Browsing by Author "Neumann Burotto, Gonzalo Ignacio"

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    A methodological survey of the analysis, reporting and interpretation of Absolute Risk ReductiOn in systematic revieWs (ARROW): a study protocol
    (2013) Alonso-Coello, Pablo; Carrasco-Labra, Alonso; Brignardello-Petersen, Romina; Neumann Burotto, Gonzalo Ignacio; Akl, Elie A; Sun, Xin; Johnston, Bradley C; Briel, Matthias; Busse, Jason W; Glujovsky, Demián; Granados, Carlos E; Iorio, Alfonso; Irfan, Affan; García, Laura M; Mustafa, Reem A; Ramirez-Morera, Anggie; Solà, Iván; Tikkinen, Kari A O; Ebrahim, Shanil; Vandvik, Per O; Zhang, Yuqing; Selva, Anna; Sanabria, Andrea J; Zazueta, Oscar E; Vernooij, Robin W M; Schünemann, Holger J; Guyatt, Gordon H
    Abstract Background Clinicians, providers and guideline panels use absolute effects to weigh the advantages and downsides of treatment alternatives. Relative measures have the potential to mislead readers. However, little is known about the reporting of absolute measures in systematic reviews. The objectives of our study are to determine the proportion of systematic reviews that report absolute measures of effect for the most important outcomes, and ascertain how they are analyzed, reported and interpreted. Methods/design We will conduct a methodological survey of systematic reviews published in 2010. We will conduct a 1:1 stratified random sampling of Cochrane vs. non-Cochrane systematic reviews. We will calculate the proportion of systematic reviews reporting at least one absolute estimate of effect for the most patient-important outcome for the comparison of interest. We will conduct multivariable logistic regression analyses with the reporting of an absolute estimate of effect as the dependent variable and pre-specified study characteristics as the independent variables. For systematic reviews reporting an absolute estimate of effect, we will document the methods used for the analysis, reporting and interpretation of the absolute estimate. Discussion Our methodological survey will inform current practices regarding reporting of absolute estimates in systematic reviews. Our findings may influence recommendations on reporting, conduct and interpretation of absolute estimates. Our results are likely to be of interest to systematic review authors, funding agencies, clinicians, guideline developers and journal editors.
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    A number of factors explain why WHO guideline developers make strong recommendations inconsistent with GRADE guidance.
    (2016) Pe, Alexander; Gionfriddo Mr; Bero, L.; Neumann Burotto, Gonzalo Ignacio; Brito, Jp.; Djulbegovic, B.; Montori, V.; Norris, S. l.
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    A practical approach to evidence-based dentistry : VII How to use patient management recommendations from clinical practice guidelines
    (2015) Carrasco Labra, Alonso; Brignardello Petersen, Romina; Glick, Michael; Guyatt, Gordon H.; Neumann Burotto, Gonzalo Ignacio; Azarpazhooh, Amir
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    A user guide to the American Society of Hematology clinical practice guidelines
    (2020) Izcovich, A.; Cuker, A.; Kunkle, R.; Neumann Burotto, Gonzalo Ignacio; Panepinto, J.; Pai, M.; Seftel, M.; Cheung, M. C.; Lottenberg, R.; Byrne, M.; Plovnick, R.; Terrell, D.; Holter-Chakrabarty, J. L.; Djulbegovic, B.; Hicks, L. K.; Wiercioch, W.; Nieuwlaat, R.; Schunemann, H. J.
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    Agreements between industry and academia on publication rights: a retrospective study of protocols and publications of randomized clinical trials
    (2016) Kasenda, B.; von Elm, E.; You, J.; Blümle, A.; Tomonaga, Y.; Saccilotto, R.; Amstutz, A.; Bengoug,h T.; Meerpohl, J.; Stegert, M.; Olu, K.; Tikkinen, K.; Neumann Burotto, Gonzalo Ignacio; Carrasco Labra, A.; Faulhaber, M.; Mulla, S.; Mertz, D.; Akl, E.; Bassler, D.; Busse, J.; Ferreira González, I.; Lamontagne, F.; Nordmann, A.; Gloy, V.; Raatz, H.; Moja, L.; Ebrahim, S.; Schandelmaier, S.; Sun, X.; Vandvik, P.; Johnston, B.; Walter, M.; Burnand, B.; Schwenkglenks, M.; Hemkens, L.; Bucher, H.; Guyatt, G.; Briel, M.
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    American Gastroenterological Association Institute Technical Review on the Management of Acute Diverticulitis
    (2015) Strate, Lisa L.; Peery, Anne F.; Neumann Burotto, Gonzalo Ignacio
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    American Society of Hematology 2018 guidelines for management of venous thromboembolism : prophylaxis for hospitalized and nonhospitalized medical patients
    (2018) Schunemann, H.J.; Cushman, M.; Burnett, A.E.; Kahn, S.R.; Beyer-Westendorf, J.; Spencer, F.A.; Rezende, S.M.; Zakai, N.A.; Bauer, K.A.; Neumann Burotto, Gonzalo Ignacio; Dentali, F.
