Browsing by Author "Murgas, P."
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- ItemExpression Pattern of Scavenger Receptors and Amyloid-beta Phagocytosis of Astrocytes and Microglia in Culture are Modified by Acidosis: Implications for Alzheimer's Disease(2016) Eugenin, J.; Vecchiola Cárdenas, Andrea Paola; Murgas, P.; Arroyo, P.; Cornejo, F.; Bernhardi Montgomery, Rommy von
- ItemScavenger receptor class A ligands induce secretion of IL1β and exert a modulatory effect on the inflammatory activation of astrocytes in culture(2012) Godoy, B.; Murgas, P.; Tichauer, J.; Von Bernhardi, R.Class-A scavenger receptor (SR-A) is expressed by microglia, and we show here that it is also expressed by astrocytes, where it participates on their inflammatory activation. Astrocytes play a key role on the inflammatory response of the central nervous system, secreting several soluble mediators like cytokines and radical species. Exposure to SR ligands activated MAPKs and NF-kappa B signaling and increased production of IL1 beta and nitric oxide (NO). IL1 beta classically an inflammatory cytokine surprisingly did not increase but inhibited LPS + IFN gamma-induced NO production by astrocytes. Our results suggest that SRs expressed by astrocytes participate in the modulation of inflammatory activation. (C) 2012 Elsevier B.V. All rights reserved.
- ItemSR-A regulates the inflammatory activation of astrocytes(2014) Murgas, P.; Cornejo, F.; Merino Bengoechea, Guillermo Roberto; Bernhardi Montgomery, Rommy von