, Kurt Alex.; Vargas Ríos, Aníbal Antonio; Sáez, Juan Carlos
- ItemCell membrane permeabilization via connexin hemichannels in living and dying cells(2010) Sáez, Juan Carlos; Schalper Casanova, Kurt Alex.; Orellana Roca, Juan Andrés; Shoji Sánchez, Kenji Fabricio.
- ItemConnexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function(2018) Sáez, Juan Carlos; Contreras-Duarte, Susana; Gomez, Gonzalo I.; Labra, Valeria C.; Santibanez, Cristian A.; Gajardo Gómez, Rosario; Avendano, Beatriz C.; Diaz, Esteban F.; Montero, Trinidad D.; Velarde, Victoria; Orellana Roca, Juan Andrés
- ItemConnexin 43 hemichannels and pannexin-1 channels contribute to the alpha-synuclein-induced dysfunction and death of astrocytes(2019) Díaz Jara, Esteban Fernando; Labra Ramírez, Valeria Cristina; Alvear, Tanhia F.; Mellado, Luis A.; Inostroza, Carla A.; Oyarzún Isamitt, Juan Esteban; Salgado Cortés, Nicole Andrea; Quintanilla Gómez, Rodrigo Arthur; Orellana Roca, Juan Andrés
- ItemConnexin and pannexin hemichannels in inflammatory responses of glia and neurons(2012) Bennett, M.; Orellana Roca, Juan Andrés; Sáez, Juan Carlos
- ItemConnexins and pannexins : new insights into microglial functions and dysfunctions(2016) Gajardo Gómez, Rosario; Labra, V.; Orellana Roca, Juan Andrés
- ItemCurrently used methods for identification and characterization of hemichannels(2008) Schalper Casanova, Kurt Alex.; Palacios Prado, Nicolás.; Orellana Roca, Juan Andrés; Sáez, Juan Carlos
- ItemDisruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice(2013) Sáez Pedraza, Pablo José; Orellana Roca, Juan Andrés; Vega-Riveros, Natalia; Figueroa, Vania A.; Hernández Trejo, Diego Eduardo; Castro, Juan Francisco; Klein Posternack, Andrés David; Jean X. Jiang; Zanlungo Matsuhiro, Silvana; Sáez Carreño, Juan CarlosReduced astrocytic gap junctional communication and enhanced hemichannel activity were recently shown to increase astroglial and neuronal vulnerability to neuroinflammation. Moreover, increasing evidence suggests that neuroinflammation plays a pivotal role in the development of Niemann-Pick type C (NPC) disease, an autosomal lethal neurodegenerative disorder that is mainly caused by mutations in the NPC1 gene. Therefore, we investigated whether the lack of NPC1 expression in murine astrocytes affects the functional state of gap junction channels and hemichannels. Cultured cortical astrocytes of NPC1 knock-out mice (Npc1⁻/⁻) showed reduced intercellular communication via gap junctions and increased hemichannel activity. Similarly, astrocytes of newborn Npc1⁻/⁻ hippocampal slices presented high hemichannel activity, which was completely abrogated by connexin 43 hemichannel blockers and was resistant to inhibitors of pannexin 1 hemichannels. Npc1⁻/⁻ astrocytes also showed more intracellular Ca²⁺ signal oscillations mediated by functional connexin 43 hemichannels and P2Y₁ receptors. Therefore, Npc1⁻/⁻ astrocytes present features of connexin based channels compatible with those of reactive astrocytes and hemichannels might be a novel therapeutic target to reduce neuroinflammation in NPC disease.
- ItemEditorial : Single membrane channels formed by connexins or pannexins : focus on the nervous system(2015) Orellana Roca, Juan Andrés
- ItemExcess cholesterol induces mouse egg activation and may cause female infertility(2014) Yesilaltay, A.; Busso, Dolores; Quilaqueo Iturrieta, Linda Lien-Ale.; Orellana Roca, Juan Andrés
- ItemGap junction channels and hemichannels in the CNS : regulation by signaling molecules(2013) Orellana Roca, Juan Andrés; Martínez, Agustín; Retamal, Mauricio
- ItemGlial connexin expression and function in the context of Alzheimer's disease(2012) Koulakoff, A.; Orellana Roca, Juan Andrés; Sáez, Juan Carlos
- ItemGlial hemichannels and their involvement in aging and neurodegenerative diseases(2012) Orellana Roca, Juan Andrés; Bernhardi Montgomery, Rommy von; Sáez, Juan Carlos
- ItemHeavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats : Effects on Neuroinflammation and Astrocyte Arborization(2018) Gomez, Gonzalo I.; Falcon, Romina V.; Maturana, Carola J.; Labra, Valeria C.; Salgado Cortés, Nicole Andrea; Rojas Vidal, Consuelo Antonia; Oyarzun, Juan E.; Cerpa Nebott, Waldo Francisco; Quintanilla, Rodrigo A.; Orellana Roca, Juan Andrés