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    American Society of Hematology 2019 guidelines for management of venous thromboembolism : prevention of venous thromboembolism in surgical hospitalized patients
    (2019) Anderson, D.R.; Morgano, G.P.; Bennett, C.; Dentali, F.; Francis, C.W.; Garcia, D.A.; Kahn, S.R.; Rahman, M.; Rajasekhar, A.; Neumann Burotto, Gonzalo Ignacio; Rogers, F.B.; Smythe, M.A.
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    An analysis of protocols and publications suggested that most discontinuations of clinical trials were not based on preplanned interim analyses or stopping rules
    (2016) Stegert, M.; Kasenda, B.; Von Elm, E.; You, Jj; Blumle, A.; Tomonaga, Y.; Saccilotto, R.; Neumann Burotto, Gonzalo Ignacio
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    Answering medical questions at the point of care : a cross-sectional study comparing rapid decisions based on PubMed and Epistemonikos searches with evidence-based recommendations developed with the GRADE approach
    (2017) Izcovich, A.; Criniti, J.; Popoff, F.; Ragusa, M.; Gigler, C.; Malla, C.; Clavijo, M.; Manzotti, M.; Díaz, Marco A.; Neumann Burotto, Gonzalo Ignacio; Catalano, H.; Guyatt, G.
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    Anticoagulation for the initial treatment of venous thromboembolism in patients with cancer
    (2014) Akl, E.; Kahale, L.; Neumann Burotto, Gonzalo Ignacio; Barba, M.; Sperati, F.; Terrenato, I.; Muti, P.; Schuenemann, H.
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    Anticoagulation for the long-term treatment of venous thromboembolism in patients with cancer
    (2014) Akl, E.; Kahale, L.; Barba, M.; Neumann Burotto, Gonzalo Ignacio; Labedi, N.; Terrenato, I.; Sperati, F.; Muti, P.; Schuenemann, H.
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    Assessing the process and outcome of the development of practice guidelines and recommendations : PANELVIEW instrument development
    (2020) Wiercioch, W.; Akl, E. A.; Santesso, N.; Zhang, Y.; Morgan, R. L.; Yepes Nuñez, J. J.; Kowalski, S.; Baldeh, T.; Mustafa, R. A.; Neumann Burotto, Gonzalo Ignacio; Laisaar, K. T.; Raid, U.; Etxeandia Ikobaltzeta, I.; Carrasco Labra, A.; Ventresca, M.; Falavigna, M.; Brignardello Petersen, R.; Morgano, G. P.; Brozek, J.; McConnell, M.; Schunemann, H. J.
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    Authors seldom report the most patient-important outcomes and absolute effect measures in systematic review abstracts
    (2017) Agarwal, A.; Johnston, B. C.; Vernooij, R. W.; Carrasco Labra, A.; Brignardello Petersen, P.; Neumann Burotto, Gonzalo Ignacio; Akl, Ea; Sun, X
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    Bleeding risk in atrial fibrillation patients taking vitamin k antagonists: Systematic review and meta-analysis
    (2013) Lopes, Luciane; Spencer, Frederick A.; Neumann Burotto, Gonzalo Ignacio; Ventresca, M.; Ebrahim, S.; Zhou, Q.; Bhatnaga, N.; Schulman, S.
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    Cómo interpretar guías de práctica clínica elaboradas con metodología GRADE
    (2017) Mendoza, C.; Kraemer, P.; Herrera Salinas, Pablo; Burdiles, P.; Sepúlveda, D.; Núñez, E.; Muñoz, C.; Neumann Burotto, Gonzalo Ignacio
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    Comparison between the standard and a new alternative format of the Summary-of-Findings tables in Cochrane review users : study protocol for a randomized controlled trial
    (2015) Neumann Burotto, Gonzalo Ignacio; Carrasco Labra, Alonso.; Brignardello Petersen, Romina.; Santesso, Nancy.; Mustafa, Reem A.; Mbuagbaw, Lawrence.; Ikobaltzeta, Itziar E.; De Stio, Catherine.; McCullagh, Lauren J.; Alonso Coello, Pablo.; Meerpohl, Joerg J.; Vandvik, Per O.; Brozek, Jan L.; Akl, Elie A.; Bossuyt, Patrick.; Churchill, Rachel.; Glenton, Claire.; Rosenbaum, Sarah.; Tugwell, Peter.; Welch, Vivian.; Guyatt, Gordon.; Schünemann, Holger.
