Browsing by Author "Martinez, J."

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    Aluminum complexes with new non-symmetric ferrocenyl amidine ligands and their application in CO2 transformation into cyclic carbonates
    (2020) Ríos Yepes, Yersica; Martinez, J.; Sanchez, H. R.; Quintero Ramírez, Celso Noé; Ortega Alfaro, M. C.; Lopez Cortes, J. G.; Daniliuc, C. G.; Antinolo, A.; Ramos, A.; Rojas Guerrero, René
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    Aromatic guanidines as highly active binary catalytic systems for the fixation of CO2 into cyclic carbonates under mild conditions
    (2019) Mesías Salazar, Ángela Diana; Martinez, J.; Rojas Guerrero, René; Carrillo-Hermosilla, F.; Ramos, A.; Fernandez-Galan, R.; Antinolo, A.
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    Chitosan-triclosan particles modulate inflammatory signaling in gingival fibroblasts
    (2018) Pavez, L.; Tobar, N.; Chacon, C.; Arancibia, R.; Martinez, C.; Tapia, C.; Pastor, A.; Gonzalez, M.; Martinez, J.; Smith, P. C.
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    Faint end of the z ∼ 3-7 luminosity function of Lyman-alpha emitters behind lensing clusters observed with MUSE
    (2019) de La Vieuville, G.; Bina, D.; Pello, R.; Mahler, G.; Richard, J.; Drake, A. B.; Herenz, E. C.; Bauer, F. E.; Clement, B.; Lagattuta, D.; Laporte, N.; Martinez, J.; Patricio, V.; Wisotzki, L.; Zabl, J.; Bouwens, R. J.; Contini, T.; Garel, T.; Guiderdoni, B.; Marino, R. A.; Maseda, M. V.; Matthee, J.; Schaye, J.; Soucail, G.
    Contact. This paper presents the results obtained with the Multi-Unit Spectroscopic Explorer (MUSE) at the ESOVery Large Telescope on the faint end of the Lyman-alpha luminosity function (LF) based on deep observations of four lensing clusters. The goal of our project is to set strong constraints on the relative contribution of the Lyman-alpha emitter (LAE) population to cosmic reionization.
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    Gender-related differences in quality of life and depressive symptoms in chilean heart failure patients
    (WILEY, 2019) Diaz, F. Felipe; Verdejo, H.; Vera, O.; Martinez, J.; Ivanovic, P. I.
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    Gingival Wound Healing: An Essential Response Disturbed by Aging?
    (2015) Smith, P. C.; Caceres, M.; Martinez, C.; Oyarzun, A.; Martinez, J.
    Gingival wound healing comprises a series of sequential responses that allow the closure of breaches in the masticatory mucosa. This process is of critical importance to prevent the invasion of microbes or other agents into tissues, avoiding the establishment of a chronic infection. Wound healing may also play an important role during cell and tissue reaction to long-term injury, as it may occur during inflammatory responses and cancer. Recent experimental data have shown that gingival wound healing is severely affected by the aging process. These defects may alter distinct phases of the wound-healing process, including epithelial migration, granulation tissue formation, and tissue remodeling. The cellular and molecular defects that may explain these deficiencies include several biological responses such as an increased inflammatory response, altered integrin signaling, reduced growth factor activity, decreased cell proliferation, diminished angiogenesis, reduced collagen synthesis, augmented collagen remodeling, and deterioration of the proliferative and differentiation potential of stem cells. In this review, we explore the cellular and molecular basis of these defects and their possible clinical implications.
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    Hepatic Resection After Liver Transplantation as a Graft-Saving Procedure
    (2009) Guerra, J. F.; Jarufe, N.; Martinez, J.
    Biliary lesions and hepatic artery thrombosis are known causes of posttransplant liver failure and liver retransplantation. The shortage of organs and the results of retransplantation have forced transplant teams to developed graft-saving techniques. We report two cases who underwent hepatic resection after liver transplantation. In both cases, a left lateral segmentectomy was performed. At follow-up, the patients are well with optimal graft function. We believe this kind of resection represents an adequate alternative in selected cases and must be considered before enlistment for retransplantation.
