Browsing by Author "Navarrete, Carlos"

Now showing 1 - 13 of 13
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    Adiponectin levels, cardiometabolic risk factors and markers of subclinical atherosclerosis in children
    (ELSEVIER IRELAND LTD, 2010) Arnaiz, Pilar; Acevedo, Monica; Barja, Salesa; Aglony, Marlene; Guzman, Beatriz; Cassis, Berta; Carvajal, Jacqueline; Moreno, Manuel; Navarrete, Carlos; Berrios, Ximena
    Background: Low levels of adiponectin have been associated with metabolic risk factors (RF) and cardiac disease. Minimal data is available about the relationship between adiponectin and subclinical atherosclerosis. Objectives: To determine the relationship of adiponectin to cardiometabolic RF, C-reactive protein (CRP), anthropometric parameters of obesity, and subclinical atherosclerosis in children.
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    Body fat and its relationship with clustering of cardiovascular risk factors
    (2015) Valentino Peirano, Giovanna Francesca; Bustamante, María José; Orellana, Lorena; Krämer Karmy, Verónica; Durán Agüero, Samuel; Adasme, Marcela; Salazar, Alejandra; Ibarra, Camila; Fernández, Marcelo; Navarrete, Carlos; Acevedo B., Mónica
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    Cardiovascular risk factors among young subjects with high carotid intima media thickness
    (SOC MEDICA SANTIAGO, 2011) Acevedo, Monica; Kraemer, Veronica; Tagle, Rodrigo; Arnaiz, Pilar; Corbalan, Ramon; Berrios, Ximena; Navarrete, Carlos
    Background: Cardiovascular risk factor (RF) assessment is essential to prevent and predict cardiovascular disease. The presence of RF at early ages, are determinant for the presence of atherosclerosis later in life. Aim: To determine the RF profile of young subjects with high carotid intima media thickness (CIMT). Material and Methods: We studied 689 subjects (50% women, mean age 36 6 years) from Santiago, Chile. We determined body mass index (BMI), waist circumference, blood pressure, fasting serum lipids, blood glucose and C-reactive protein. CIMT was assessed by ultrasound using an automatic border recognition software. Results: Body mass index, waist circumference, blood pressure and serum lipids were significantly higher among subjects located in the higher CIMT quartile. Also, subjects in the higher quartile of CIMT had a higher prevalence of three or more RF compared with the lower quartile (p = 0.01). Finally, individuals with three or more RF showed three times more risk of being in the higher CIMT quartile, than subjects with no RF (odds ratio = 3.1, p < 0.01). Conclusions: There is a negative influence of cardiovascular RF on CIMT among young subjects. (Rev Med Chile 2011; 139: 1322-1329).
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    Cardiovascular risk factors in a group of health care workers
    (SOC MEDICA SANTIAGO, 2012) Kramer, Veronica; Adasme, Marcela; Jose Bustamante, M.; Jalil, Jorge; Navarrete, Carlos; Acevedo, Monica
    Background: Health promotion can be carried out at work places. Aim: To assess cardiovascular risk factors among workers of a University hospital. Material and Methods: Cross sectional study of 888 participants (aged 41 +/- 11 years, 76% women), who answered a survey about cardiovascular risk factors. Body mass index, waist, blood pressure and total cholesterol (TC) by capillary method were determined. Results: Self reported prevalence of risk factors were as follows: 19% of participants had high blood pressure, 30% hypercholesterolemia, 6% diabetes, 41% smoked, 88% were sedentary and 26% had a family history of cardiovascular diseases. Five percent of participants did not have any risk factor, 20% had one risk factor, 32% had two and 43% had three or more. The highest frequency of lack of awareness was about blood glucose values. A high blood cholesterol level was found in 27% of those reporting normal cholesterol levels. Likewise, a high body mass index was found in 18% of those reporting a normal weight. Conclusions: The prevalence of cardiovascular risk factors in this group of participants is similar to that found in the last national health survey in Chile. Noteworthy is the lack of awareness about these risk factors. (Rev Med Chile 2012; 140: 602-608).
