Browsing by Author "Mosso G. L."
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- ItemClinical features of 17 patients with familial non medullary thyroid carcinomaCarcinoma familiar del tiroides no medular (CFTNM): Características de presentación en 17 casos(2007) Mosso G. L.; Velasco S.; Cardona B.; Fardella C.; González G.; López J.M.; Rodríguez J.A.; Arteaga E.; Salazar I.; Solar A.; González H.; Cruz F.; Mosso G. L.; NCD Risk Factor Collaboration (NCD-RisC)Background: Papillary thyroid carcinoma can have familial aggregation. Aim: To compare retrospectively familial non medullary thyroid carcinoma (FNMTC) with sporadic papillary thyroid carcinoma (PTC). Material and methods: Retrospective analysis of medical records of patients with thyroid carcinoma. An index case was defined as a subject with the diagnosis of differentiated thyroid carcinoma with one or more first degree relatives with the same type of cancer. Seventeen such patients were identified and were compared with 352 subjects with PTC. Results: The most common affected relatives were sisters. Patients with FNMTC were younger than those with PTC. No differences were observed in gender, single or multiple foci, thyroid capsule involvement, surgical border involvement, number of affected lymph nodes and coexistence of follicular hyperplasia. Patients with FNMTC had smaller tumors and had a nine times more common association with lymphocytic thyroiditis. Five patients with FNMTC had local recurrence during 4.8 years of follow up. Conclusions: Patients with FNMTC commonly have an associated chronic thyroiditis, are younger and have smaller tumors than patients with PTC.
- ItemEvidences for mineralocorticoid excess in essential hypertensionExceso de mineralocorticoides en hipertensos esenciales: Enfoque clínico-diagnóstico(2000) Cortés P. P.; Fardella B. C.; Oestreicher C. E.; Gac E. H.; Mosso G. L.; Soto M. J.; Foradori C. A.; Claverie R. X.; Ahuad N. J.; Montero L. J.; Fardella B. C.; NCD Risk Factor Collaboration (NCD-RisC)Background: Primary hyperaldosteronism is more frequent among subjects with essential hypertension than previously thought. The prevalence, according to local and international evidence could fluctuate between 9 and 10%. Aim: To investigate if subjects with essential hypertension have different aldosterone and renin plasma levels than normotensive subjects. Patients and methods: One hundred twenty five subjects with essential hypertension, not receiving medications for at least two weeks prior to the study and 168 age and sex matched normotensive controls were studied. Blood was drawn between 9 and 10 AM during a sodium free diet to determine plasma aldosterone, plasma renin activity and potassium. Results: Plasma aldosterone was higher in hypertensive subjects than controls (11.6 ± 7.6 and 9.9 ± 5.1 ng/dl respectively; p=0.04). Plasma renin activity was lower in hypertensives than controls (1.42 ± 1.28 and 1.88 ± 1.39 ng/ml/h respectively; p<0.001). Thus, plasma aldosterone/plasma renin activity ratio was higher in hypertensives (13.8 ± 13.5 and 8.3 ± 7.8; p<0.001). A pathological ratio was defined as over 25, corresponding to the mean plus two standard deviations of the control group. Primary hyperaldosteronism was found in 5/125 hypertensives (4%) and 1/168 normotensive subject (0.6%). None had hypokalemia. Conclusions: Subjects with essential hypertension have higher plasma aldosterone and lower plasma renin activity than normal controls. A plasma aldosterone/plasma renin activity over 25 was defined as abnormal.
- ItemHyperthyroxinemia and clinical euthyroidism. Report of one caseHipertiroxinemia con eutiroidismo clínico: Análisis a propósito de un caso(1999) López M. J.M.; Mosso G. L.; Campino J. C.; López M. J.M.; NCD Risk Factor Collaboration (NCD-RisC)The association of byperthyroxinemia and enthyroidism is frequent and characterized by high plasma thyroxin concentrations, normal TSH values and absence of clinical signs of hyperthyroidism. We report an asymptomatic 28 years old male presenting with a serum total plasma thyroxin of 18.5 μg/dl (N 6.1-12.5), a free thyroxin of 2.9 ng/dl (N 0.8-1.4), a TSH of 3.4 μIU/ml (N 0.5-5), and a triiodothyronine of 128 ng/dl (N 80-180). Laboratory assessment did not find high thyroxin binding globulin, albumin or prealbumin concentrations or antithyroxin antibodies. The thyroxin binding capacity of albumin was elevated to 58.2 μg/dl (N 11.5-34.1). TSH responded normally to TRH stimulus and was suppressed with exogenous triiodothyronine, which caused an hyperthyroid syndrome. We concluded that this patient had a familial dysalbuminemia.