Browsing by Author "Nicklas, Claudia"

Now showing 1 - 6 of 6
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    Efficacy of topical photodynamic therapy for keratoacanthomas: A case-series of four patients
    (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2012) Farias, Maria M.; Hasson, Ariel; Navarrete, Cristian; Nicklas, Claudia; Garcia Huidobro, Isidora; Gonzalez, Sergio
    Topical photodynamic therapy (PDT) is an excellent treatment option for various non-melanoma skin cancers and precancerous lesions, including actinic keratosis, Bowen's disease, and basal cell carcinoma. The clinical use of PDT includes a broad range of neoplastic, inflammatory, and infectious skin diseases. There is also anecdotal evidence suggesting the efficacy of PDT for the treatment of keratoacanthomas (KA). We report a case-series of four patients with solitary KA confirmed by histology, treated with topical PDT with methylaminolevulinic acid (MAL) cream. After three sessions of PDT, the lesions completely disappeared. There was no evidence of recurrence and excellent cosmetic outcome was achieved after three years of follow-up. Topical photodynamic therapy with MAL can be a therapeutic alternative for KA with good clinical and cosmetic outcomes.
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    Oral and written counseling is a useful instrument to improve short-term adherence to treatment in acne patients: a randomized controlled trial
    (2015) Navarrete Dechent, Cristián Patricio; Curi Tuma, Maximiliano; Nicklas, Claudia; Cárdenas de la Torre, Consuelo Paz; Perez-Cotapos, Maria Luisa; Salomone, Claudia
    Background: Therapeutic success in acne patients not only depends in the appropriate selection of drugs but also on patient’s treatment adherence or compliance. Lack of adherence is a very important problem both in general medicine and in dermatologic practice. Objective: To evaluate the impact of oral and written counseling in adherence to treatment in acne patients. Patients and Methods: Eighty patients were randomized into a two study groups of 40 patients each in which instructions were given in a written note (besides oral counseling) and reinforced by a telephone within 15 days of onset, and a control group that received indications as usual (oral counseling in-office only). Both groups were followed-up, evaluating adherence to treatment according to self-reporting of patients at 30, 60, 90 days and 6 months. Results: Better adherence to treatment was observed in the intervention group, being statistically significant only in the first month of treatment (80% versus 62%, p = 0.043). The beneficial effect of written counseling plus a phone call diluted in subsequent months. Conclusion: Written counseling significantly improves adherence in the first month of treatment. Good adherence could also lead to more effective treatments so it seems reasonable to use time and resources to optimize adherence to treatment.
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    Periorbital Syringoma Treated With Radiofrequency and Carbon Dioxide (CO2) Laser in 5 Patients
    (JOURNAL OF DRUGS IN DERMATOLOGY, 2012) Hasson, Ariel; Magdalena Farias, Maria; Nicklas, Claudia; Navarrete, Cristian
    Syringomas are common benign eccrine ductal adnexial tumors, commonly found in periorbital area. Periorbital syringomas are aesthetically disturbing difficult to treat. Many treatment modalities are described in the literature, including topical and surgical methods, with potential problems such as postinflammatory hyper- and hypopigmentation, low efficacy, or scar formation. We present 5 patients with syringoma treated with the combination of radiofrequency ablation and carbon dioxide (CO2) lasers. Using low-energy parameters on the CO2 laser, and low energy on the radiofrequency, we could complement both treatments maximizing the destruction of the tumors and minimizing the adverse effects in only two sessions. This is a relatively easy, safe, and less painful treatment, with good cosmetic results on periorbital syringomas.
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    The first case of tinea faciei caused by Trichophyton mentagrophytes var. erinacei isolated in Chile
    (WILEY, 2012) Concha, Marcela; Nicklas, Claudia; Balcells, Elvira; Maria Guzman, Ana; Poggi, Helena; Leon, Eugenia; Fich, Felix
    Background Trichophyton mentagrophytes var. erinacei is a zoophilic dermatophyte transmitted by hedgehogs which human infections manifest as highly inflammatory and pruritic eruptions.
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    Topical photodynamic therapy with methylaminolevulinate for the treatment of actinic keratosis and reduction of photodamage in organ transplant recipients: A case-series of 16 patients
    (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2012) Hasson, Ariel; Navarrete Dechent, Cristian; Nicklas, Claudia; de la Cruz, Claudia
    Background: Organ transplant recipients (OTR) are at high risk of developing cutaneous neoplasms. Topical photodynamic therapy (PDT) has been used for the treatment of actinic keratosis (AK) in OTR. Aims: The objective was to evaluate the efficacy of PDT with methylaminolevulinate (MAL) in the treatment of facial AK in OTR. As a secondary objective, we wanted to evaluate the usefulness of topical PDT in the reduction of photodamage in OTR. Methods: A prospective, single center, single arm study was made. 16 OTR were included. Topical PDT was applied for 1 or 2 cycles depending on the patient's characteristics. An evaluation of AK was made at visits pre-treatment, at 12 weeks and at 24 weeks. Photodamage was measured with multispectral image technique (SkinCare (R)). Results: A complete response rate of 100% was achieved for AK in all patients; it persisted without change at 12 and 24 weeks of follow-up. 62.5% of patients improved their photodamage as measured by SkinCare (R), but this result was not statistically significant (P = 0.12). All patients had high level of satisfaction at the end of the therapy. Conclusions: MAL-PDT is an effective therapy for the treatment of AK in OTRs. It can reduce photodamage in this group of patients, but these results were not statistically significant.