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    Cholesterol Levels and the Association of Statins With In-Hospital Mortality of Myocardial Infarction Patients Insights From a Chilean Registry of Myocardial Infarction
    (2013) Martínez, Gonzalo; Rigotti Rivera, Attilio; Acevedo B., Mónica; Navarrete, Carlos; Rosales Núñez, Juan Elizabeth; Giugliano, Robert P, Corbalán Herreros, Ramón
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    Comparison of Lipoprotein-Associated Phospholipase A2 and High Sensitive C-Reactive Protein as Determinants of Metabolic Syndrome in Subjects without Coronary Heart Disease: In Search of the Best Predictor
    (HINDAWI LTD, 2015) Acevedo, Monica; Varleta, Paola; Kramer, Veronica; Valentino, Giovanna; Quiroga, Teresa; Prieto, Carolina; Parada, Jacqueline; Adasme, Marcela; Briones, Luisa; Navarrete, Carlos
    High sensitivity C-reactive protein (hsCRP) is a marker of metabolic syndrome (MS) and cardiovascular (CV) disease. Lipoproteinassociated phospholipase A2 (Lp-PLA2) also predicts CV disease. There are no reports comparing these markers as predictors of MS. Methods. Cross-sectional study comparing Lp-PLA2 and hsCRP as predictors of MS in asymptomatic subjects was carried out; 152 subjects without known atherosclerosis participated. Data were collected on demographics, cardiovascular risk factors, anthropometric and biochemical measurements, and hsCRP and Lp-PLA2 activity levels. A logistic regression analysis was performed with each biomarker and receiver operating characteristic (ROC) curves were constructed for MS. Results. Mean age was 46 +/- 11 years, and 38% of the subjects had MS. Mean Lp-PLA2 activity was 185 +/- 48 nmol/mL/min, and mean hsCRP was 2.1 +/- 2.2mg/L. Subjects with MS had significantly higher levels of Lp-PLA2 (P = 0.03) and hsCRP (P < 0.0001) than those without MS. ROC curves showed that both markers predictedMS. Conclusion. Lp-PLA2 and hsCRP are elevated in subjects withMS. Both biomarkers were independent and significant predictors for MS, emphasizing the role of inflammation in MS. Further research is necessary to determine if inflammation predicts a higher risk for CV events in MS subjects.
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    High prevalence of vitamin D deficiency in Chilean healthy postmenopausal women with normal sun exposure: additional evidence for a worldwide concern
    (LIPPINCOTT WILLIAMS & WILKINS, 2007) Gonzalez, Gilberto; Alvarado, Jose N.; Rojas, Auristela; Navarrete, Carlos; Velasquez, Carmen G.; Arteaga, Eugenio
    Objective: To assess the prevalence of vitamin D deficiency in healthy postmenopausal women with normal sun exposure but without vitamin D fortification in their diets.
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    Hipertensión arterial: el factor de riesgo más importante para grosor íntima-media carotídeo elevado y placa carotídea en adultos de Santiago
    (SOC MEDICA SANTIAGO, 2011) Acevedo, Monica; Tagle, Rodrigo; Kramer, Veronica; Arnaiz, Pilar; Marin, Arnaldo; Pino, Felipe; Godoy, Ivan; Berrios, Ximena; Navarrete, Carlos
    Background: Carotid Ultima media thickness (CIMT) is a marker of cardiovascular damage that can be modified by traditional risk factors. Aim: To determine attributable risk factors for a high CIMT among healthy adults. Material and Methods: A sample of 1270 individuals (636 males and 634 females) aged 44 +/- 11 years, was studied. Blood pressure, weight, height, lipid profile and blood glucose were measured in all. CIMT and the presence of atherosclerotic plaques were determined by carotid ultrasound. Standard criteria were used to define hypertension, dyslipidemia and diabetes. Results: Mean CIMT in the sample studied was 0.62 +/- 0.01 mm and percentile 75 was 0.67. The most important risk factor for a CIMT over percentile 75 and the presence of atherosclerotic plaques was hypertension with attributable risks of 54 and 57%, respectively. Conclusions: In this sample, the main risk factor for a high CIMT was hypertension. (Rev Med Chile 2011; 139: 290-297).
