Browsing by Author "Navarrete Dechent, Cristian"

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    Reduction in the number of early melanomas diagnosed during the COVID‐19 pandemic: a single‐centre cohort study
    (2021) Koch Hein, Erica Cristina; Villanueva, Francisco; Marchetti, Michael A.; Abarzúa Araya, Álvaro Rodrigo; Cárdenas de la Torre, Consuelo Paz; Castro, Juan Camilo; Domínguez Covarrubias, Francisco José; Droppelmann, Katherine; Droppelmann, Nicolás; Galindo A., Héctor; León Ramírez, Augusto; Madrid Arenas, Jorge; Molgó Novell, Montserrat; Mondaca, Sebastián; Montero, Pablo H.; Uribe González, Pablo Francisco; Villaseca, Miguel A.; Vinés Vásquez, Eugenio; Navarrete Dechent, Cristian
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    Topical photodynamic therapy with methylaminolevulinate for the treatment of actinic keratosis and reduction of photodamage in organ transplant recipients: A case-series of 16 patients
    (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2012) Hasson, Ariel; Navarrete Dechent, Cristian; Nicklas, Claudia; de la Cruz, Claudia
    Background: Organ transplant recipients (OTR) are at high risk of developing cutaneous neoplasms. Topical photodynamic therapy (PDT) has been used for the treatment of actinic keratosis (AK) in OTR. Aims: The objective was to evaluate the efficacy of PDT with methylaminolevulinate (MAL) in the treatment of facial AK in OTR. As a secondary objective, we wanted to evaluate the usefulness of topical PDT in the reduction of photodamage in OTR. Methods: A prospective, single center, single arm study was made. 16 OTR were included. Topical PDT was applied for 1 or 2 cycles depending on the patient's characteristics. An evaluation of AK was made at visits pre-treatment, at 12 weeks and at 24 weeks. Photodamage was measured with multispectral image technique (SkinCare (R)). Results: A complete response rate of 100% was achieved for AK in all patients; it persisted without change at 12 and 24 weeks of follow-up. 62.5% of patients improved their photodamage as measured by SkinCare (R), but this result was not statistically significant (P = 0.12). All patients had high level of satisfaction at the end of the therapy. Conclusions: MAL-PDT is an effective therapy for the treatment of AK in OTRs. It can reduce photodamage in this group of patients, but these results were not statistically significant.