    Abstract Background Systematic reviews represent one of the most important tools for knowledge translation but users often struggle with understanding and interpreting their results. GRADE Summary-of-Findings tables have been developed to display results of systematic reviews in a concise and transparent manner. The current format of the Summary-of-Findings tables for presenting risks and quality of evidence improves understanding and assists users with finding key information from the systematic review. However, it has been suggested that additional methods to present risks and display results in the Summary-of-Findings tables are needed. Methods/Design We will conduct a non-inferiority parallel-armed randomized controlled trial to determine whether an alternative format to present risks and display Summary-of-Findings tables is not inferior compared to the current standard format. We will measure participant understanding, accessibility of the information, satisfaction, and preference for both formats. We will invite systematic review users to participate (that is clinicians, guideline developers, and researchers). The data collection process will be undertaken using the online 'Survey Monkey' system. For the primary outcome understanding, non-inferiority of the alternative format (Table A) to the current standard format (Table C) of Summary-of-Findings tables will be claimed if the upper limit of a 1-sided 95% confidence interval (for the difference of proportion of participants answering correctly a given question) excluded a difference in favor of the current format of more than 10%. Discussion This study represents an effort to provide systematic reviewers with additional options to display review results using Summary-of-Findings tables. In this way, review authors will have a variety of methods to present risks and more flexibility to choose the most appropriate table features to display (that is optional columns, risks expressions, complementary methods to display continuous outcomes, and so on). Trials registration NCT02022631 (21 December 2013)Abstract Background Systematic reviews represent one of the most important tools for knowledge translation but users often struggle with understanding and interpreting their results. GRADE Summary-of-Findings tables have been developed to display results of systematic reviews in a concise and transparent manner. The current format of the Summary-of-Findings tables for presenting risks and quality of evidence improves understanding and assists users with finding key information from the systematic review. However, it has been suggested that additional methods to present risks and display results in the Summary-of-Findings tables are needed. Methods/Design We will conduct a non-inferiority parallel-armed randomized controlled trial to determine whether an alternative format to present risks and display Summary-of-Findings tables is not inferior compared to the current standard format. We will measure participant understanding, accessibility of the information, satisfaction, and preference for both formats. We will invite systematic review users to participate (that is clinicians, guideline developers, and researchers). The data collection process will be undertaken using the online 'Survey Monkey' system. For the primary outcome understanding, non-inferiority of the alternative format (Table A) to the current standard format (Table C) of Summary-of-Findings tables will be claimed if the upper limit of a 1-sided 95% confidence interval (for the difference of proportion of participants answering correctly a given question) excluded a difference in favor of the current format of more than 10%. Discussion This study represents an effort to provide systematic reviewers with additional options to display review results using Summary-of-Findings tables. In this way, review authors will have a variety of methods to present risks and more flexibility to choose the most appropriate table features to display (that is optional columns, risks expressions, complementary methods to display continuous outcomes, and so on). Trials registration NCT02022631 (21 December 2013)
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    Completion and publication rates of randomized controlled trials in surgery an empirical study
    (2015) Rosenthal, Rachel; Kasenda, Benjamin; Dell-Kuster, Salome; Von Elm, Erik; You, John; Neumann Burotto, Gonzalo Ignacio; Tomonaga, Yuki; Saccilotto, Ramon; Amstutz, Alain; Bengough, Theresa; Meerpohl, Joerg J.; Stegert, Mihaela; Tikkinen, Kari A. O.; Blümle, Anette; Carrasco-Labra, Alonso; Faulhaber, Markus; Mulla, Sohail; Mertz, Dominik; Akl, Elie A.; Bassler, Dirk; Busse, Jason W.; Ferreira-González, Ignacio; Lamontagne, Francois; Nordmann, Alain; Gloy, Viktoria; Olu, Kelechi K.; Raatz, Heike; Moja, Lorenzo; Ebrahim, Shanil; Schandelmaier, Stefan; Sun, Xin; Vandvik, Per O.; Johnston, Bradley C.; Walter, Martin A.; Burnand, Bernard; Schwenkglenks, Matthias; Hemkens, Lars G.; Bucher, Heiner C.; Guyatt, Gordon H.; Briel, Matthias
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    Considering intellectual, in addition to financial, conflicts of interest proved important in a clinical practice guideline : a descriptive study
    (2014) Akl, E.A.; El-Hachem, P; Neumann Burotto, Gonzalo Ignacio; Abou-Haidar, H; Schunemann, H; Guyatt, G
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    Decision-Making about Healthcare Related Tests and Diagnostic Strategies: User Testing of GRADE Evidence Tables
    (2015) Mustafa, R.; Wiercioch, W.; Santesso, N.; Cheung, A.; Prediger, B.; Baldeh, T.; Carrasco, A.; Brignardello, R.; Neumann Burotto, Gonzalo Ignacio; Bossuyt, P.; Garg, A.; Lelgemann, M.; Buhler, D.; Brozek, J.; Schunemann, H.