Browsing by Author "Mellado, Rosemarie"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Myocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure
    (SOC MEDICA SANTIAGO, 2010) Luis Winter, Jose; Castro, Pablo; Meneses, Luis; Chalhub, Monica; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Chiong, Mario; Concepcion, Roberto; Mellado, Rosemarie; Hernandez, Claudia; Uribe, Sergio; Lavander, Sergio
    Background: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by cardiomyocytes, associated with decreased deposits of high-energy phosphates (creatine phosphate/ creatine transporter). Magnetic resonance (MR) imaging allows a direct and noninvasive assessment of myocardial metabolites. Aim: To measure myocardial creatine and lipids by MR spectroscopy among patients with HE Material and Methods: Cardiac MR spectroscopy (1.5 Tesla) with Hydrogen antenna and single voxel acquisition was performed in five patients with non-ischemic heart failure, aged 58 +/- 9.7 years, (60% males) and 5 healthy volunteers matched for age and sex. We analyzed the signals of creatine (Cr), lipids (L) and water (W) in the interventricular septum, establishing the water/lipid (W/L) and water/creatine (W/Cr) index to normalize the values obtained. Results: Among patients, left ventricular ejection fraction was 32 +/- 6.9%, 60% were in functional capacity II, 60% had hypertension and one was diabetic. Spectroscopic curves showed a depletion of total Cr, evidenced by the W/Cr index, among patients with heart failure, when compared with healthy controls (1.46 +/- 1.21 and 5.96 +/- 2.25 respectively, p < 0,05). Differences in myocardial lipid content, measured as the W/L index, were not significant (5.06 +/- 2.66 and 1.80 +/- 1.62 respectively, p = 0.08). Conclusions: Among patients with heart failure of non-ischemic etiology, there is a depletion of creatine levels measured by MR spectroscopy. (Rev Med Chile 2010; 138: 1475-1479).
  • Thumbnail Image
    Item
    Xanthine-oxidase inhibitors and statins in chronic heart failure: Effects on vascular and functional parameters
    (ELSEVIER SCIENCE INC, 2011) Greig, Douglas; Alcaino, Hernan; Castro, Pablo F.; Garcia, Lorena; Verdejo, Hugo E.; Navarro, Mario; Lopez, Rafael; Mellado, Rosemarie; Tapia, Fabiola; Gabrielli, Luigi A.; Nogerol, Camilo; Chiong, Mario; Godoy, Ivan; Lavandero, Sergio
    BACKGROUND: Increased oxidative stress in heart failure (HF) leads to inflammation and endothelial dysfunction (ED). Both statins and allopurinol have known anti-oxidant properties, but their utility in HF has not been fully assessed.