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    Impact of a simulated laparoscopic training program in a three-year general surgery residency
    (2019) Tejos, R.; Avila, R.; Inzunza, M.; Achurra Tirado, Pablo; Castillo, R.; Romberg, A.; Cordero, O.; Kusanovich Borquez, Rodrigo José; Bellolio R., Felipe; Varas, J.; Martinez, J.
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    Inequalities in mortality due to heart failure in chile: a gender-based analysis
    (WILEY, 2018) Martinez, J.; Diaz, F.; Verdejo, H.; Sanhueza, M.
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    Involvement of MT1-MMP and TIMP-2 in human periodontal disease
    (WILEY, 2010) Oyarzun, A.; Arancibia, R.; Hidalgo, R.; Penafiel, C.; Caceres, M.; Gonzalez, M J; Martinez, J.; Smith, P. C.
    Objectives:
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    Liver transplantation in hemophilia A. Report of one case
    (2019) Benítez, Carlos; Zuniga, P.; Kramer, F.; Valladares, X.; Rojas, P.; Pimentel, E.; Gomez, F.; Cancino, A.; Briceño, Eduardo; Guerra, J.F.; Martinez, J.
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    Modulation of Mammary Stromal Cell Lactate Dynamics by Ambient Glucose and Epithelial Factors
    (2017) Tobar, N; Porras, O.; Smith, Patricio C.; Barros, L.; Martinez, J.
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    Molecular method for the detection of Andes hantavirus infection: validation for clinical diagnostics
    (2016) Vial, C.; Martinez, C.; Rios, S.; Martinez, J.; Vial, P.; Ferrés Garrido, Marcela Viviana; Rivera, J.; Perez, R.; Valdivieso, F.
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    MUSE observations towards the lensing cluster A2744: Intersection between the LBG and LAE populations at z ∼ 3-7
    (2020) de La Vieuville, G.; Pello, R.; Richard, J.; Mahler, G.; Leveque, L.; Bauer, F. E.; Lagattuta, D. J.; Blaizot, J.; Contini, T.; Guaita, L.; Kusakabe, H.; Laporte, N.; Martinez, J.; Maseda, M., V; Schaerer, D.; Schmidt, K. B.; Verhamme, A.
    We present a study of the intersection between the populations of star forming galaxies selected as either Lyman break galaxies (LBGs) or Lyman-alpha emitters (LAEs) in the redshift range 2.9-6.7 and within the same volume of universe sampled by the Multi-Unit Spectroscopic Explorer (MUSE) behind the Hubble Frontier Fields lensing cluster A2744. We define three samples of star-forming galaxies: LBG galaxies with an LAE counterpart (92 galaxies), LBG galaxies without an LAE counterpart (408 galaxies), and LAE galaxies without an LBG counterpart (46 galaxies). All these galaxies are intrinsically faint because of the lensing nature of the sample (M-1500 >=-20.5). The fraction of LAEs among all selected star-forming galaxies increases with redshift up to z similar to 6 and decreases for higher redshifts, in agreement with previous findings. The evolution of LAE/LBG populations with UV magnitude and Ly alpha luminosity shows that the LAE selection is able to identify intrinsically UV faint galaxies with M-1500 >=-15 that are typically missed in the deepest lensing photometric surveys. The LBG population seems to fairly represent the total population of star-forming galaxies down to M-1500 similar to-15. Galaxies with M-1500<-17 tend to have SFRLy alpha-17, including galaxies only detected by their Ly alpha emission, with a large scatter. These trends, previously observed in other samples of star-forming galaxies at high-z, are seen here for very faint M-1500 similar to-15 galaxies; that is, much fainter than in previous studies. The present results show no clear evidence for an intrinsic difference between the properties of the two populations selected as LBG and/or LAE. The observed trends could be explained by a combination of several phenomena, like the existence of different star-formation regimes, the dust content, the relative distribution and morphology of dust and stars, or the stellar populations.
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    NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration
    (2010) Tobar, N.; Guerrero, J.; Smith, P. C.; Martinez, J.
