Browsing by Author "Mora, Italo"
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- ItemDiuretics prevent Rho-kinase activation and expression of profibrotic/oxidative genes in the hypertensive aortic wall(2016) Araos, Patricio; Mondaca, David; Jalil Milad, Jorge; Yañez, Cristián; Novoa, Ulises; Mora, Italo; Ocaranza, María Paz
- ItemMarkedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure(MOSBY-ELSEVIER, 2011) Paz Ocaranza, Maria; Gabrielli, Luigi; Mora, Italo; Garcia, Lorena; McNab, Paul; Godoy, Ivan; Braun, Sandra; Cordova, Samuel; Castro, Pablo; Novoa, Ulises; Chiong, Mario; Lavandero, Sergio; Jalil, Jorge E.Background The small guanosine triphosphatase Rho and its target Rho-kinase have significant roles in experimental remodeling and ventricular dysfunction, but no data are available on Rho-kinase activation in patients with heart failure (HF). We hypothesized that, in patients with chronic HF, Rho-kinase in circulating leukocytes is activated and related to left ventricular (LV) remodeling and dysfunction.