Browsing by Author "Morgan, Douglas R."

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    14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial
    (ELSEVIER SCIENCE INC, 2011) Greenberg, E. Robert; Anderson, Garnet L.; Morgan, Douglas R.; Torres, Javier; Chey, William D.; Eduardo Bravo, Luis; Dominguez, Ricardo L.; Ferreccio, Catterina; Herrero, Rolando; Lazcano Ponce, Eduardo C.; Mercedes Meza Montenegro, Maria; Pena, Rodolfo; Pena, Edgar M.; Salazar Martinez, Eduardo; Correa, Pelayo; Elena Martinez, Maria; Valdivieso, Manuel; Goodman, Gary E.; Crowley, John J.; Baker, Laurence H.
    Background Evidence from Europe, Asia, and North America suggests that standard three-drug regimens of a proton-pump inhibitor plus amoxicillin and clarithromycin are significantly less effective for eradication of Helicobacter pylori infection than are 5-day concomitant and 10-day sequential four-drug regimens that include a nitroimidazole. These four-drug regimens also entail fewer antibiotic doses than do three-drug regimens and thus could be suitable for eradication programmes in low-resource settings. Few studies in Latin America have been done, where the burden of H pylori-associated diseases is high. We therefore did a randomised trial in Latin America comparing the effectiveness of four-drug regimens given concomitantly or sequentially with that of a standard 14-day regimen of triple therapy.
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    Epidemiology of Helicobacter pylori infection in six Latin American countries (SWOG Trial S0701)
    (2013) Porras, Carolina; Nodora, Jesse; Sexton, Rachael; Ferreccio Readi, Catterina; Jiménez, Silvia; Domínguez, Ricardo L.; Cook Herrera, María Paz; Anderson, Garnet; Morgan, Douglas R.; Baker, Laurence H.; Greenberg, E. Robert; Herrero, Rolando