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    Impaired Fasting Glucose in Nondiabetic Range : Is It a Marker of Cardiovascular Risk Factor Clustering?
    (2015) Valentino Peirano, Giovanna Francesca; Kramer, Verónica; Orellana, Lorena; Bustamante, María José; Casasbellas, Cinthia; Adasme, Marcela; Salazar, Alejandra; Navarrete, Carlos; Acevedo B., Mónica
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    Patient Adherence to a Cardiovascular Rehabilitation Program : What Factors Are Involved?
    (2015) Bustamante, María José; Valentino Peirano, Giovanna Francesca; Kramer, Verónica; Adasme, Marcela; Guidi Guillón, Dominique Annette; Ibara, Camila; Casasbellas, Cinthia; Orellana, Lorena; Fernández, Marcelo; Navarrete, Carlos; Mónica Acevedo
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    ¿Sirven los marcadores de riesgo no tradicionales en la diferenciación del riesgo cardiovascular en adultos jóvenes con exceso de peso?
    (2013) Krämer Karmy, Verónica; Corbalán Herreros, Ramón; Berríos Carrasola, Ximena; Navarrete, Carlos; Tagle, Rodrigo; Acevedo B., Mónica
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    Some issues in nonparametric Bayesian modelling using species sampling models
    (SAGE PUBLICATIONS LTD, 2008) Navarrete, Carlos; Quintana, Fernando A.; Mueller, Peter
    We review some aspects of nonparametric Bayesian data analysis with discrete random probability measures. We focus on the class of species sampling models (SSMs). We critically investigate the common use of the Dirichlet process (DP) prior as a default SSM choice. We discuss alternative prior specifications from a theoretical, computational and data analysis perspective. We conclude with a recommendation to consider SSM priors beyond the special case of the DP prior, and make specific recommendations on how different choices can be used to reflect prior information and how they impact the desired inference. We show the required changes in the posterior simulation schemes, and argue that the additional generality can be achieved without additional computational effort.
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    Total/HDL cholesterol ratio and non HDL cholesterol as predictors for increased intima media thickness
    (SOC MEDICA SANTIAGO, 2012) Acevedo, Monica; Kraemer, Veronica; Tagle, Rodrigo; Corbalan, Ramon; Arnaiz, Pilar; Berrios, Ximena; Navarrete, Carlos
    Background: LDL, HDL cholesterol and triglycerides, are the most commonly used lipid cardiovascular risk predictor indicators. However population based studies have shown that non-HDL cholesterol and total/HDL cholesterol ratio are better predictors, are easy to measure and do not require fasting. Aim: To determine which lipid indicators are better determinants of subclinical atherosclerosis, measured by intima media thickness (IMT) among subjects without demonstrated atherosclerosis. Material and Methods: Lipid profile, height, weight, blood pressure and bilateral IMT measured by ultrasound with automatic border recognition software, were assessed in 770 men and 854 women aged 45 +/- 11 years, in Santiago de Chile. Results: Mean total cholesterol was 202, HDL 50, LDL 121, triglycerides 157 and non-HDL cholesterol 152 mg/dl. Total/HDL cholesterol ratio was 4.3. Mean IMT was 0.62 mm. All lipid markers were significantly correlated with IMT This correlation was higher for non-HDL cholesterol (r = 0.24, p < 0.0001) and total/HDL cholesterol ratio(r = 0.23, p < 0.0001). In both men and women, total/HDL cholesterol ratio was the best predictor of having an IMT over the 75th percentile (odds ratio 1.21, 95% confidence intervals 1.09-1.35, p < 0.01). Conclusions: Total/HDL cholesterol ratio was the best determinant of subclinical atherosclerosis. (Rev Med Chile 2012; 140: 969-976).