    BACKGROUND: The influence of the stromal microenvironment on the progression of epithelial cancers has been demonstrated. Unravelling the mechanisms by which stromal cells affect epithelial behaviour will contribute in understanding cellular malignancy. It has been proposed that redox environment has a role in the acquisition of malignancy. In this work, we studied the influence of epithelial cells on the stromal redox status and the consequence of this phenomenon on MCF-7 cell motility.
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    Overexpression of Lin28a delays Xenopus metamorphosis and down-regulates albumin independently of its translational regulation domain
    (2019) Gundermann, D.G.; Martinez, J.; De Kervor, G.; González Pinto, Karina; Larraín Correa, Juan Agustín; Faunes Quinteros, Fernando Emerson
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    Simvastatin alters fibroblastic cell responses involved in tissue repair
    (WILEY-BLACKWELL, 2011) Caceres, M.; Romero, A.; Copaja, M.; Diaz Araya, G.; Martinez, J.; Smith, P. C.
    Background and Objective: Statins have been used to control hypercholesterolemia. However, these drugs also exert pleiotropic effects that include the modulation of inflammation and cell signaling. The present study has analyzed the effects of simvastatin on several cell responses involved in tissue repair, including cell adhesion, cell migration and invasion, actin cytoskeleton remodeling and cell viability.
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    Theoretical study of adsorption of Sarin and Soman on tetrahedral edge clay mineral fragments
    (2006) Michalkova, A.; Martinez, J.; Zhikol, O. A.; Gorb, L.; Shishkin, O. V.; Leszczynska, D.; Leszczynski, J.
    This study provides details of the structure and interactions of Sarin and Soman with edge tetrahedral fragments of clay minerals. The adsorption mechanism of Sarin and Soman on these mineral fragments containing the Si4+ and Al3+ central cations was investigated. The calculations were performed using the B3LYP and MP2 levels of theory in conjunction with the 6-31G(d) basis set. The studied systems were fully optimized. Optimized geometries, adsorption energies, and Gibbs free energies of Sarin and Soman adsorption complexes were computed. The number and strength of formed intermolecular interactions have been analyzed using the AIM theory. The charge of the systems and a termination of the mineral fragment are the main contributing factors on the formation of intermolecular interactions in the studied systems. In the neutral complexes, Sarin and Soman is physisorbed on these mineral fragments due to the formation of C-(HO)-O-..., and O- (HO)-O-... hydrogen bonds. The chemical bond is formed between a phosphorus atom of Sarin and Soman and an oxygen atom of the -2 charged clusters containing an Al3+ central cation and -1 charged complex containing a Si4+ central cation (chemisorption). Sarin and Soman interact mostly in the same way with the same terminated edge mineral fragments containing different central cations. However, the interaction energies of the complexes with an Al3+ central cation are larger than these values for the Si4+ complexes. The interaction enthalpies of all studied systems corrected for the basis set superposition error were found to be negative. However, on the basis of the Gibbs free energy values, only strongly interacting complexes containing a charged edge mineral fragment with an Al3+ central cation are stable at room temperature. We can conclude that Sarin and Soman will be adsorbed preferably on this type of edge mineral surfaces. Moreover, on the basis of the character of these edge surfaces, a tetrahedral edge mineral fragment can provide effective centers for the dissociation.
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    Trasplante hepático por insuficiencia cardíaca secundaria a telangiectasia hemorrágica hereditaria o enfermedad de Rendu Osler Weber. Caso clínico
    (2017) Ahumada, V.; Tejos, R.; Moraga, F.; Achurra Tirado, Pablo; Godoy, I.; Loyola, S.; Torres Montes, Paula Javiera; Kolbach Rengifo, Marianne Helene; Benitez, Carlos; Guerra, J.; Jarufe Cassis, Nicolás; Martinez, J.
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    Triclosan inhibits tumor necrosis factor-alpha-stimulated urokinase production in human gingival fibroblasts
    (WILEY, 2009) Arancibia, R.; Caceres, M.; Martinez, J.; Smith, P. C.
    Background and Objectives: Destruction of the supporting periodontal tissues is mediated by the action of several proteolytic enzymes. Urokinase is a serine protease that plays a key role in connective tissue destruction through conversion of plasminogen into plasmin. The present study was conducted to evaluate the effect of triclosan on the production and activity of urokinase in cultured gingival fibroblasts.